Not exact matches
To understand the selection mechanism behind mutations, network - based studies were used to estimate the importance of a mutated protein compared to non-mutated ones in signalling and protein — protein interaction networks.10, 11,12,13 Proteins mutated in cancer were found
having a high number of interacting partners (i.e., a high degree of
connectivity), which indicates high
local importance.10 Mutated proteins are also often found in the centre of the network, in key global positions, as quantified by the number of shortest paths passing through them if all proteins are connected with each other (i.e., they
have high betweenness centrality; hereafter called betweenness).11, 12 Mutated proteins also
have high clustering coefficients, which means their neighbours are also neighbours of each other.10, 13 Moreover, neighbourhood analysis of mutated proteins
have been previously successfully used to predict novel cancer - related genes.14, 15 However, to the best of our knowledge, no study
has concentrated particularly on the topological importance of first neighbours of mutated proteins in cancer, and their usefulness as drug targets themselves.
The London Grid for Learning (LGfL), a community of 2,500 schools, academies and
local authorities which benefit from the bulk buying of Internet
connectivity in London Boroughs,
has launched TRUSTnet — a nationwide service which enables substantial savings plus a range of essential resources
Eight in ten schools (82 %) rely on district technicians for issues related to devices — this may not be surprising, given that districts often provide devices and
connectivity; only one in three schools
has onsite staff to support
local network configuration, which is especially problematic given that 27 percent of schools will need significant high - density wireless network upgrades in the next three years (Figure 2).
In terms of
connectivity it
has a dual SIM tray, so you when you are traveling you can through in a
local SIM to save on data.
What the SamTab also
has, and what lifts the PlayBook above the iPad, is DLNA
connectivity which is going to be lots of fun for people turning up at a new place and being able to beam their content straight over a
local network and onto a TV.
I wish
connectivity wouldn't be relegated to
local: (I don't
have any friends to sit on a couch: (or a couch... or friends: -LRB--LRB-(life's hard after an accident * cue violins *
E3 2004
would see a
local multiplayer mode in Hunters revealed, but further experimentation with characters and online
connectivity eventually saw it shift to become the more multiplayer - orientated game that we now know.
Video doorbell features such as recording video only on a
local NAS, or keeping
connectivity only within your own home network,
would be valuable extra data points in making a purchasing decision.
He mentioned that it
would enable you to use Alexa for
local functions even if the internet
connectivity was down.
On the home appliance side, Samsung
has a substantial number of devices for sale that feature smart home functionality and also
has its own SmartThings standard for networked
local connectivity among products.