Sentences with phrase «driven change cycles»

RICC, short for Rapid Inquiry - Driven Change Cycle ® is a component of the Success Now!

The leadership team applied a rapid inquiry - driven change cycle (RICC) involving diagnostic data and root cause analyses, planning, testing, and collaborative reflection on near - term results.

Not exact matches

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

The changing risk profile of high yield means future market cycles will increasingly be driven by technical, in addition to fundamental, events.

The central message of our discipline is that valuations are enormously informative about prospects for long - term and full - cycle returns, but that outcomes over shorter segments of the market cycle are driven by changes in the psychological preferences of investors toward speculation or risk - aversion.

If Lu's suggestion is correct, ozone levels should fall then rise every 11 years, in step with changes in cosmic - ray intensity driven by the 11 - year solar cycle.

Cycles that drive changes in the ocean's chemistry and organisms take place over hours, days, seasons, years and even decades — timescales NEPTUNE can track.

The Sun's activity — including changes in the number of sunspots, levels of radiation and ejection of material - varies on an eleven - year cycle, driven by changes in its magnetic field.

While Antarctic ice shelves are in direct contact with both the atmosphere and the surrounding oceans, and thus subject to changes in environmental conditions, they also go through repeated internally - driven cycles of growth and collapse.

Lyons observed that temperature changes and erratic weather drive a cycle that could further worsen allergy risks.

Taking factors such as sea surface temperature, greenhouse gases and natural aerosol particles into consideration, the researchers determined that changes in the concentration of black carbon could be the primary driving force behind the observed alterations to the hydrological cycle in the region.

«It's the engine that drives the carbon cycle for the whole world, which makes it important when we discuss climate changes.

Researchers in Hawaii found that guppies released in the 1920s drove down native fish populations, perhaps by competing with them for food and living space, and had likely changed the cycle of nutrients in water: Guppy - rich areas showed increased levels of dissolved nitrogen — from ammonium in fish urine and gill excretions — which, in turn, stimulated algae growth.

There is some evidence that the ice came and went in regular cycles, driven by changes in Earth's orbit.

The change is driven by differently timed fruiting cycles between apple trees, which some Rhagoletis prefer, and the North American hawthorn, the native fruit where Rhagoletis have traditionally laid their eggs.

Since changes in the soil nitrogen cycle are driven by microbes, could bacteria associated with invasive species not only be responsible for the observed changes in soil nutrient concentrations, but also for enabling the continued growth and persistence of the invader species?

«Driving factors behind changes between local and global carbon cycles.»

The 20,000 - year cycle is driven by changes in the Earth's orbit around the sun, which affects the amount of sunlight received during any particular season.

Kirchhoff's law only applies when there is thermodynamic equilibrium, and that does not apply to the air near the surface of the Earth when the thermal radiation is constantly changing, driven by a diurnal solar cycle.

The 11 years solar cycle acts an important driving force for variations in the space weather, ultimately giving rise to climatic changes.

Our core strengths in green chemistry and engineering research, combined with our role as a trusted third - party facilitator of stakeholder collaborations drives meaningful change toward solutions that 1) preserve natural capital, 2) are safe and sustainable across the product life cycle, 3) align and leverage different types of policy instruments, and 4) actively engage stakeholders to ensure equity.

So we have the national «liberal» media, like the NYT and NBC, blowing this story, while the local, conservative media get it right, see «conservative San Diego Union knows climate change is killing Western forests» and «Oldest Utah newspaper: Bark - beetle driven wildfires are a vicious climate cycle.»

Find out exactly how orgasm can heal your hormones, why you might be self - pleasuring the wrong way, what the 5 different kinds of orgasms are and how you can have them, & how to navigate your sex drive throughout your life cycle and changing hormonal patterns.

Irregular cycles, spotting, decreased sex drive, vaginal dryness, heavy periods, light periods, breast changes, hot flashes, night sweats, insomnia, brain fog, or belly fat.

Directly, that translates to 372 miles, though VW notes in the U.S. driving cycle it's likely to be rated at 270 miles unless driving range calculations suddenly change between now and when a production version of the BUZZ goes on sale.

The 2016 Chevrolet Malibu Hybrid (earlier post) is EPA - rated at 46 mpg (5.11 l / 100 km) combined, 47 mpg city and 46 mpg highway; the powertrain shares the transmission architecture with the 2016 Chevrolet Volt extended range electric vehicle (EREV), but includes changes to optimize the system for engine - driven charge - sustaining operation in the range of conditions represented by the US EPA 5 cycle fuel economy tests.

For 2016 the EPA changed how it rates hybrids with tougher drive cycles.

Dealer scheduled maintenance comes in alternating schedule A and schedule B cycles, with the schedule A maintenance being the basic oil change and fluids top off and the schedule B maintenance being more thorough with lubing the chassis and checking the suspension and drive chain for repair and replacement needs.

Throughout its nearly 10 year life cycle a few changes came to alter the skin of the Honda S2000 but it never lost the hardcore driving enthusiasts, it never lost the FR layout, it never lost the 50:50 weight distribution and, most importantly, it never lost its six speed manual gearbox.

«We worked a lot on all of the lighting in the world and we have a full day and night cycle, a full weather system, it's based on the server, and we wanted to make sure that as soon as you are driving and piloting, the experience you have when you are free driving is changing all the time, it's living, it's the feeling you want to have when exploring the world.

Given that the Milankovitch TSI forcing is less than + - 0.1 %, while nonetheless driving ice - age cycles, the current anthro forcing of > 0.85 W / m ^ 2 (> +0.2 %) can hardly be called «a small change in forcing».

Although the primary driver of glacial — interglacial cycles lies in the seasonal and latitudinal distribution of incoming solar energy driven by changes in the geometry of the Earth's orbit around the Sun («orbital forcing»), reconstructions and simulations together show that the full magnitude of glacial — interglacial temperature and ice volume changes can not be explained without accounting for changes in atmospheric CO2 content and the associated climate feedbacks.

They have very little to do with the long term trend (driven by fossil fuel burning) but are important for understanding the sensitivity of the carbon cycle to changes in climate.

Milankovitch forcings are well accepted, and are understood to be the driving forces controlling the glacial - interglacial cycles, see Loutre and Berger (2000) for one of the latest discussions of this and the relevance to future climate change.

[Response: To pre-empt some mutual incomprehension, note that industrial CO2 rises are certainly an anthropgenic forcing and not a response (see here and here), but clearly CO2 changes over glacial - interglacial cycles is both a response (to Milankovitch - driven changes) and a forcing (since the additional radiative forcing from CO2 is about a third of that needed to keep the ice ages as cold as they are — see here).

Solar cycle length Veizer suggests the recent global warming might be driven by changes in solar activity (his Fig. 14a — dashed line is temperature, solid line with diamonds is solar cycle length).

These shape the 4 - dimensional pattern of temperature and other changes — the patterns of circulation, latent heating, and precipitation will shift, as can the cycles driven the imposed diurnal and seasonal cycles in incident solar radiation; the texture of internal variability can also shift.

The implications of our findings are that the modern observations of ocean - driven warming along the western Antarctic Peninsula need to be considered as part of a natural centennial timescale cycle of climate variability, and that in order to understand climate change along the Antarctic Peninsula, we need to understand the broader climate connections with the rest of the planet.

I was aware of Milankovitch cycles and their role in driving ice ages and so I was somewhat confused by Al Gore's implicit attribution of global temperature changes to CO2 in An Inconvenient Truth.

Researchers are confident that they understand the cycle of Ice Ages, and they also have a clear idea that the biosphere plays a hand in keeping the planet at liveable temperatures, but they also know that the high altitudes are more than usually affected by climate change driven by ever - higher ratios of greenhouse gases released by the combustion of fossil fuels by seven billion humans.

It is essential that some studies now begin to assess, understand and calibrate the powerful, complex, interrelated natural forces that drive climate fluctuations, cycles and changes.

Foreword by Dr, F, James Rutherford American association for the Advancement of Science «Astronomical Cycle: Scientists believe astronomical cycles touch off changes in the ocean - Atmosphere system that drives the world's climate.

Researchers have also known about and documented periodic shifts over cycles of 21,000 years, 41,000 years and 100,000 years, all of them also driven by astronomical change.

Natural cycles driven largely by the sun and complex systems of forcings and feedbacks account for such changes.

«This paper presents simulations of climate change with an ensemble of GCMs driven by the A1FI scenario, and also assesses the implications of carbon - cycle feedbacks for the climate - change projections.

Three of the five scientists affirmed that changes in climate patterns are driven by natural cycles and are not impacted by humans.

We'd driving the models with the GHG concentrations, and using carbon cycle models within the climate models to simulate the natural carbon fluxes (atmosphere - land and atmosphere - ocean), which themselves are affected by the simulated climate change, and the residual needed to balance the carbon budget then indicates the anthropogenic emissions that would give the prescribed scenario of CO2 rise.

The complete set of cycles appears to be solar driven however there are different solar mechanisms involved which explains the differences in the cycle times and the differences in the amount of climate change for the different solar events.

I will stick with concept that Weather is Climate... so that the climate changes as the weather changes... and the Sun drives the weather through daily, seasonal, solar and Milankovitch cycles.

They discovered that while some natural climate cycles could partly explain reduced rainfall and desert expansion southward, human - driven climate change is also playing a part.