Sentences with phrase «dt40 cells expressing»

Multi-nucleus cells expressing genes needed to form skeletal muscle can be seen in flower - like clumps forming as cells fuse together.

The trimer - expressing cells even died more quickly than cells expressing mutant forms of SOD1 that are found in severe hereditary ALS cases.

They found — as they did in the 2016 study — that when these cells expressed SOD1 mutants that predominantly form trimers, the cells died much more quickly than control cells containing normal SOD1.

Yu said the impairment of sensory nerve regeneration in diabetic corneas is due to decreased ciliary neurotrophic factor, as evidenced by the fact that dendritic cells express ciliary neurotrophic factor (CNTF) in normal and healing corneas but decrease in diabetic corneas due to the reduced infiltration of dendritic cells.

Using polymerase chain reaction methods that amplify DNA and Jones» assay that detects by - products of ALDH, the Johns Hopkins team found that regulatory T - cells express high levels of ALDH.

Here they have been infected by a herpes virus that carries a «brainbow cassette,» which makes cells express proteins that are tagged with a variety of fluorescent colors.

Many cells expressing the HIV - 1 Gag protein were detected at the surface of the nasopharyngeal tonsil or adenoid.

Here, cells expressing the interacting domains of v - and t - SNAREs on the cell surface were found to fuse spontaneously, demonstrating that SNAREs are sufficient to fuse biological membranes.

The researchers found that aggressive LUAD cells expressed a number of proteins that allow them to persist outside the lungs in small numbers.

Each cell expresses a different color, allowing researchers to trace connections in the fish's neural network.

«Taken together, these results support the hypothesis that multiple myeloma cells express bone - related genes in a Runx2 - dependent fashion that mimics bone marrow resident cells and likely contributes to tumor survival and growth in the bone microenvironment,» Yang and colleagues wrote in the paper.

The team found that brown fat cells express the ERRγ gene all the time (not just in response to cold) and that white fat cells do not express the gene at all.

Actively regenerating tissues expressing a gene have mRNAs with shorter tails, while mature cells expressing that same gene have mRNAs with longer tails,» says Vairavan Lakshmanan, who is one of the lead authors of the paper that details these findings.

Proliferating Cells Express mRNAs with Shortened 3» Untranslated Regions and Fewer MicroRNA Target Sites

In a mouse model of triple - negative breast cancer, mice injected with cancer cells that over-express ZMYND11 had tumor volumes of less than 50 cubic millimeters while control mice and those injected with cells expressing ZMYND11 deficient for binding to the methyl group had tumor volumes ranging from 150 to 400 cubic millimeters at eight weeks.

Living cells express genes involved in physiological functions like development and metabolism via complex mechanisms.

A team of researchers led by Rodrigo Lacruz, MSc, PhD, assistant professor in the Department of Basic Science and Craniofacial Biology at NYU College of Dentistry, has published a paper in Scientific Reports (5:15803) titled «Dental enamel cells express functional SOCE channels,» which reports the results of a study showing for the first time the mechanism of calcium transport essential in the formation of dental enamel.

Cervical cancer cells expressing a wound - healing signal (green) in response to TRAIL stimulation.

In healthy breast tissue, the percentage of cells expressing molecular marker Ki67 (green) and p27 (red) was low.

When the researchers examined cells expressing either Ebola or Marburg VP40 and then added in BAG3, they found that VLP budding went down in a dose - dependent manner.

The neurons express a pan neuronal marker Map2 in green and a percentage of the cells express a marker for inhibitory neurons, GABA, in red.

The enzyme has the novel ability to convert a chemical, metronidazole, into a toxin, which allows researchers to selectively kill the cells expressing it.

«The genes that a taste cell expresses define essentially every aspect of that cell's behavior, from how it will respond to taste stimuli to how it will communicate with other cells,» said study co-leader Brian Lewandowski, PhD, a Monell physiologist.

The researchers then compared tumor cells isolated from multiple different breast cancer patients and found that cells expressing lower amounts of Numb - 1 and -2 were more resistant to the chemotherapy agent cisplatin.

Tumor cells expressing p53 (left) have fewer focal adhesions (red) and lower levels of active p130Cas (green)-- rendering them noninvasive — compared with p53 - deficient tumor cells (right).

One difference that is clear is that exhausted T cells express the programmed cell death protein - 1 (PD - 1), which commands them not to attack normal, healthy cells, but can also prevent them from striking at cancerous or chronically infected cells.

As a result, it was possible to use in situ hybridization to trace the cells expressing ELH to their site of origin.

The new study revealed that pancreatic cancer cells not only send signals that make macrophages produce abnormal amounts of dectin - 1 surface receptors, but also that make tumor cells themselves express high levels of galectin - 9.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

The treatment is based on making bone marrow cells express the telomerase enzyme, which is responsible for repairing telomeres.

Like OSNs, animal cells expressing ORs responded to the odorant of interest, emitting fluorescence.

And IL - 22 helped tumor cells express stem - cell genes through epigenetic changes to these genes.

To explore this idea, they induced heart attacks in mice and then studied the fibroblasts to see if the cells expressed markers characteristic of endothelial cells.

When shRNAs deactivating PIM1 were introduced to cells expressing MYC, those cells died, demonstrating a synthetic lethal relationship between MYC and PIM1.

In one experiment, the researchers created arrays of mammary epithelial cells and asked how adding one or more cells expressing low levels of the cancer gene RasG12V affected the cells around them.

Gene expression analysis suggests that club cells express high amounts of antiviral genes in response to infection.

They found that normal cells grow faster when in an organoid with cells expressing RasG12V at low levels, but required more than one mutant cell to kick - start this abnormal growth.

The team has identified that aggressively spreading cancer cells express a protein called Myosin - 10 which drives cancer cell motility.

Two types of vaccines were used for the study: one constructed with genetically engineered DNA molecules that teach immune system cells to recognize premalignant cells expressing HPV16 E7 proteins, and one that is a non-infectious, engineered virus that targets and kills precancerous cells marked by HPV16 and HPV18 E6 and E7 proteins.

AFRICAN GREEN MONKEY CELL: An African green monkey kidney cell expressing the gene c - src, imaged using Bessel beam plane illumination.

CAR - Ts also have their limitations; they target specific proteins, but not all cancer cells express these and some healthy ones may.

Dsg3 CAAR - T cells exhibit specific cytotoxicity against cells expressing anti-Dsg3 BCRs in vitro and expand, persist, and specifically eliminate Dsg3 - specific B cells in vivo.

In experiments on yeast cells expressing the mouse P - gp protein, 16 of the chemicals stopped it from working (Science Advances, doi.org/bd9b).

In the new study, Chen and colleagues tried to figure out if cells expressing GRPR were the long - sought itch - only neurons.

Neil Johnson's lab at the Fox Chase Cancer Center examined treatment resistance in breast cancer cells expressing the same BRCA1185delAG mutation and determined that the RING - deficient BRCA1 protein was also responsible for loss of sensitivity to certain types of cancer treatments.

However, examining OS tumours the research team behind the new results found that OS cancer cells express special enzymes and receptors, enabling them to degrade bone tissue themselves.

«Once their immune system found the correct receptor, T - cells expressing those receptors multiplied, leading to an overall reduction in the structural diversity of their T - cell receptors.»

In the new study, the researchers discovered that during the second trimester of human brain development, oRG cells express genes related to a fundamental signaling pathway called mTOR, defects in which have previously been implicated in autism and several other psychiatric disorders.

According to the researcher Rosalva Rangel Corona, head of the project, the antitumor effect of interleukin in cervical cancer is because their cells express receptors for interleukin - 2 that «fit together» like puzzle pieces with the protein to activate an antitumor response.

They found that during the transition period, cells expressed increasing amounts of a gene encoding the transcription factor Zscan4.