Diabetes is a systemic disease affecting all parts of the body, including the eye and may lead to vision loss.
«The root cause of type 2
diabetes is systemic inflammation, which impacts insulin secretion and function,» said lead author Professor Manohar Garg, a scientist of Indian origin.
Not exact matches
Those diseases
are:
systemic lupus erythematosus (SLE), multiple sclerosis (
MS), rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), inflammatory bowel disease (IBD), celiac disease, and type 1
diabetes.
«In the study we challenged the view that the age - dependent impairment in glucose homeostasis
is solely due to intrinsic, dysfunction of islet cells, and hypothesized that it
is instead affected by
systemic aging factors,» says first author Joana Almaca at the
Diabetes Research Institute, University of Miami.
Past research by Olefsky and others has shown that obesity
is characterized by low - grade inflammation in adipose or fat tissues and that this inflammatory state can become chronic and result in
systemic insulin resistance and
diabetes.
Systemic lupus erythematosus, type I
diabetes mellitus and sarcoidosis
were the most common nonceliac autoimmune diseases seen in patients.
Today, moderate to severe periodontal disease affects more than 10 % of the world's population and
is linked to diverse
systemic diseases, including cardiovascular disease, stroke, pulmonary disease, and type II
diabetes.
It
's hoped this latest insight will lead to the widespread use of antigen - specific immunotherapy as a treatment for many autoimmune disorders, including multiple sclerosis (
MS), type 1
diabetes, Graves» disease and
systemic lupus erythematosus (SLE).
Although not directly evaluated in this study, the association between circulating estrogen and
diabetes risk could
be attributed to
systemic estrogen resistance in men (63).
Diabetes develops when
systemic insulin concentrations
are insufficient to control blood glucose homeostasis.
In specific examples, the method 100 can
be used for characterization of and / or therapeutic intervention for one or more of: acquired immune deficiency syndrome (AIDS), asthma, rheumatoid arthritis, Sprue, Sjogren's syndrome, multiple sclerosis, Type I
diabetes, and
systemic Lupus erythmatosus.
Could we have this
systemic inflammation thing happening and pain may
be the first indicator for people that have that genetic predisposition, but we also see autoimmune issues, maybe even type I
diabetes or
MS, so how many other — they call it PGAS or polyglandular autoimmune syndrome and they say, I think 78 % of people that have one autoimmune condition, maybe it
's RA or some type of fibromyalgia pain, probably have another one, how much of the people — patients that you
're seeing individually in your office
are having more than just the pain?
Recognition
is growing that, because they
are common antecedents for the initiation of atherosclerosis and type 2
diabetes,
systemic inflammation and endothelial dysfunction may
be 2 integral components of the metabolic syndrome, (19, 20).
This type of diet
is used successfully in the treatment of not only unwanted body fat, belly fat, and obesity, but also many diseases and conditions such as acne, mood swings, depression, lack of energy, type 2
diabetes, insulin resistance, hyperactivity, asthma, food cravings, joint pains, arthritis,
systemic lupus erythematosus (SLE), irritable bowel syndrome (IBS), menopause, irritability, restless legs, allergies, inflammation, food addictions, carbohydrate cravings, binge eating, etc..
Systemic inflammation
was recently reported to
be involved in the incidence of atherosclerosis (1), coronary heart disease (2),
diabetes (3), and the metabolic syndrome (4).
Low vitamin D in the body
is linked to a higher risk for developing chronic illnesses, both
systemic disease (lupus, arthritis) and organ - specific (multiple sclerosis,
diabetes).
Well, the good news
is, antioxidants help to eliminate the threat of free radical damage — which in turn reduces our risk for developing diseases such as, heart disease, Alzheimer's disease, dementia, cancer,
diabetes and
systemic infections.
And it
is so much more detrimental than just bouts of «hanger» and mid-afternoon crashes: it
is without a doubt one of the biggest culprits behind our nation's soaring rates of obesity, type II
diabetes, and inflammatory disease (since the blood sugar rollercoaster creates
systemic inflammation).
It
was found to
be associated with multiple autoimmune diseases including rheumatoid arthritis,
systemic lupus erythematosus, type 1
diabetes, Graves» disease and Hashimoto's thyroiditis.
The gene
was found to
be associated with a variety of autoimmune conditions such as type 1
diabetes, asthma, Addison's disease, myasthenia gravis, Sjorgren's syndrome,
systemic lupus erythematosus (SLE),
systemic sclerosis, ulcerative colitis and all forms of AITD including Grave's disease and Hashimoto's thyroiditis.
There
is increasing epidemiologic evidence linking vitamin D deficiency and autoimmune diseases including multiple sclerosis, rheumatoid arthritis, type 1
diabetes, inflammatory bowel disease and
systemic lupus (source).
In addition, researchers observed that overgrowth of firmicutes led to chronic
systemic inflammation, which
is known to contribute to common health problems such as metabolic syndrome,
diabetes and heart disease.
The Paleolithic Diet
is not only used successfully in the treatment of weight and obesity, but also type 2
diabetes, irritable bowel syndrome (IBS),
systemic lupus erythematosus (SLE), allergies, acne, asthma, menopause, inflammation, arthritis, joint pains, carbohydrate cravings, binge eating, food addictions, mood disorders and many other health conditions.
There
are some other medical conditions such as hypothyroidism, myxedema,
Systemic lupus erythematosus (SLE), thyroid cancer, thyrotoxicosis, rheumatoid arthritis, pernicious anemia, autoimmune collagen vascular disease and type 1
diabetes where the level of thyroid antibodies
is mild to moderately elevated.
In a study published by the National Institutes of Health, «TFA (Trans Fatty Acid) intake
is positively associated with markers of
systemic inflammation... (the) influences of TFAs on inflammation and of implications for coronary disease,
diabetes, and other conditions
is warranted.»
Often, an associated underlying immunosuppressive disease, such as FIV, FeLV,
diabetes mellitus, hyperadrenocorticism, toxoplasmosis,
systemic lupus erythematosus, or squamous cell carcinoma in situ
is present in patients with generalized disease.3
Budesonide may cause less of the
systemic side effects we associate with corticosteroid use and
be less likely to cause
diabetes in cats.
Below
are some of the common specialty areas that we have experience with: - Infectious diseases: Tick - borne disease (Lyme disease, Ehrlichiosis, Rocky Mountain Spotted Fever, Bartonella),
systemic and local bacterial infections, feline and canine viral disease - Hematology: Immune - mediated hemolytic anemia, thrombocytopenia, leukemia, bone marrow diseases - Oncology: Surgical and chemotherapy management, lymphoma, mast cell tumors, hemangiosarcoma, osteosarcoma, fibrosarcoma, mammary neoplasia, as well as benign and malignant skin masses such as adenomas and cysts - Urology: Kidney failure, bladder infections, stones / crystals, prostatic disease, pyelonephritis, FLUTD, protein - losing nephropathy, glomerulonephritis - Endocrine: Hormonal diseases such as hyper - and hypothyroidism,
diabetes mellitus, cushings disease, addison's disease, endocrine skin disease - Gastroenterology: Chronic vomiting and / or diarrhea, inflammatory bowel disease (IBD), stomach ulcers / gastritis, colitis, pancreatic disorders, liver disease, protein - losing enteropathy - Respiratory disease: Feline asthma, canine chronic bronchitis, upper respiratory viral disease, pleural effusion, laryngeal paralysis - Cardiology: Heart murmurs and arrhythmias, heart failure, heartworm disease, hypertension - Ophthalmology: Gaucoma, cataracts, uveitis, corneal disease, ocular surgery - Allergic disease: Allergic dermatitis, food allergies, flea allergy, and allergic gastrointestinal and respiratory disease
This will
be done to rule out
systemic illnesses such as distemper,
diabetes, and liver disease.
Renal failure in dogs can
be brought about by a variety of conditions such as Lyme disease,
systemic lupus erythematosus,
diabetes mellitus, chronic gastrointestinal diseases, genetic abnormalities, hypertension, and even skin infections.
I've talked about what could happen if bad breath isn't properly treated, but if you
're brushing your dog's teeth and seeing no signs of bacteria build - up, your dog could
be suffering from a
systemic disease such as
diabetes or kidney failure.
Causes of glucosuria
are Diabetes, tumours of the pancreas, inflammation of the pancreas, congenital problems,
systemic disease, hormone imbalance, infections, poisoning and liver failure.
ACT - activated clotting time (bleeding disorders) ACTH - adrenocorticotropic hormone (adrenal gland function) Ag - antigen test for proteins specific to a disease causing organism or virus Alb - albumin (liver, kidney and intestinal disorders) Alk - Phos, ALP alkaline phosphatase (liver and adrenal disorders) Allergy Testing intradermal or blood antibody test for allergen hypersensitivity ALT - alanine aminotransferase (liver disorder) Amyl - amylase enzyme — non specific (pancreatitis) ANA - antinuclear antibody (
systemic lupus erythematosus) Anaplasmosis Anaplasma spp. (tick - borne rickettsial disease) APTT - activated partial thromboplastin time (blood clotting ability) AST - aspartate aminotransferase (muscle and liver disorders) Band band cell — type of white blood cell Baso basophil — type of white blood cell Bile Acids digestive acids produced in the liver and stored in the gall bladder (liver function) Bili bilirubin (bile pigment responsible for jaundice from liver disease or RBC destruction) BP - blood pressure measurement BUN - blood urea nitrogen (kidney and liver function) Bx biopsy C &
S aerobic / anaerobic bacterial culture and antibiotic sensitivity test (infection, drug selection) Ca +2 calcium ion — unbound calcium (parathyroid gland function) CBC - complete blood count (all circulating cells) Chol cholesterol (liver, thyroid disorders) CK, CPK creatine [phospho] kinase (muscle disease, heart disease) Cl - chloride ion — unbound chloride (hydration, blood pH) CO2 - carbon dioxide (blood pH) Contrast Radiograph x-ray image using injected radiopaque contrast media Cortisol hormone produced by the adrenal glands (adrenal gland function) Coomb'
s anti- red blood cell antibody test (immune - mediated hemolytic anemia) Crea creatinine (kidney function) CRT - capillary refill time (blood pressure, tissue perfusion) DTM - dermatophyte test medium (ringworm — dermatophytosis) EEG - electroencephalogram (brain function, epilepsy) Ehrlichia Ehrlichia spp. (tick - borne rickettsial disease) EKG, ECG - electrok [c] ardiogram (electrical heart activity, heart arryhthmia) Eos eosinophil — type of white blood cell Fecal, flotation, direct intestinal parasite exam FeLV Feline Leukemia Virus test FIA Feline Infectious Anemia: aka Feline Hemotrophic Mycoplasma, Haemobartonella felis test FIV Feline Immunodeficiency Virus test Fluorescein Stain fluorescein stain uptake of cornea (corneal ulceration) fT4, fT4ed, freeT4ed thyroxine hormone unbound by protein measured by equilibrium dialysis (thyroid function) GGT gamma - glutamyltranferase (liver disorders) Glob globulin (liver, immune system) Glu blood or urine glucose (
diabetes mellitus) Gran granulocytes — subgroup of white blood cells Hb, Hgb hemoglobin — iron rich protein bound to red blood cells that carries oxygen (anemia, red cell mass) HCO3 - bicarbonate ion (blood pH) HCT, PCV, MHCT hematocrit, packed - cell volume, microhematocrit (hemoconcentration, dehydration, anemia) K + potassium ion — unbound potassium (kidney disorders, adrenal gland disorders) Lipa lipase enzyme — non specific (pancreatitis) LYME Borrelia spp. (tick - borne rickettsial disease) Lymph lymphocyte — type of white blood cell MCHC mean corpuscular hemoglobin concentration (anemia, iron deficiency) MCV mean corpuscular volume — average red cell size (anemia, iron deficiency) Mg +2 magnesium ion — unbound magnesium (
diabetes, parathyroid function, malnutrition) MHCT, HCT, PCV microhematocrit, hematocrit, packed - cell volume (hemoconcentration, dehydration, anemia) MIC minimum inhibitory concentration — part of the C&
S that determines antimicrobial selection Mono monocyte — type of white blood cell MRI magnetic resonance imaging (advanced tissue imaging) Na + sodium ion — unbound sodium (dehydration, adrenal gland disease) nRBC nucleated red blood cell — immature red blood cell (bone marrow damage, lead toxicity) PCV, HCT, MHCT packed - cell volume, hematocrit, microhematocrit (hemoconcentration, dehydration, anemia) PE physical examination pH urine pH (urinary tract infection, urolithiasis) Phos phosphorus (kidney disorders, ketoacidosis, parathyroid function) PLI pancreatic lipase immunoreactivity (pancreatitis) PLT platelet — cells involved in clotting (bleeding disorders) PT prothrombin time (bleeding disorders) PTH parathyroid hormone, parathormone (parathyroid function) Radiograph x-ray image RBC red blood cell count (anemia) REL Rocky Mountain Spotted Fever / Ehrlichia / Lyme combination test Retic reticulocyte — immature red blood cell (regenerative vs. non-regenerative anemia) RMSF Rocky Mountain Spotted Fever SAP serum alkaline phosphatase (liver disorders) Schirmer Tear Test tear production test (keratoconjunctivitis sicca — dry eye,) Seg segmented neutrophil — type of white blood cell USG Urine specific gravity (urine concentration, kidney function) spec cPL specific canine pancreatic lipase (pancreatitis)-- replaces the PLI test spec fPL specific feline pancreatic lipase (pancreatitis)-- replaces the PLI test T4 thyroxine hormone — total (thyroid gland function) TLI trypsin - like immunoreactivity (exocrine pancreatic insufficiency) TP total protein (hydration, liver disorders) TPR temperature / pulse / respirations (physical exam vital signs) Trig triglycerides (fat metabolism, liver disorders) TSH thyroid stimulating hormone (thyroid gland function) UA urinalysis (kidney function, urinary tract infection,
diabetes) Urine Cortisol - Crea Ratio urine cortisol - creatine ratio (screening test for adrenal gland disease) Urine Protein - Crea Ratio urine protein - creatinine ratio (kidney disorders) VWF VonWillebrands factor (bleeding disorder) WBC white blood cell count (infection, inflammation, bone marrow suppression)
Systemic diseases which have
been linked to periodontal disease include: renal, hepatic, pulmonary, and cardiac diseases; osteoporosis, adverse pregnancy effects, and
diabetes mellitus.
Although greater early local production of proinflammatory cytokines at wound sites
is beneficial because it
is associated with enhanced healing, greater
systemic production of proinflammatory cytokines can represent a maladaptive response.24 Both physical and psychological stressors can provoke transient increases in plasma levels of proinflammatory cytokines, particularly IL - 6,25 as can negative emotions like depression and anxiety.26 - 28 More frequent or persistent stress - related changes have broad implications for physical and mental health; sustained elevated levels of proinflammatory cytokines have
been linked to a variety of age - related diseases, including cardiovascular disease, osteoporosis, arthritis, type 2
diabetes mellitus, certain cancers, and frailty and functional decline.29 - 31