Sentences with phrase «development of growth factor»

«Development of growth factor - free tissue adhesive porous films singularly capable of promoting angiogenesis.»

Not exact matches

Important factors that could cause actual results to differ materially from those reflected in such forward - looking statements and that should be considered in evaluating our outlook include, but are not limited to, the following: 1) our ability to continue to grow our business and execute our growth strategy, including the timing, execution, and profitability of new and maturing programs; 2) our ability to perform our obligations under our new and maturing commercial, business aircraft, and military development programs, and the related recurring production; 3) our ability to accurately estimate and manage performance, cost, and revenue under our contracts, including our ability to achieve certain cost reductions with respect to the B787 program; 4) margin pressures and the potential for additional forward losses on new and maturing programs; 5) our ability to accommodate, and the cost of accommodating, announced increases in the build rates of certain aircraft; 6) the effect on aircraft demand and build rates of changing customer preferences for business aircraft, including the effect of global economic conditions on the business aircraft market and expanding conflicts or political unrest in the Middle East or Asia; 7) customer cancellations or deferrals as a result of global economic uncertainty or otherwise; 8) the effect of economic conditions in the industries and markets in which we operate in the U.S. and globally and any changes therein, including fluctuations in foreign currency exchange rates; 9) the success and timely execution of key milestones such as the receipt of necessary regulatory approvals, including our ability to obtain in a timely fashion any required regulatory or other third party approvals for the consummation of our announced acquisition of Asco, and customer adherence to their announced schedules; 10) our ability to successfully negotiate, or re-negotiate, future pricing under our supply agreements with Boeing and our other customers; 11) our ability to enter into profitable supply arrangements with additional customers; 12) the ability of all parties to satisfy their performance requirements under existing supply contracts with our two major customers, Boeing and Airbus, and other customers, and the risk of nonpayment by such customers; 13) any adverse impact on Boeing's and Airbus» production of aircraft resulting from cancellations, deferrals, or reduced orders by their customers or from labor disputes, domestic or international hostilities, or acts of terrorism; 14) any adverse impact on the demand for air travel or our operations from the outbreak of diseases or epidemic or pandemic outbreaks; 15) our ability to avoid or recover from cyber-based or other security attacks, information technology failures, or other disruptions; 16) returns on pension plan assets and the impact of future discount rate changes on pension obligations; 17) our ability to borrow additional funds or refinance debt, including our ability to obtain the debt to finance the purchase price for our announced acquisition of Asco on favorable terms or at all; 18) competition from commercial aerospace original equipment manufacturers and other aerostructures suppliers; 19) the effect of governmental laws, such as U.S. export control laws and U.S. and foreign anti-bribery laws such as the Foreign Corrupt Practices Act and the United Kingdom Bribery Act, and environmental laws and agency regulations, both in the U.S. and abroad; 20) the effect of changes in tax law, such as the effect of The Tax Cuts and Jobs Act (the «TCJA») that was enacted on December 22, 2017, and changes to the interpretations of or guidance related thereto, and the Company's ability to accurately calculate and estimate the effect of such changes; 21) any reduction in our credit ratings; 22) our dependence on our suppliers, as well as the cost and availability of raw materials and purchased components; 23) our ability to recruit and retain a critical mass of highly - skilled employees and our relationships with the unions representing many of our employees; 24) spending by the U.S. and other governments on defense; 25) the possibility that our cash flows and our credit facility may not be adequate for our additional capital needs or for payment of interest on, and principal of, our indebtedness; 26) our exposure under our revolving credit facility to higher interest payments should interest rates increase substantially; 27) the effectiveness of any interest rate hedging programs; 28) the effectiveness of our internal control over financial reporting; 29) the outcome or impact of ongoing or future litigation, claims, and regulatory actions; 30) exposure to potential product liability and warranty claims; 31) our ability to effectively assess, manage and integrate acquisitions that we pursue, including our ability to successfully integrate the Asco business and generate synergies and other cost savings; 32) our ability to consummate our announced acquisition of Asco in a timely matter while avoiding any unexpected costs, charges, expenses, adverse changes to business relationships and other business disruptions for ourselves and Asco as a result of the acquisition; 33) our ability to continue selling certain receivables through our supplier financing program; 34) the risks of doing business internationally, including fluctuations in foreign current exchange rates, impositions of tariffs or embargoes, compliance with foreign laws, and domestic and foreign government policies; and 35) our ability to complete the proposed accelerated stock repurchase plan, among other things.

Such risks, uncertainties and other factors include, without limitation: (1) the effect of economic conditions in the industries and markets in which United Technologies and Rockwell Collins operate in the U.S. and globally and any changes therein, including financial market conditions, fluctuations in commodity prices, interest rates and foreign currency exchange rates, levels of end market demand in construction and in both the commercial and defense segments of the aerospace industry, levels of air travel, financial condition of commercial airlines, the impact of weather conditions and natural disasters and the financial condition of our customers and suppliers; (2) challenges in the development, production, delivery, support, performance and realization of the anticipated benefits of advanced technologies and new products and services; (3) the scope, nature, impact or timing of acquisition and divestiture or restructuring activity, including the pending acquisition of Rockwell Collins, including among other things integration of acquired businesses into United Technologies» existing businesses and realization of synergies and opportunities for growth and innovation; (4) future timing and levels of indebtedness, including indebtedness expected to be incurred by United Technologies in connection with the pending Rockwell Collins acquisition, and capital spending and research and development spending, including in connection with the pending Rockwell Collins acquisition; (5) future availability of credit and factors that may affect such availability, including credit market conditions and our capital structure; (6) the timing and scope of future repurchases of United Technologies» common stock, which may be suspended at any time due to various factors, including market conditions and the level of other investing activities and uses of cash, including in connection with the proposed acquisition of Rockwell; (7) delays and disruption in delivery of materials and services from suppliers; (8) company and customer - directed cost reduction efforts and restructuring costs and savings and other consequences thereof; (9) new business and investment opportunities; (10) our ability to realize the intended benefits of organizational changes; (11) the anticipated benefits of diversification and balance of operations across product lines, regions and industries; (12) the outcome of legal proceedings, investigations and other contingencies; (13) pension plan assumptions and future contributions; (14) the impact of the negotiation of collective bargaining agreements and labor disputes; (15) the effect of changes in political conditions in the U.S. and other countries in which United Technologies and Rockwell Collins operate, including the effect of changes in U.S. trade policies or the U.K.'s pending withdrawal from the EU, on general market conditions, global trade policies and currency exchange rates in the near term and beyond; (16) the effect of changes in tax (including U.S. tax reform enacted on December 22, 2017, which is commonly referred to as the Tax Cuts and Jobs Act of 2017), environmental, regulatory (including among other things import / export) and other laws and regulations in the U.S. and other countries in which United Technologies and Rockwell Collins operate; (17) the ability of United Technologies and Rockwell Collins to receive the required regulatory approvals (and the risk that such approvals may result in the imposition of conditions that could adversely affect the combined company or the expected benefits of the merger) and to satisfy the other conditions to the closing of the pending acquisition on a timely basis or at all; (18) the occurrence of events that may give rise to a right of one or both of United Technologies or Rockwell Collins to terminate the merger agreement, including in circumstances that might require Rockwell Collins to pay a termination fee of $ 695 million to United Technologies or $ 50 million of expense reimbursement; (19) negative effects of the announcement or the completion of the merger on the market price of United Technologies» and / or Rockwell Collins» common stock and / or on their respective financial performance; (20) risks related to Rockwell Collins and United Technologies being restricted in their operation of their businesses while the merger agreement is in effect; (21) risks relating to the value of the United Technologies» shares to be issued in connection with the pending Rockwell acquisition, significant merger costs and / or unknown liabilities; (22) risks associated with third party contracts containing consent and / or other provisions that may be triggered by the Rockwell merger agreement; (23) risks associated with merger - related litigation or appraisal proceedings; and (24) the ability of United Technologies and Rockwell Collins, or the combined company, to retain and hire key personnel.

Factors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to: changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining of the Company's vendor base and execution of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the amount that we invest in strategic transactions and the timing and success of those investments; the integration of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn; changes in the competitive market and competition amongst retailers; changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website; changes in existing tax, labor and other laws and regulations, including those changing tax rates and imposing new taxes and surcharges; limitations on the availability of attractive retail store sites; omni - channel growth; unauthorized disclosure of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled cFactors that could cause actual results to differ materially from those expressed or implied in any forward - looking statements include, but are not limited to: changes in consumer discretionary spending; our eCommerce platform not producing the anticipated benefits within the expected time - frame or at all; the streamlining of the Company's vendor base and execution of the Company's new merchandising strategy not producing the anticipated benefits within the expected time - frame or at all; the amount that we invest in strategic transactions and the timing and success of those investments; the integration of strategic acquisitions being more difficult, time - consuming, or costly than expected; inventory turn; changes in the competitive market and competition amongst retailers; changes in consumer demand or shopping patterns and our ability to identify new trends and have the right trending products in our stores and on our website; changes in existing tax, labor and other laws and regulations, including those changing tax rates and imposing new taxes and surcharges; limitations on the availability of attractive retail store sites; omni - channel growth; unauthorized disclosure of sensitive or confidential customer information; risks relating to our private brand offerings and new retail concepts; disruptions with our eCommerce platform, including issues caused by high volumes of users or transactions, or our information systems; factors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled cfactors affecting our vendors, including supply chain and currency risks; talent needs and the loss of Edward W. Stack, our Chairman and Chief Executive Officer; developments with sports leagues, professional athletes or sports superstars; weather - related disruptions and seasonality of our business; and risks associated with being a controlled company.

Even so, we anticipate that housing market developments will be a factor at work in reducing the rapid pace of growth in domestic spending to something more moderate.

Our future capital requirements may vary materially from those currently planned and will depend on many factors, including our rate of revenue growth, the timing and extent of spending on research and development efforts and other business initiatives, the expansion of sales and marketing activities, the timing of new product introductions, market acceptance of our products and overall economic conditions.

Eventually I got hold of Christian Schwarz's book «Natural Church Development» which was developed based on his research with thousands of churches across the world looked at the «quality» of churches because his findings seemed to surprisingly indicate that the quality of a church was the number one factor in the nemerical growth of a church.

Other factors clearly played a part in this development, not least the unrelated growth, during this period, in the numbers of independent women who had the freedom to join a new cult such as Christianity.

This approach attempts to trace the origin and growth of religious ideas and institutions through definite periods of historical development and to assess the role of the factors with which religion interacted during these times.

For us, the development of organic agriculture is a key element has been a key contributing factor to the growth of more environmentally - friendly practices.

The development in this larger, wide mouth neck finish is driven by the combination of three factors: - the continuous growth of aseptically processed, shelf stable beverages such as juices, drinkable dairy, Ready - To - Drink coffees and teas, preservative free drinks and water - the dynamic growth of on - the - go beverage consumption in single serve packaging formats - and the increasing consumer demand for on - the - go beverage convenience, hygiene and resealablity provided by a flip - top sport cap with a larger neck finish for superior hydration.

Factors such as population growth, growing demand for automation and machinery optimisation, as well as a rise in e-commerce is fuelling this development,» said Jorge Izquierdo, VP of Market Developmedevelopment,» said Jorge Izquierdo, VP of Market DevelopmentDevelopment at PMMI.

The role of bioactive components, such as cytokines, hormones, growth factors (GFs) and fatty acids (FAs) is poorly known, but they might be implicated in immune response development.

Growth and development of babies are dependent on several factors such as optimal nutrition, prevention from diseases and overall healthy living.

Together, they are embarking on a mission to provide children in impoverished regions of the country with opportunities and resources to integrate purposeful play into their everyday lives; a factor proven critical in children's emotional, physical and cognitive development and future growth.

She pointed out that there are experts dealing with various factors that influence the healthy growth and development of babies, but as a mother herself, she stressed the importance of «human touch» in caring and nurturing children.

Another reason not to fixate on a number on a growth chart is that your baby's well - being involves a variety of factors, including development, temperament, and activity level, not just growth.

Growth factors and the development of neonatal host defense.

Breastfeeding is an unequalled way of providing ideal food for the healthy growth and development of infants1, providing protection from morbidity and mortality due to infectious diseases2 and chronic diseases later in life.3 Exclusive breastfeeding is recommended, starting within one hour of birth and for the first 6 months of life, with continued breastfeeding to 2 years of age and beyond.4 However, rates of initiation, exclusive breastfeeding and breastfeeding duration have fallen since the widespread introduction and promotion of breast - milk substitutes.5 Successful breastfeeding depends on a number of factors, including a re-normalisation of breastfeeding as the infant feeding method of choice through antenatal counselling and education and breastfeeding support to prevent and resolve breastfeeding difficulties.

They address the developmental growth of any child, describe strengths based approaches to support the development of protective factors that keep families strong, depict parenting practices that support healthy child development, and encourage cultural sensitivity in parent educators / home visitors.

Research shows that the growth of our babies brains (DNA synthesis) happen rapidly during the first few years of life, along with nerve growth factors which is a hormone that facilitates development And how are both of these promoted?

The growth in our babies brains happens incredibly quickly during the first few years of life, along with nerve growth factors including a hormone that facilitates development.

He advised that each student should factor himself into being part of that future by making personal efforts at growth and development nurtured through education, which he described as the most portent tool for competition in the world...

To get more cells, researchers from Advanced Cell Technology in Worcester, Mass., grew clusters of human embryonic cells in a precise cocktail of growth factors and other cell - regulating chemicals that took several years to work out, says Robert Lanza, the firm's vice president of research and scientific development.

«The ability to repeatedly and non-destructively measure root systems in the mini-Horhizotron can provide valuable insight into the process of root growth and development and the factors that influence it,» the scientists said.

It seemed so obvious that if fairly small changes in development, which adjusted the timing and concentrations of growth and signaling factors, could have led to the evolution of birds from nonavian dinosaurs, we could readjust those changes in development and get a dinosaur from a chick embryo.

Since it is known that 13 different members of the fibroblast growth factor, or Fgf, family act as signaling proteins between the two different tissues — dental mesenchyme and oral epithelium — during murine tooth development, Javed and colleagues looked for changes in Fgf ligands in the mice lacking Sp7.

In a recent study, Granger and scientists with the University of Oregon tracked the release of nerve growth factor in saliva (sNGF), finding for the first time that this protein typically linked to the survival, development or function of neurons may be an important player in understanding the body's response to stress.

Dolmetsch exposes these stem cells to a variety of different growth factors that mimic those that induce stem cells to become neurons during normal development.

Researchers at the San Diego Supercomputer Center (SDSC) and the Moores Cancer Center at the University of California, San Diego, have described for the first time the molecular mechanism of cancer development caused by well - known «resistance» mutations in the gene called epidermal growth factor receptor (EGFR).

This fibroblast - growth - factor pathway plays a crucial role in controlling development, beginning in early development of the embryo and extending through the bone - growth phase after the giraffe is born.

A related study, also published in PLOS Genetics, shows that RPM - 1 functions as a part of a novel pathway to control β - catenin activity — this is the first evidence that RPM - 1 works in connection with extracellular signals, such as a family of protein growth factors known as Wnts, and is part of larger signaling networks that regulate development.

«The most intriguing of these genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth factors — a family of regulators involved in regulating many processes including embryo development,» Cavener said.

They promote the growth of cancerous cells by releasing growth factors and increasing the response of certain proteins that regulate tumor cell development (oncoproteins).

But as I said, this is only interesting in terms of a new treatment if these growth factors still have a role to play in the growth and development of the lymphoma after diagnosis.»

Bettencourt and his colleagues at Arizona State University (A.S.U.), Dresden University of Technology in Germany and New Mexico's Santa Fe Institute, modeled the growth of a city according to three categories of factors: material infrastructure (road surfaces, electrical cable, etc.), human needs (such as total energy consumption and housing) and patterns of social activity, including total bank deposits, research and development, new cases of AIDS and new patents filed.

Growth in insects and many other animals depends on environmental factors, such as the availability of food during development.

Su - chun Zhang and his colleagues at the University of Wisconsin, Madison, and the University of Bonn, Germany, directed the development of embryonic stem cells stage by stage, using the same growth factors the body uses.

It needs to be understood that development is a multifaceted process, and a number of factors must dovetail together before economic growth and progress can occur.

This could be because the brains of mammals lack the pre cursor cells or the growth factors that control and support the development of projection neurons.

Rivolta and his colleagues knew that during embryonic development, a handful of proteins, including fibroblast growth factor (FGF) 3 and 10, are required for ears to form.

They first induced angiogenesis in mice through the injection of a growth factor called FGF - 2 and measured blood vessel development in the presence and absence of synthesised IP5.

He said scientists are still learning how this growth factor controls healing, and ultimate development of the discovery as a healing agent or vaccine was still a number of years away.

Heparanase dysfunction is linked to the spread of cancers both through the breakdown of this matrix and via the subsequent release of «growth factors» — chemicals that promote tumour development.

«We found that IL - 34 is an essential growth factor for the differentiation of Langerhans cells and microglia during embryonic development,» says senior author Marco Colonna, MD, professor of medicine and of pathology and immunology.

His basic research on growth factors is key to the development of the chemotherapy drug Cetuximab (Erbitux).

Vascular endothelial growth factor signaling is necessary for expansion of medullary microvessels during postnatal kidney development.

In 1989, the gene for vascular endothelial growth factor (VEGF) is identified, leading to the development of anti-angiogenesis treatments including bevacizumab (Avastin) for cancer.

Anna Huttenlocher, University of Wisconsin, USA Neutrophils in the Tumor Microenvironment Neutrophils, Wounds, and Cancer Progression Stefan Kaufmann, Max Planck Institute, Germany Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells Kathryn Moore, New York University, USA MicroRNA -33-dependent regulation of macrophage metabolism directs immune cell polarization in atherosclerosis Lalita Ramakrishnan, University of Cambridge, UK Myeloid Growth Factors Promote Resistance to Mycobacterial Infection by Curtailing Granuloma Necrosis through Macrophage Replenishment Beth Stevens, Harvard University, USA Microglia: Dynamic Mediators of Synapse Development and Plasticity Do glia drive synaptic and cognitive impairment in disease?

Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats.