Using transcription and DNA binding to identify functional DNA,
the ENCODE consortium estimated that as much as 80 % of the human genome might be functional [30].
VOCATION AVOCATION «Cat herder in chief» of
the ENCODE consortium of 400 geneticists from around the world
Siepel's team began by sorting
ENCODE consortium data based on combinations of biochemical markers that indicate the type of activity at each position.
Not exact matches
Although genes make up only 3 percent of the
ENCODE sequence, the
consortium found that 93 percent of the sequence is transcribed.
Nevertheless, «before
ENCODE, I think a lot of people were skeptical of how real intergenic activity was,» says bioinformatician and
consortium member Mark Gerstein of Yale University.
More than 200 scientists from dozens of institutions contributed to this effort, which is collectively part of the
ENCODE genomics
consortium.
Renowned molecular biologist and scholar of science and religion, Denis Alexander, described recent advances in developmental biology, genomics, epigenetics and behavioral genetics, including the flurry of publications describing results from the Encyclopedia of DNA Elements (
ENCODE)
consortium, and discussed their implications for notions of human freedom and responsibility.
«Massive research
consortia, like the
ENCODE Project, have provided the scientific community with a trove of information about genomic function over the last few years,» says Siepel.
-LSB-...] An interesting blog post on data release by
consortia including
ENCODE.