Sentences with phrase «decreased response with»

Not exact matches

The predicted cost savings and investor losses associated with this extension may increase or decrease depending on the information and data received in response to the comment solicitation contained in the March 2017 NPRM.

With each test you are looking to see if it increased or decreased your response rate.

Engineered mice with decreased numbers of 5 - HT neurons and rats or piglets with decreased activity secondary to 5 - HT1A autoreceptor stimulation have diminished ventilator responses to carbon dioxide, dysfunctional heat production and heat - loss mechanisms, and altered sleep architecture.43 These studies linked SIDS risk factors with possible pathophysiology.

Based on these initial findings, we hypothesize that women with decreased insulin sensitivity will experience a more sluggish increase in milk output in response to infant demand as a result of PTPRF overexpression in the mammary gland.

The index also accurately quantified the body's response to increasingly more painful stimulation, with high sensitivity and specificity, as well as showed a decrease when pain medication was administered.

Now, a new University at Buffalo - led study suggests that the moral response produced by the initial exposure to a video game decreases as experience with the game develops.

The HIV - specific IgG3 response correlated with decreased infection risk, but the effect waned over time, similar to the declining efficacy observed in the RV144 trial.

Less p53 decreases the DNA damage response in patients with Li - Fraumeni Syndrome, and Schiffman's team wondered if more p53 could protect against cancer in elephants by heightening the response to damage.

Pharmacogenomics — the study of how genes affect responses to drugs — is becoming more important in drug - development research and clinical trials, with a view toward decreasing side effects and increasing the efficiency and efficacy of drugs in patients with the right genetic profiles.

A weight - loss drug dampened the response to food cues in regions of the brain associated with attention and emotion, leading to decreases in caloric intake, weight and body mass index (BMI), a team led by scientists at Beth Israel Deaconess Medical Center (BIDMC) reported.

The samples taken from patients before transplant had decreased levels of several modules related to basic metabolism and production of chemicals like amino acids and carbohydrates, but were enriched in pathways associated with stress response, compared to donor samples or post-transplant samples.

These findings hold exciting clinical implications.When the researchers blocked the CD36 receptor in mice with atherosclerosis (in which cholesterol thickens the arteries), the cytokine response declined, fewer cholesterol crystals formed in plaques, and inflammation decreased.

In MS patients, Patil and colleagues were expecting a greater tendency for forgiveness, because of difficulty with Theory of mind that has been described in some of these patients, as well as a decrease in empathic response.

To ensure that the DV responses in the controls were consistent with prior findings, we performed a secondary analysis on the effects of MP on the cerebellar DV in an independent cohort of controls, which showed a 12 % reduction, and in a sample of adults with attention deficit hyperactivity disorder (ADHD), which also showed an 11 % reduction (for controls of the current cohort, the cerebellar DV decrease was 13 ± 11 %).

In ventral striatum, these decreases were associated with negative emotionality and with marijuana craving such that the lower the response, the higher the negative emotionality and the craving.

Specifically, compared with controls, marijuana abusers had significantly attenuated behavioral («self - reports» for high, drug effects, anxiety, and restlessness), cardiovascular (pulse rate and diastolic blood pressure), and brain DA [reduced decreases in distribution volumes (DVs) of [11C] raclopride, although normal reductions in striatal nondisplaceable binding potential (BPND)-RSB- responses to MP.

Interestingly, an imaging study comparing DA increases using BPND and 4 - propyl -9-hydroxynaphthoxazine -LRB-[11C] PHNO)(radiotracer with > 20-fold higher affinity for D3 over D2 receptors, and presumably more sensitive to competition with endogenous DA)(63, 64) in response to a stressor in individuals at high risk for schizophrenia showed that those who abused marijuana had a blunted response, consistent with decreased DA signaling (22).

In response to X4 HIV challenge with HIV - 1 Bk132, CD4 counts decreased in both X4 - ZFN and R5 - ZFN mice.

The decreased levels of neutralizing Abs to TMAdV in the researcher (1 ∶ 32) and a family member (1 ∶ 8) relative to those in infected titi monkeys (up to > 1 ∶ 512) are consistent with a recent study showing much higher levels of neutralizing antibodies in chimpanzees than in humans with adenovirus infections, possibly due to more robust adenovirus - specific T - cell responses in humans than in monkeys [45].

Here, we show that marijuana abusers had attenuated behavioral and cardiovascular responses and blunted reductions in striatal DV (although normal reductions in BPND) when challenged with MP compared with controls, which is consistent with decreased brain reactivity to DA stimulation.

Negative regression coefficients for neural response similarity indicate that greater neural response similarity was associated with decreased social distance.

Vaccinating older individuals is problematic, as the effectiveness of most vaccines decrease with age, with maximal responses often as low as 30 % in the over 70s.5 Nevertheless, vaccination programmes demonstrate the ability to reduce disease burden in the elderly as well as offering a tool to observe immune responses in vivo in humans.

But vaccination with selected bacterial proteins plus vitamin A, instead of using live viruses, may be able to decrease the risks and increase the protective response.

Our conclusions related to the «over-estimated» response could be dealt with using a 2x decrease in the assumed forcing, or a 2x decrease in the climate sensitivity, or a 2x increase in the low frequency change in the proxies (although not all at once!).

Children do better than adults with this therapy, and as «we decrease the age, the better the response.»

Relative to samples associated with colonization, those from pneumonia had significantly lower microbial diversity, decreased levels of several bacterial genera and prominent multifunctional cytokine responses.

Quantitative RT - PCR analysis of the de-greening circuit genes (Figure 4E) corroborates the weak response observed in the transgenic plants, with endogenous NtPOR mRNA levels decreasing to approximately one - third of the control levels, and AtRCCR increasing three-fold.

The present neuropathological study reports the second case of meningoencephalitis following immunization with amyloid - beta peptide in AD, and has been directed toward exploring mechanisms underlying decreased tau pathology in relation with amyloid deposit regression, and possible molecular bases involved in the inflammatory response following immunization.

This pattern of decreases is consistent with previous studies that suggest heightened vulnerability of EM - related brain regions in AD, whereas the observed increases in FC may reflect a compensatory response.

Depressed patients showed an increased release of the hormone, while patients with schizophrenia showed a decreased response.

Moreover, changes in the actin structures are typically accompanied by a rounder platelet shape with a highly heterogeneous size, decreased platelet arachidonic response, and spreading and retarded clot retraction in ETV6 deficient platelets.

Observed decreases in arctic sea ice extent have been shown to be inconsistent with simulated internal variability, and consistent with the simulated response to human influence, but SH sea ice extent has not declined.

When contrasting sequences with two levels of embedding against one, we observed decreased behavioural performance and increased BOLD responses in the inferior parietal lobule (IPL) and the middle frontal gyrus (MFG) of the dorsolateral prefrontal cortex (dlPFC).

A decreased heart rate (called bradycardia) is a normal part of the mammalian dive response, along with other physiological changes to conserve oxygen.

Finally, we show that mice with reduced senescence and SASP responses exhibit decreased tumour - inducing potential.

The OPTiM investigators, in an analysis of lesion - level responses, reported that among 2,116 lesions in patients treated with T - VEC, tumor area decreases of ≥ 50 % occurred in 64 % of injected lesions, in 34 % of uninjected nonvisceral lesions, and in 15 % of uninjected visceral lesions.

Allowing people to answer questionnaires in private, with the assurance that their doctor won't see their responses, has been shown to decrease biased responses, they added.

This indication is based on immune response elicited by FLULAVAL, and there have been no controlled trials demonstrating a decrease in influenza disease after vaccination with FLULAVAL.

One of the biggest constraints with IVF in women over 40 is that the number of eggs that grow in response to the stimulation medications used during IVF will decrease as a woman ages because the number of eggs that are available decrease with age.

It also transports cholesterol from extra-hepatic sites, including the arterial wall, to the liver for excretion via reverse cholesterol transport.77 Results from IER (60 - 85 % ER / alternate days) trials have thus far been inconsistent, with some reporting decreases 40, and others increases 37, 39, but with the majority showing no effects on HDL cholesterol levels.38, 42, 43, 45, 49, 51, 52Inconsistencies may have arisen due to the biphasic response of HDL documented by studies of ER induced weight - loss, whereby levels typically decrease during active weight - loss then either return to baseline or (less commonly) rise following attainment of weight stability.78 Complementary increases in HDL levels and particle size have been shown when endurance exercise have been combined with IER 42, 46, 47 however further discussion goes beyond the scope of this review.

Conversely ghrelin, produced mainly by P / D1 cells lining the fundus of the stomach, exerts appetite stimulating effects and so levels are typically at their peak pre-meal and decrease post - prandially.87 As weight - loss is associated with increased fasting levels of ghrelin 88 and reduced suppression in response to a meal in obese subjects 89, changes in circulating ghrelin levels have been assessed in several IER studies.

Importantly, one of the conclusions of this paper was that it was not age per se that correlated highly with cognitive deficits but the diminished level of IGF - 1 and decreased signaling through the insulin response substrate - PI3K and Akt pathways.

Learning and practicing meditation over time helps to decrease stress and turn off the fight or flight response that many people are all too familiar with.

It may sound trivial, but a recent study at the University of Lausanne, Switzerland, revealed that the natural hormone oxytocin — the same chemical that bonds mothers with her young ones in periods of newness — is linked to decreases in «freezing» as a fear response.

However, it was good to see my insulin response is reactive and decreased BG 33 points in 15 minutes to end up with a BG of 120 1 hr after the bread.

Results: With the fasting glucose concentration used as a baseline from which to determine the area under the curve, the high - protein diet resulted in a 40 % decrease in the mean 24 - h integrated glucose area response.

«Both groups improved dyslipidemia, with reduced circulating triglycerides, but showed differential responses in total and low - density lipoprotein cholesterol (decreased in LFHC group only), and high - density lipoprotein cholesterol (increased in VHFLC group only).»

Estriol has been found to have beneficial immune - modulating effects in patients with multiple sclerosis, increasing protective immune responses and decreasing the number and volume of lesions seen in cerebral MRIs.22 Estriol is the primary estrogen produced during pregnancy, when it is made by placenta from 16α - OH DHEA sulfate (DHEA - S), an androgen made in the fetal liver and in the adrenal glands.23

Cancer patients with weakened immune responses have exhibited significant decreases in stress and anxiety which contribute both to a positive emotional response as well as physiological.

The studies that I found on google scholar that talk about omega 6 inflammatory response and the ratio of Omega 6/3 actually recommended a 2 - 3:1 not 1:1 ratio, also they were very clear not to decrease omega 6 intake but rather increase omega 3 intake because the studies showed that rather than omega 6 causing inflammation omega 3 reduced inflammation because the studies were done on people with autoimmune diseases or cancer, not an otherwise healthy person.