We found that if we transplanted that naked DNA into another bacterial species, along with associated restriction enzymes [molecular scissors that cut
DNA in specific places], the cell's original DNA would be destroyed.
Not exact matches
A short, guide RNA leads the
DNA - cutting enzyme Cas9 to
specific places in the genetic instructions that scientists want to slice.
Then,
in a separate step, a genetic construct known as single - guide RNA, which steers Cas9 to the
specific spots
in DNA where cuts are desired, is also
placed into the cells.
The DNase I data exploits a structural feature of regulatory
DNA that's been known for decades: the binding of sequence -
specific transcriptional regulators
in place of nucleosomes creates DNase I hypersensitive sites, or DHSs.