Sentences with phrase «drug candidate targeting»

Enterome's EB8018, a First - in - class Drug Candidate Targeting Crohn's Disease, Successfully Completes Phase I Study in Healthy Volunteers — Enterome — Cision (same as above link, more detail)

The Unit's scientific mission covers the design, synthesis, molecular modeling, as well as biophysical, biochemical and cellular studies of small - molecule probes and drug candidates targeting nucleic acids or proteins involved in cancer.

Not exact matches

Zymeworks will be putting its two leading drug candidates, both targeted at breast cancer, into clinical trials in the next few months.

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

Key findings presented at AACR included sustained peripheral NK and T cell expansion, doses were well - tolerated and the drug candidate's role as a long - acting CD122 agonist without targeting CD25.

To generate a rich source of potential vaccine and drug target candidates, the team identified a set of genes that are more active in certain stages of the parasite life cycle and within the parasite's gut.

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have designed two new drug candidates to target prostate and triple negative breast cancers.

He says that using a liquid biopsy test that was developed and now offered at Dana - Farber Cancer Institute, he was able to determine that the patient did indeed have the mutation, making her a good candidate for drugs that target it.

The three remaining drug candidates that target amyloid - β are currently being tested in people with Alzheimer's, as well as in individuals who have a high risk of developing the disease but who have not yet developed symptoms.

But new candidate antiaddiction drugs target the neural circuitry of addiction itself.

However, CiRA researchers from Professor Junya Tochuchda's lab instead looked at molecules related with inflammation, finding Activin - A as a candidate drug target.

The research team will now focus on making changes to the harmine and its relatives (harmalogs) to find drug candidates that target only beta cells.

But the new candidate drugs target the neural circuitry of addiction itself.

She is now developing new biomaterials which support cell regrowth, nano - encapsulation for targeted release of drugs and new drug candidates for skin and aging applications.

The other study — Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma — published March 30, shows how drugs targeting PI3K and MAPK could represent promising candidates for glioblastoma therapy.

About 50 code for proteins that appear on the surfaces of these microbial pests and could be drug targets or vaccine candidates.

Triple - negative cancers are so called because they do not express receptors for the hormones estrogen and progesterone, nor for HER2 (human epidermal growth factor 2), and hence patients with these cancers are not candidates for treatment with modern hormonal therapies or the highly effective HER2 - targeted drug Herceptin (trastuzumab).

«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.

Using newly discovered information, the researchers made significant advances in developing a family of drug candidates that target a receptor known as peroxisome proliferator - activated receptors gamma (PPARγ), a key regulator of stem cells controlling bone formation and bone resorption and a master regulator of fat.

The result is a new dual - targeting drug candidate — or, as Griffin describes, «one drug addressing multiple therapeutic indications» — that could treat both diabetes and bone disease.

While the goal of precision medicine is to identify drugs that selectively affect disease - causing biomolecules, the process has typically involved time - consuming and expensive high - throughput screens to test millions of potential drug candidates to identify those few that affect the target of interest.

«Tuberculosis (TB) remains a major global health problem and identifying new drug targets and candidate drugs is a major priority,» said David S. Perlin, Executive Director and Professor at the Public Health Research Institute and Rutgers Regional Biocontainment Laboratory at the International Center for Public Health at Rutgers New Jersey Medical School in Newark.

In this case, both the target and the candidate drug are nucleic acids.

Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.

To narrow down the number of chemical compounds that could be potential drug candidates, scientists utilize computer models that can predict how a particular chemical compound might interact with a biological target of interest — for example, a key protein that might be involved with a disease process.

The development of a project from target protein to potential drug candidate requires the integration of many disciplines and allows scientists to be exposed to techniques far from their own expertise or knowledge.

«Instead of pursuing leads, which is the traditional method, SuFEx click chemistry is about connecting promising drug candidates directly with targets,» says Sharpless.

The new process, called Extensive Combinatorial Refinement (ExCoR), could help improve the development of drug candidates that depend to a great degree on detailed structural analysis to determine how they work against specific disease targets.

Non-exclusive licenses are available for research and sale of products and services across multiple fields including: research tools, kits, reagents; discovery of novel targets for therapeutic intervention; cell lines for discovery and screening of novel drug candidates; GMP production of healthcare products; production of industrial materials such as enzymes, biofuels and chemicals; and synthetic biology.

An alternative approach, most common for anti-infectives, is to use compounds («phenotypic inhibitors») which have already been shown to be active against the target organism in the living pathogenic cell as chemical leads for improvement by Medicinal Chemistry, towards systemically active Candidate Drugs.

This can help identify new molecules likely to inhibit certain therapeutic targets and to lead to novel drug candidates.

While the long - term toxicity and off - target effects of early stage candidate drugs need to be fully characterized, the development of safe and orally active CXCR4 antagonists is a major goal for medicinal chemists.

GigaGen's Surge technology interrogates natural immune systems with unprecedented depth and breadth, radically accelerating target selection, drug candidate identification and pre-clinical assessment of drug efficacy.

It helps us understand the genetic basis of diversity and evolutions in organisms, leading to the insight understanding into how living things evolved through stressed environments to the pathogenesis of pathogens, including identification novel drug targets and development of novel drug candidates.

Our industry - leading technology, invented by GigaGen's co-founders, interrogates immune systems with unprecedented depth and breadth — radically accelerating the selection of drug targets, identification of drug candidates and assessment of pre-clinical drug efficacy.

Being able to go back and forth between the mouse and human genomes so easily has also made it much simpler and quicker to target related human genes that could be candidates for drug development.

NeuroPhage is initially developing drug candidates to treat Alzheimer's and Parkinson's diseases, in which multiple misfolded proteins can exacerbate disease progression, and the Company is also targeting several rare systemic amyloidosis diseases.

Our proprietary antibody discovery technology quickly characterizes every cell in complex immune systems, powering our selection of drug targets, identification of drug candidates and preclinical assessment of efficacy.

Proclara has developed a pipeline of drug candidates that use GAIM to target the common amyloid protein conformation, dissociating and preventing the formation of misfolded protein assemblies, and blocking the cell - to - cell transmission of toxic aggregates.

Quantitative proteomics can also be applied to identify major candidates of proteins targets and mechanism of action by specifically designed experiments using multiple drug / compounds in addition to that / those of interest and probing drug / compound - specific proteome responses to a treatment.

Carmot is applying an innovative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and identify superior drug candidates for challenging therapeutic targets.

Carmot is applying a transformative technology, Chemotype Evolution, to overcome the limitations of conventional discovery technologies and to identify superior drug candidates for challenging therapeutic targets.

Of these, SLC24A4 and CACNA1H are potential candidate genes for BP regulation, and the latter is a drug target for a class of calcium channel blockers.

The availability of a new and improved P. cynomolgi reference genome sequence will enable in - depth studies of this widely used model parasite, including investigations into dormant stages and the selection of new drug targets and vaccine candidates.

Another mouse preclinical screening trial targeted the symptomatic stage (between 9 and 11 months)[44] and a study with a plant extract [99] used 23 - to 24 - month - old mice, but to our knowledge no chemically defined AD drug candidate has been tried at the more pathologically advanced stage used in this study.

Based on basic transcriptional studies of midbrain dopamine neurons, Dr. Kim's lab identified the orphan nuclear receptor Nurr1 as a potential drug target of Parkinson's disease (PD) to develop novel drug candidates for neuroprotective and mechanism - based therapeutics.

Their contributions to the yeast community include physical mapping methods, synthetic lethality screen approaches for identifying cross-species candidate genes as potential cancer drug targets, and a widely used set of vectors and yeast host strains that have been instrumental in work that has led to countless discoveries in recent decades.

His previous work at IDRI has included investigations into the physiology of the M.tuberculosis (Mtb) cell wall, the development of an overexpression library for high throughput target identification, and the development of target based high throughput screens for potential drug candidates against Mtb.

Translational medicine is the integrated application of innovative pharmacology tools, biomarkers, clinical methods, clinical technologies and study designs to improve disease understanding, confidence in human drug targets and increase confidence in drug candidates, understand the therapeutic index in humans, enhance cost - effective decision making in exploratory development and increase phase II success.

Researchers identify a new drug target in leukemia and creation of a candidate drug that hits the target...