Sentences with phrase «dna repair»

Publication in Human Molecular Genetics on a new link between Huntington's disease and DNA repair

Visit the Frontiers of Photobiology: Nobel Lecture by Aziz Sancar (The Nobel Prize in Chemistry 2015 «for mechanistic studies of DNA repair») Nobel Lecture by Roger Y. Tsien (The Nobel Prize in Chemistry 2008 «for the discovery and development of the green fluorescent protein, GFP») Interviews with Johann Deisenhofer, Robert Huber, Hartmut Michel (The Nobel Prize in Chemistry 1988 «for the determination of the three - dimensional structure of a photosynthetic reaction centre»)

However, over 50 % of GBM tumors generate a DNA repair protein called MGMT (methylguanine methyltransferase) that effectively neutralizes temozolomide chemotherapy.

After creating a stem cell model of the disease from patients» skin cells, the Scripps Research scientists found strong evidence for the involvement of a DNA repair enzyme in the FXN triplet repeat expansion.

Unfortunately, he adds, developing a drug that stops MSH2 isn't an option, because people could become even less healthy if they lose some of their DNA repair capability.

Two CMBN groups have identified a DNA repair gene that modify somatic and germline CAG trinucleotide repeat instability in the Huntingtin gene.

A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.

Researchers at Karolinska InstitutetKarolinska Institutet / ScilLifeLab and the University of Hong Kong has found a molecular mechanism for DNA repair where the protein PARP - 1 in an unexpected way interacts with sleep regulating proteins in humans.

How are microbial communities assembled in the > 5,000 - y - old subsurface of marine sediment, and do they undergo adaptive evolution or accumulate mutations due to impaired DNA repair under such energy - limited conditions?

We have invited frontline female scientists in molecular biology, DNA repair and neuroscience to lecture on their research and share their experience.

Remarkably, some prokaryotes employ a structurally distinct family of nucleases with a dual function e.g., in DNA repair and antiviral immunity.

This unbuckling of the smaller protein, ubiquitin, is saddled with a jawbreaker term called deubiquitylation, but Smerdon and Mao say it makes DNA repair more efficient and that without it repair would be next to impossible.

BRCA1 is a key protein involved in DNA repair, and mutations that impair its function increase the risk for breast and ovarian cancer.

To a large degree this is based on the observation that any breakdown of the extremely efficient DNA repair mechanisms present in our cells produces a range of conditions, many of which appear superficially similar to aging.

Human genetic diseases with DNA repair defects such as Huchinson - Gilford Progeria all show premature aging.

Activation of ERK1 / 2 triggers G2 checkpoint which is considered protective from radiation - induced cell death [8, 9], while activated AKT is known to promote DNA repair and inhibition of apoptosis induction [10].

Several genetic variations were discovered in genes that are suspected to play a role in drug resistance, notably those that code transporter proteins and those implicated in DNA repair.

Reduction of the DNA repair factor led to an accumulation of DNA damage and to neuronal shrinkage.

Neurogenetics of ageing: impact of DNA repair and macrophage function in Alzheimer disease Meryl Sønderby Lillenes

Our team is particularly interested in understanding how DNA repair functions in vivo, in neurons and muscles, and how the transcriptional function is properly restored.

Doesn't mitochondrial DNA repair require a vector that can transfect every cell in the body?

Other DNA repair deficits can cause a range of diseases such as leukemia, breast cancer and hereditary non-polyposis colorectal cancer, a common cause of colon cancer in Western nations.

Despite the efficiency of DNA repair mechanisms, some DNA damage is left unrepaired leading to the gradual accumulation of DNA lesions in cells.

Biswas AK, Mitchell DL, Johnson DG (2014) E2F1 responds to ultraviolet radiation by directly stimulating DNA repair and suppressing carcinogenesis.

Complementing a canonical route for DNA repair, the new mechanism, published in Proceedings of the National Academy of Sciences in 2009, expanded the ways in which cells cope with damaged DNA.

Indeed, mice defective in DNA repair exhibit features of premature aging.

Nevertheless, any direct evidence linking DNA damage to chronic inflammation stems from recent findings in progeroid (accelerated aging) syndromes and accompanying mouse models that carry inborn DNA repair defects.

Similar to bacteria, mammals provide ample evidence that mechanisms of DNA repair and immunity have evolved together.

DNA repair, in general, is a necessary process that allows our cells to correct mistakes, or mutations, that arise within our genetic code.

The latter triggers a vicious cycle of persistent DDR and pro-inflammatory signals leading to chronic inflammation, tissue malfunction and degeneration with old age; in DNA repair - deficient patients, the rapid accumulation of DNA damage (in view of the DNA repair defect) would trigger the untimely activation of DDR signaling leading to the early manifestation of age - related pathology that is associated with chronic inflammation.

Mutation rates ten-fold higher than typical lung cancers in humans, though within three-fold of «hypermutator» tumors with mutations in DNA repair genes.

This is called transcription - coupled repair, or TCR, an aspect of one of four known DNA repair systems.

The synthesized passenger pigeon DNA from Phase 1.3 will be integrated into the genome by the cell's own DNA repair mechanism — homologous recombination.

As evidenced in human diseases, defects in DNA repair induce senescence and degeneration of nervous and endocrine / exocrine tissues.

Research Paper Role of TRF2 in efficient DNA repair, spheroid formation and Cancer Stem Cell maintenance Arka Saha, SwatiShree Padhi, Madhabananda Kar, Shomereeta Roy, Prasanta Maiti, Birendranath Banerjee Oncomedicine 2017; 2: 71 - 79.

Schrock MS, Batar B, Lee J, Druck T, Ferguson B, Cho JH, Akakpo K, Hagrass H, Heerema NA, Xia F, Parvin JD, Aldaz CM, Huebner K. (2017) Wwox - Brca1 interaction: role in DNA repair pathway choice.

An obvious question is how cellular senescence caused by deficient DNA repair finally affects the aging of a living organism.

The researchers then concluded that as the amount of NAD + in cells declines with age, there aren't enough of these molecules to prevent harmful interactions between proteins called DBC1 (which is found across a wide range of organisms, from bacteria to humans) and PARP1 (a protein that is known to control DNA repair).

Salk researchers show how DNA repair proteins distinguish DNA breaks at cellular and viral genomes to activate an appropriately scaled response.

T - antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS - 1 and Rad51.

The Deaconescu Laboratory focuses on structural studies by X-ray crystallography, small - angle X-ray scattering and electron microscopy of protein - protein and protein - nucleic acid complexes, particularly those involved in DNA repair and transcriptional regulation.

This protein was previously thought to be located in the cell nucleus and to be involved in DNA repair.

The research and collaboration activities are organized around the central concepts that cancer results from the accumulation of genomic alterations, and that well - defined descriptions of DNA repair mechanisms, cancer genomes, and gene expression landscapes can reveal the vulnerability of cancer to interventions.

GAPDH participates in nuclear events including transcription, binding RNA, RNA transportation, DNA replication, DNA repair and apoptosis.

Her research is shedding light on anti-cancer genes, DNA repair mechanisms that promote longevity, molecular pathways that protect cells against stress, and stem cells and their role in aging and age - related disease.

Presence of a biologically significant amount of SP cells in the parental population is indicative of the presence of cells with efficient DNA repair capacity.

Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae.

Estrogen receptor β - mediated nuclear interaction between IRS - 1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma.

Poly (ADP - ribose)- binding zinc finger motifs in DNA repair / checkpoint proteins.

We report a role of TRF2 in cancer stem cell maintenance and efficient DNA repair in the clonospheric sub-population of HCT 116 cell line.