4.4 Technologies for Generation of TCRL Antibodies 4.4.1 TandAb 4.4.2 BiTE 4.4.3 E-Alpha
Phage Display 4.4.4 HuTARG Protein Engineering 4.4.5 MAR & TriTE 4.4.6 TCRL Antibodies 4.4.7 TCRm Antibodies 4.4.8 Ylanthia Fab library 4.4.9 TCRL ADCs
Obtained as a Fab by selection against gp120 IIIB of an antibody
phage display library prepared from bone marrow of a asymptomatic HIV - 1 seropositive donor.
Together with CSL we embarked on a collaborative project aiming to identify novel antibodies to target melanoma cells using
phage display technology.
Around the same time that transgenic mice began to be used to produce human antibodies, scientists also started employing a genomic technology called
phage display to build massive libraries of human antibody genes that could be screened quickly.»
Liu J, Lubelski D, Schonberg D, Wu Q, Hale J, Flavahan W, Man J, Hjelmeland A, Yu JS, Lathia J, Mulkearns - Hubert E, Rich JN,
Phage Display Discovery of Novel Molecular Targets in Glioblastoma Initiating Cells.
He was a postdoctoral scientist at Applied Molecular Evolution, where he produced and screened random peptide
phage display libraries with soluble empty mouse CD1 (mCD1) to identify a peptide - binding motif for MHC Class I like receptors.
In this proposal we set out to utilize our canine - derived scFv
phage display platform technology to isolate canine antibody fragments that bind and neutralize Vascular Endothelial Growth Factor (VEGF).
Not exact matches
Another student who was using
phage -
display technology to identify new molecular markers in ovarian cancer attended a clinic in gynecologic oncology once a week throughout her dissertation research.
Human Antibodies From V - Gene Libraries
Displayed on
Phage», Journal of Molecular Biology, 222: 581 - 597, 1991.
Utilizing multiple discovery platforms including; forward genetic screens (shRNA),
phage - based peptide
display, and ChIP - Seq to identify novel molecular interactions that occur during the development of IBC and metastatic breast cancer