Sentences with phrase «dna sequencing studies»

700 billion DNA sequences The study was published in the scientific journal Nature Communications.

Not exact matches

They also don't share the same DNA because studies have found that identical twins can have different DNA sequences.

June 19, 2013 — A Cornell University study offers further proof that the divergence of humans from chimpanzees some 4 million to 6 million years ago was profoundly influenced by mutations to DNA sequences that play roles in turning genes on and off.

Vestigial features, study of ebryonic development, biogeography, DNA sequencing, examining pseudogenes, study of endogenous retroviruses, labratory direct examination of natural selection in action in E-Coli bacteria, lactose intolerance in humans, the peppered moth's colour change in reaction to industrial pollution, radiotrophic fungi at Chernobyl all add to the modern evolutionary synthesis.

Tangible proof can be found by studying vestigial features, ebryonic development, biogeography, DNA sequencing, pseudogenes, endogenous retroviruses, labratory direct examination of natural selection in action in E-Coli bacteria, lactose intolerance in humans, the peppered moth's colour change in reaction to industrial pollution, radiotrophic fungi at Chernobyl... all of these things add to the modern evolutionary synthesis.

In their ACS Central Science study, Disney and his colleagues used DNA sequencing to evaluate thousands of small molecules as potential drug candidates.

Overall, a study of the genome sequences of 57 colorectal cancers showed, on average, 4.42-fold more somatic nuclear mitochondrial DNA as compared to matched healthy blood controls.

«From purely looking at the DNA sequences we can conclude that snakes retain many enhancers that, based on mammalian studies, we thought were limb enhancers,» says senior study author Douglas Menke, a geneticist at the University of Georgia.

Willerslev's team, in a separate 2015 study, was able to sequence Kennewick Man's DNA and confirm he was, in fact, related to all Native Americans.

They aimed to extract ancient DNA from organisms trapped in amber to sequence extinct genes, recover dormant life forms and study protein evolution.

In a study published last June in the Journal of Human Genetics, researchers sequenced the mitochondrial DNA of 12 Yamnaya individuals, along with their immediate predecessors and descendants.

In 2015 a series of studies sequenced the DNA of human bones and other remains from many parts of Europe and Asia.

It studies altered gene functions that are not due to a change in the DNA sequence, but may nevertheless be inherited.

«There's been a huge focus on studying ancient DNA from the sequence point of view.

Weiner, Elliott and colleagues studied the DNA sequences for two human monoclonal antibodies — one able to broadly target influenza A viruses and one able to broadly target influenza B viruses — with collaborators at Inovio and MedImmune.

They specifically studied the length of telomeres (repeated DNA sequences) on the ends of chromosomes in leukocytes (white blood cells); the protective caps are believed to be markers of biological aging, because they shrink over time.

We carried out detailed genetic studies and used whole genome sequencing to look at every part of the DNA at diagnosis, and every part of the DNA at relapse,» says Dr. Dick.

The new study, led by Johannes Krause, a geneticist at the Max Planck Institute for the Science of Human History in Jena, Germany, used next - generation sequencing methods to read stretches of any DNA present in a sample and fish out those that resembled human DNA.

He participated in a 2010 study that identified DNA sequences from 16 ancient Egyptian royal mummies, including Tutankhamun.

The sequencing success, reported this week in Nature Communications, «finally proves to everyone that there's DNA preserved in ancient Egyptian mummies,» says Albert Zink, a biological anthropologist at the Institute for Mummy Studies in Bolzano, Italy.

Now Robert Belshaw at Plymouth University, UK, and Gkikas Magiorkinis at the University of Oxford, who study whether these viral DNA sequences contribute to disease, have found evidence that we do share some of these sections of DNA with our extinct cousins.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

As an undergraduate studying genome sciences at the National Autonomous University of Mexico, she was immediately fascinated when she read some of the early papers about sequencing Neandertal mitochondrial DNA.

In this study, rather than studying one iPS cell line, the researchers derived and sequenced 10 iPS cell clones from each patient tissue sample to get a better understanding of mitochondrial DNA mutation rates.

«The DNA sequence is the same in a brain cell, a liver cell and a heart cell,» said Jingyi «Jessica» Li, the study's corresponding author and a UCLA assistant professor of statistics.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

She hopes that collecting DNA from the clumped crystals will lead to more reliable sequences, especially from human bones, which «could dramatically improve archaeological and anthropological studies, as well as forensic case studies».

The researchers estimate that in their study, each sample cost US$ 35, excluding labor, to test, but the cost will fall as DNA sequencing technology becomes cheaper.

In this study that used deep DNA sequencing of bacterial specific genes, the guts of both males and females exposed to lead had all of the similar complexity in microbiota as those not exposed.

The new study's lead author, Barbara Wallner, an evolutionary biologist at the University of Veterinary Medicine in Vienna, paired these old, yet meticulously kept data with modern DNA sequencing techniques to investigate the origins of today's horse breeds.

With the state - of - the - art DNA sequencing technology used in this study, they will be able to pinpoint the exact mistake in each patient's SS - related genes.

Large - scale methods of probing samples, such as DNA sequencing, microarrays, and automated gene - function studies, are filling new databases to the brim.

By only analysing DNA sequences that bind to cohesin, roughly one per cent of the genome, it would allow us to analyse an individual's mutations and make it much easier to conduct studies to identify novel harmful mutations,» Martin Enge concludes.

«It was a big challenge to extract the DNA sequences from the fossil mammoths and mastodons and then to line these up with DNA from the modern elephants,» says Nadin Rohland, an evolutionary geneticist at Harvard Medical School in Boston and the study's lead author.

With modern advances in DNA sequencing technology, detecting the presence of forest mammals based on DNA detection in the guts of invertebrates has become a potential approach to study the diversity of forest mammals.

In the current study, Huc and his colleagues have focused on enzymes that are generically capable of binding to DNA, irrespective of its base sequence.

The old DNA that sticks to the bait is then studied through genetic sequencing.

In their studies on phylogenetics and biogeography, Besnard and his colleagues have also sequenced DNA from preserved plants in herbaria.

The unmapped DNA also sometimes resembles known, mapped genes, which can interfere in attempts to study similar sequences.

The DNA analysis used in this study focused on mitochondrial DNA, which is easier to recover from fossils than the DNA in chromosomes, because each cell has thousands of copies of the relatively short mitochondrial DNA sequence.

The study adds to evidence that gene editing may need to be adapted to each patient's genome, to ensure there aren't variants in DNA sequence in or near the gene being targeted that would throw off the technology.

«DNA sequencing is a powerful tool, but it is still quite expensive and has several technological and functional limitations that make it difficult to map large areas of the genome efficiently and accurately,» says Jason Reed, Ph.D., principal investigator on the study.

«We're left studying the DNA sequence of modern organisms and trying to piece it together.»

The research team from the National Human Genome Research Institute (NHGRI) and the National Cancer Institute (NCI), both parts of NIH, extended their recent genome sequencing study of skin bacteria, using DNA sequencing techniques optimized for identifying fungi.

Described in a study published in the journal Nature Communications, this novel approach uses high - speed atomic force microscopy (AFM) combined with a CRISPR - based chemical barcoding technique to map DNA nearly as accurately as DNA sequencing while processing large sections of the genome at a much faster rate.

In the first study of human fungal skin diversity, National Institutes of Health researchers sequenced the DNA of fungi at skin sites of healthy adults to define the normal populations across the skin and to provide a framework for investigating fungal skin conditions.

«Humans vary in their DNA sequences, and what is taken as the «normal» DNA sequence for reference can not account for all these differences,» says Stuart Orkin, MD, of Dana - Farber Boston Children's Cancer and Blood Disorders Center and co-corresponding author on the study with Matthew Canver, an MD - PhD student at Harvard Medical School.

Peter Forster, a geneticist at the University of Cambridge, says mistakes happen a lot — between 60 percent and 70 percent of published studies of sequences of human mitochondrial DNA contain significant errors.

Their to - do list includes determining whether the fossils might contain proteins or DNA suitable for sequencing, reconstructing the environment the hominins lived in, and studying differences between males and females.

The study was performed using single stem cells cultivated to provide sufficient DNA for whole genome sequencing.