However,
the ERG response from the degenerating cones declines with age and is non-recordable in the mature CD - affected dog.
ERG response amplitudes to full field light stimulation were recorded at approximately P100 in RCS rats injected with hNPCctx — GDNF (n = 9), hNPCctx (n = 21) or medium alone (n = 3) into the subretinal space.
(A) Representative
ERG response of the induced and control eye recorded from the same animal.
When transplanted to the mouse retina, human ES cells directed to a retinal lineage partially restore light - elicited
ERG responses [5].
ERG responses of control and induced eyes were similar in sensitivity and time course (Figure 6A).
(A and B)
ERG responses of control (WT) and induced eyes (IE) are similar.
At approximately P100, eyes receiving either hNPCctx (n = 21) or hNPCctx - GDNF (n = 9) injections retained robust
ERG responses (Figure 2).
Both cone and rod mediated
ERG responses are highly abnormal, probably due to a combination of responses from rods and possibly cones with very reduced sensitivity [58].
In RCD3 affected dogs normal rod - mediated
ERG responses fail to develop, photoreceptor outer segments do not reach maturity and rod cells are lost by apoptosis [5].
Not exact matches
When transplanted to the subretinal space of mice lacking functional photoreceptors, human embryonic stem cells directed toward a retinal lineage integrate into the outer nuclear layer, express photoreceptor markers, and restore a light
response as determined by the electroretinogram (
ERG)[5].
The other example is the Emergency
Response Guidebook (
ERG), a collaborative publication from the governments of the United States, Canada, Mexico, and Argentina, for which my company publishes an ebook version.
With the release of the Emergency
Response Guidebook 2016, the National Institutes of Health has released a free
ERG 2016 app for Android and iOS.
CRDs have ophthalmoscopic changes that are very similar to those of PRA and detailed
ERG studies that measure both cone and rod - specific
responses are required to distinguish between the two types of condition.
ERG amplitudes are further decreased at Stage 3 (third row), especially rod - mediated
responses, and may not even be recordable in some affected dogs (flat lines in fourth row).