Sentences with phrase «duration of response in»

While the duration of response in the velimogene aliplasmid responders was marginally longer than with DTIC / TMZ (P =.066), overall survival was shorter (median, 18.8 months [95 % CI, 16.6 — 21.3 months] vs 24.1 months [95 % CI, 17.1 — 27.9 months]; P =.491).

Patients in cohort A had a median duration of response longer than 1 year (14.7 months); the median duration of response in cohort B was 4.6 months and in cohort C was not estimable.

The first generation of immunotherapies, including immune checkpoint inhibitors and cancer vaccines, have been limited by the proportion of patients who benefit, and by the depth and duration of response in those that do.

Not exact matches

Duration is a measure that helps estimate the amount the price of a bond will rise or fall in response to changes in interest rates.

In its most aggressive stance (a duration of 15 years), the Fund's net asset value could be expected to fluctuate by approximately 15 % in response to a 1 % (100 basis point) change in the general level of interest rateIn its most aggressive stance (a duration of 15 years), the Fund's net asset value could be expected to fluctuate by approximately 15 % in response to a 1 % (100 basis point) change in the general level of interest ratein response to a 1 % (100 basis point) change in the general level of interest ratein the general level of interest rates.

RIAs are eligible to participate in the Program if they represent to Fidelity Investments that they meet the following criteria: (1) RIA is an investment adviser registered and in good standing with the U.S. Securities and Exchange Commission and / or any applicable state securities regulatory authorities or is exempt from such registration; (2) RIA's representatives who provide services to referred clients are appropriately registered / licensed as «Investment Advisers Representatives» in required jurisdictions; (3) RIA charges fee - based, asset - based, or flat - rate investment advisory service fees (which may include hourly fees); (4) RIA will maintain a minimum of $ 350,000,000 in total regulatory assets under management, as reported in response to Item 5 in Part 1A of the RIA's Form ADV, throughout the duration of RIA's participation in the Program; (5) RIA and all associated persons of the RIA who manage client assets or who supervise such associated persons shall at all times be covered through both Errors and Omissions Liability Insurance and Fidelity Bond Coverage; and (6) RIA maintains a minimum of two principals or officers as well as a minimum of five employees.

The Lullaby Trust's Lucy Lyus, Research and Information Manager said in response to the study: «We recommend that women breastfeed their babies, if they can, as breastfeeding for any duration, whether exclusive or in combination with formula feeding, has been found to reduce the chance of Sudden Infant Death Syndrome (SIDS).

Infants in non-Western societies have been found to fuss just as frequently as those in Western societies, but due to the prompt response of caregivers in non-Western societies, the overall cumulative duration of crying is less than what occurs in Western societies.

These results were consistent in the dose - response analyses of breastfeeding duration.

«Patients who respond to immunotherapy tend to continue their responses for long durations, and these lengthier responses are cut off in calculations of median overall survival,» she says.

In addition to helping patients live longer, more patients treated with pembrolizumab responded to treatment and for a longer duration than those treated with chemotherapy; the objective response rate — the percentage of patients whose tumours shrank or disappeared — was almost twice as high with pembrolizumab: 21 % compared to 11 % on chemotherapy.

He noted that such complex responses to differences in dose, timing, and duration of exposure may underlie the inconsistencies in published studies of the relationship between blood levels of manganese in humans and neurobehavioral deficits.

In the HVTN 100 study, the design and schedule of the RV144 vaccine regimen have been altered to try to increase the magnitude and duration of vaccine - elicited immune responses.

While it is not possible to compare antibody levels measured in this trial with those seen in trials of other AMA1 vaccines, based on the relative fold - rise and duration of antibody responses this profile compares favorably with much lower and shorter - lived increases in antibody levels observed in Malian children immunized with AMA1 - C1, an AMA1 vaccine adjuvanted with aluminum hydroxide [19], which provided no measurable protection in a recently reported Phase 2 trial at another site in Mali.

Median duration of response had not been reached in the nivolumab plus ipilimumab arm; it was 31.1 months and 18.2 months for the nivolumab plus placebo arm and ipilimumab - alone arm, respectively.

The safety and reactogenicity of FMP2.1 / AS02A, as well as the magnitude and duration of the antibody response, were evaluated in children naturally exposed to P. falciparum infection.

Additionally, delivering these antibodies with DNA plasmid technology may increase duration of antibody expression in vivo and allowing for simple combination formulations in the absence of a host anti-vector immune response.

Although vaccination induces an inflammatory response during pregnancy, the magnitude and the duration of response is much lower and shorter, respectively, for influenza vaccination than viral infection.27 Like infection, influenza vaccination during pregnancy has been reported to induce a transient increase in the levels of a number of proinflammatory cytokines, including interleukin 6, tumor necrosis factor α, and C - reactive protein.27 - 30 Studies on mice found an association between high interleukin - 6 levels during pregnancy and abnormal behavior and brain structure.19 However, in epidemiological studies, associations between maternal cytokine levels and ASD have been mixed.

Our results also revealed that the inhibition phase of SNr neurons was increased in Q175Het but with no change in either latency or duration of the evoked response.

Different types of training elicit different body response, and in this context, different types can increase testosterone and DHT, but they can also decrease, multiple examples being endurance training, high rep strength training or long duration cardio.

«It is well documented that inappropriate intensity and duration of the stress response may participate in the development of somatic (e.g. hypertension, metabolic and gastrointestinal diseases) and neuropsychiatric disorders (e.g. anxiety, depression, PTSD).

Whether the increase in neural drive at short muscle lengths can transfer from heavy strength training to a fast movement like sprinting is less clear, because of the very velocity - specific (and duration - specific) nature of muscle activation in response to different types of training (Tillin et al. 2012b; 2014).

Our study examined possible differences in the postprandial responses of ghrelin, PYY, and GLP - 1 when identical meals were consumed at two separate sessions of different duration by the same healthy individuals.

On Tuesday, in response to evidence of accelerating yield pressures, as well the recognition that QE2 was much further along than investors widely seem to believe, we substantially cut our bond duration to about 1.5 years in Strategic Total Return.

The duration of a bond fund can tell you roughly how much its value is likely to change in response to a change in interest rates.

Average Effective Duration measures the expected volatility of a bond fund in response to interest rate fluctuations.

Pathogenesis: The severity of cardiopulmonary pathology in dogs is determined by worm numbers, host immune response, duration of infection, and host activity level.

Continuation of Level One skills concentrating on improving responses in the presenses of Distractions and adding complexity to Distance and Duration.

Fear of noises is a normal adaptive response to a real threat, resulting in behavioral and physiological survival responses that drive the dog to seek shelter or otherwise avoid the imminent danger.4 However, when the fearful response to noise is persistent, exaggerated in intensity and duration and results in what appears to be an anxiety attack, this is not normal.

The severity of heartworms in cats is directly dependent upon the number of worms present a cat's body, the duration of the incubation, and the response of the infected cat.

Such anti-viral immune responses often result in the development of sterile immunity and the duration of immunity (DOI) is often lifelong.

Spectators watched, mesmerized, for the full two - hour duration of the live performance at her Australian Centre for Contemporary Art (ACCA) show in 2013, their pleasurable response perhaps triggered by the externalised manifestation of the structures of shame built around defecation since early childhood.

Changes in the duration of the response translate to a big change in the adjusted trend since 1997.

If you have been involved in the struggle to expose and halt climate engineering for any duration, you have certainly heard the «our government would not do this to us» programmed response of total denial.

it is found that global temperature trends since 1998 are consistent with internal variability overlying the forced trends seen in climate model projections (Easterling and Wehner, 2009; Mitchell et al., 2012b); see also Figure 1.1, where differences between the observed and multimodel response of comparable duration occurred earlier.

Although anchoring biases, difficulties in predicting the duration and degree of a crime victim's future emotional response, and poorly written jury instructions challenge juries, each of these impediments can be counteracted through thoughtful and conscientious systemic responses.

In response, Facebook promises to restrict the amount and duration of data it accesses through Messenger's call and text history feature, which is emphasized is completely opt - iIn response, Facebook promises to restrict the amount and duration of data it accesses through Messenger's call and text history feature, which is emphasized is completely opt - inin.

[ANONYMOUS LISTSERVE RESPONSE]: «Before I'd support the a plan that has a 3 - year - old having three - week separations from parents, I'd want to know the basis for determining that this kid's capabilities, separation issues, ability to participate in telephone or web visits, etc., exceed the capabilities of most three - year - olds to the point that a separation of this duration isn't a problem.

The extent to which stressful events have lasting adverse effects is determined in part by the individual's biological response (mediated by both genetic predispositions and the availability of supportive relationships that help moderate the stress response), and in part by the duration, intensity, timing, and context of the stressful experience.

No dose - response studies have been reported previously, and there is poor understanding of the duration of treatment necessary to produce an effect.2 - 4 Randomised controlled trials have investigated a range of folate doses from 200 to 5,000 mcg / day with varying findings.3 - 4 Folic acid and vitamin B12 are unlikely to be an effective short - term intervention for preventing depression in doses that can be recommended as a dietary supplement.

The relations between independent predictor variables (measures of immunological and psychological function at entry to the trial, age of onset, and duration of illness) and dependent dichotomous outcome variables (self rated global outcome; presence or absence of caseness on the general health questionnaire at follow up; reduced or normal delayed responses to hypersensitivity skin test) were examined in separate logistic regression analyses.

In response, the Close the Gap Campaign calls on the Australian Government to introduce and pass legislation to formalise a process for national monitoring and reporting on efforts to close the gap in accordance with benchmarks and targets for the duration of the national efforIn response, the Close the Gap Campaign calls on the Australian Government to introduce and pass legislation to formalise a process for national monitoring and reporting on efforts to close the gap in accordance with benchmarks and targets for the duration of the national efforin accordance with benchmarks and targets for the duration of the national effort.

A negative dose — response relationship was observed between the T / S ratio and tobacco exposure duration: the longer the duration of maternal smoking in pregnancy, the shorter the child's telomere length.

The term emotion dysregulation has been applied to problems with the intensity, frequency and duration of emotional responses, as well difficulties modulating emotional experiences in effective and adaptive ways (Bloch, Moran & Kring, 2010).

If the response from your property listing on RentalAds.com does result in 3 or more inquiries (phone plus email) during the first 30 days under the terms and conditions listed below, RentalAds.com will extend your listing duration for an equal amount of time without charge.