Sentences with phrase «during cell expansion»

Not exact matches

They found the CD4 + T - cells were globally expanded and activated during chronic ischemic heart failure, and that there was an expansion of memory T - cells in the spleen.

Nine patients were treated with tocilizumab, an immunosuppressant drug that blocks the effects of the inflammatory cytokine IL - 6, which have been found to spike during the most robust phase of the engineered cells» expansion in the body.

The authors uncover the cellular and molecular mechanisms, as well as the gene network regulated by Sox9 during the early steps of skin tumor initiation and demonstrates that Sox9 controls the long term maintenance and expansion of oncogene expressing cells by promoting self - renewing division and inhibiting differentiation.

Perhaps during normal inflorescence development, SMs poised to become bristles accumulate higher levels of BR, resulting in local increased cell division and expansion, loss of boundary identity genes, and repression of the SM identity program.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

For instance, during emergency care, allogeneic therapy is usually the only relevant option due to the time constraints of autologous cell expansion.

During tumor development, rapid expansion of cancer cells creates a hypoxic microenvironment that is followed by periods of reoxygenation to promote tumor progression.

A new study demonstrates how a three - dimensional culture substrate can help to maintain the number of primitive stem cells present during the expansion...

Traditionally, the growth rates of hESC colonies have been manually counted from single cell suspensions as doubling time during the exponential growth phase [13] or as an expansion of the area of a single colony from microscopic images [14].

Beyond the expansion of the collection of barcoded cell lines for testing larger panels of compounds, next steps will include determining whether PRISM can be used to study the complex interactions between different cell types found within tumors, or to study tumor evolution during cancer development or after cancer treatment.

DIC images of endothelial progenitor cells (EPCs) during in vitro expansion (A) and differentiation (B).

Results: During in vitro culture period, the percentages and absolute numbers of T cells expressing the CARs containing a hinge domain continuously increased, mainly through the promotion of CD4 + CAR T cell expansion, regardless of the single - chain variable fragment (scFv).

The «Functional Genomics in Embryonic Stem Cells» consortium comprising 20 research groups (acronym FunGenES; http://www.fungenes.org) has analyzed the transcriptome of ES cells under a series of diverse stimuli during growth expansion and differentiaCells» consortium comprising 20 research groups (acronym FunGenES; http://www.fungenes.org) has analyzed the transcriptome of ES cells under a series of diverse stimuli during growth expansion and differentiacells under a series of diverse stimuli during growth expansion and differentiation.