EMBRYO EDIT Researchers in China and Texas have used CRISPR / Cas9 to repair disease - causing mutations in viable human embryos.
Not exact matches
In February, the United Kingdom approved using the method on human
embryos at the Francis Crick Institute in London, but only within a narrow capacity:
Researchers can
edit genes in non-viable human
embryos for a limited period and only to study developmental biology related to in vitro fertilization.
Nearly five years after the gene -
editing tool debuted,
researchers for the first time have used it to alter genes in viable human
embryos.
Now
researchers have found how RNA
editing helps turn overheated male
embryos into females (SN Online: 6/14/17).
In July,
researchers announced they had successfully
edited the genome of viable human
embryos with CRISPR; the technique allowed them to fix a disease - causing mutation in the
embryos» DNA (though some are now skeptical of the
researchers» results).
A Swedish scientist is gene
editing healthy human
embryos, and he is probably not alone,
researchers say.
Researchers in other countries have
edited human
embryos to learn more about early human development or to answer other basic research questions (SN: 4/15/17, p. 16).
EDITS UNDER WAY
Researchers in Sweden have begun
editing genes in viable early human
embryos (four - cell stage, shown).
Chinese
researchers have twice reported
editing genes in human
embryos that are unable to develop into a baby (SN Online: 4/6/16; SN Online: 4/23/15).
In addition, the
researchers discovered a technical advance that may limit the production of patchwork
embryos that aren't fully
edited.
In the latest experiments the Mitalipov group focused on snipping out the mutated gene in heterozygous cells — a situation in which there was still a «good» nonmutated copy available for the natural cellular repair systems in the
embryo to use as a template for repair after the
researchers edited out the problematic one.
George Daley, a stem cell
researcher and dean of Harvard Medical School agrees: «This paper establishes that we can do
embryo gene
editing.
In line with the views of most biomedical
researchers, lawmakers struck a note of caution about the implications of new gene
editing techniques that make heritable changes to human
embryos.
But in September last year the team announced it had applied to conduct genome
editing on these
embryos — five months after
researchers in China had reported experiments applying CRISPR — Cas9 genome
editing to non-viable human
embryos, which sparked a debate about how or whether to draw the line on gene -
editing in human
embryos.
Amid rumors that precision gene -
editing techniques have been used to modify the DNA of human
embryos,
researchers have called for a moratorium on the use of the technology in reproductive cells.
Chinese
researchers report this week that they have used the CRISPR gene -
editing technique to modify the genome of a human
embryo in an effort to make it resistant to HIV infection.
Researchers at Oregon Health and Science University captured the development of human
embryos in images as part of their work using a gene -
editing tool.
Earlier this year, developmental biologist Robin Lovell - Badge, also at the Francis Crick Institute, told Nature that he thought that the carefully considered UK approval might embolden other
researchers who are interested in pursuing
embryo -
editing research.
Researchers in China have reported
editing the genes of human
embryos to try to make them resistant to HIV infection.
Researchers in China have
edited the genes of human
embryos to make cells resistant to HIV infection.
Using the gene -
editing tool known as CRISPR / Cas9, the
researchers have successfully
edited disease - causing mutations out of viable human
embryos.
A week later, a network of stem - cell
researchers, bioethicists and policy experts called the Hinxton Group, said that after meetings in Manchester, UK, they had concluded that research involving genome
editing in human
embryos has «tremendous value to basic research».
Since Chinese
researchers announced the first gene
editing of a human
embryo 2 years ago, many expected that similar work in the United States was inevitable.
Some
researchers are pleased with the report, saying it is consistent with previous conclusions that safely altering the DNA of human eggs, sperm, or early
embryos — known as germline
editing — to create a baby could be possible eventually.
Last month, a team of Chinese
researchers reported that, in a first - of - its - kind event, they had
edited the genomes of human
embryos.
By growing primordial germ cells in culture
researchers can make genome
edits sequentially without being restricted by the breeding cycle of living birds, and the cultured cells will contribute to the germ line when injected into new
embryos.
Another team of Chinese
researchers, in Guangzhou, have already done an experiment
editing the genes of (non-viable) human
embryos; in December, a number of the world's leading
researchers met in Washington, D.C. to discuss the ethics behind using CRISPR on humans.