Sentences with phrase «dna hypermethylation»

Daxx represses RelB target promoters via DNA methyltransferase recruitment and DNA hypermethylation.

Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»

DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

Not exact matches

By contrast, in more than 90 % of endometrial cancers, the gene has undergone hypermethylation, an epigenetic modification that doesn't change its DNA sequence but renders it inactive.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

The inhibition of DNMT, especially DNMT1, would block the hypermethylation of the newly synthesized DNA strand, resulting in the reversal of the hypermethylation and the re-expression of the silenced genes (11, 12, 13).

Biologically, hypermethylation often silences genes that keep runaway cell growth in check, and its appearance in the DNA code of breast cancer - related genes shed into the blood may indicate that a patient's cancer growth is increasing and the disease has worsened.

The scientists then used statistical models to evaluate the distribution of cancer - linked DNA in the patients» blood samples over the seven - year study to find the largest degree of differences between patients with low and high levels of evidence of hypermethylation in their DNA.

The new study found significant hypermethylation in the most aggressive meningiomas, and showed that these DNA modifications specifically silenced genes that usually inhibit FOXM1 expression and Wnt signaling.

Previous research has identified excessive methylation of DNA, or «hypermethylation,» as a ubiquitous aspect of cancer development.

He noted that there are some ongoing studies that may further inform this difference in the future, including tumor DNA analysis with whole exome sequencing and tumor RNA analysis with RNAseq, evaluation of circulating cell - free tumor DNA, and hypermethylation.

In mouse embryo fibroblasts (MEFs)[2], as well as in the PCa cell lines [unpublished data], DAXX represses expression of these genes via mechanisms that include its binding to DNA methyl transferases (DNMTases) and hypermethylation of the promoter regions of the corresponding genes [2].