«In this study, we used a combination of synthetic polymers and
ECM proteins to fabricate biocompatible JetValves that are hemodynamically competent upon implantation and support cell migration and re-population in vitro.
Background: * Pulmonary fibrosis is a chronic lung disease, characterized by pathological accumulation of
ECM proteins, which results in hardening of the lung and thus difficulties to breathe.
Following up on this observation, they discovered that injection of IL - 33 into mice caused
ECM proteins to build up in the liver, whereas mice that were genetically modified to lack IL - 33 were largely protected from fibrosis.
Not exact matches
But little is known about how ionizing radiation affects the extracellular matrix (
ECM), a patchwork of
proteins and other biomolecules that surrounds cells and plays a vital role in their shape, movement and signaling functions.
Once thought to be a simple cellular shock absorber,
ECM is now understood to contain powerful
proteins that can reawaken the body's latent ability to regenerate tissue.
«The information we have gained about the dynamic changes in
ECM composition and its interactions with various secreted growth factor
proteins enables us to develop new hypotheses for the activation of stem cells in the lung,» explains Dr. Herbert Schiller, first author of the study.
Due to its diverse physiological functions, the
ECM has to be more than a homogeneous mass of
proteins and carbohydrates.
'' «Figure 4: Effect of telomerase deficiency on extracellular matrix (
ECM)
protein molecules during in vitro osteoblast differentiation of BMSCs.
Similarly, metazoan extracellular matrix (
ECM)
proteins use domains that evolved on the holozoan stem.
In this study we report a number of
proteins that could be validated as potential biomarkers of
ECM.