Sentences with phrase «erk phosphorylation»
Trametinib inhibits RAS - mutant MLL - rearranged acute lymphoblastic leukemia at specific niche sites and reduces ERK phosphorylation in vivo
http://www.haematologica.org/
We observed that Erk phosphorylation was modestly enhanced in Cbl - b − / − CD8 + T cells when compared with wild type (WT) T cells but was greatly enhanced in DGKζ − / − and DKO CD8 + T cells when compared either with Cbl - b − / − or WT CD8 + T cells (Fig. 1A).
Effective inhibition of SDF -1-driven ERK phosphorylation and inhibition of SDF -1-mediated in vitro proliferation were observed.
Not exact matches
Western blot analyses with phospho - specific antibodies suggested that stretching induces phosphorylation of ERK of the MAP kinase pathway, but did not induce phosphorylation of phosphatidylinositol 3 - kinase.
The authors discovered that FGF2 treatment forced a high percentage of astrocytic cell - cycle re-entry via FGF receptor - induced phosphorylation of ERK and mediated the generation of self - renewing Nestin - expressing NSCs.
To define the signaling changes resulting from each genotype, we isolated naive CD8 + T cells from mice deficient in DGKζ, Cbl - b, or both in DKO; stimulated the cells through their TCRs; and evaluated phosphorylation of Erk and phosphorylation and degradation of IκBα.
Acute Ethanol Increases IGF - I - Induced Phosphorylation of ERKs by Enhancing Recruitment of p52 - Shc to the Grb2 / Shc Complex.
However, the ActD - induced phosphorylation (Ser15) of p53 was not inhibited by the inhibitors of p38, JNKs and ERKs in the current study, indicating that the phosphorylation (Ser15) of p53 was independent of these three MAP kinases.
The expression and phosphorylation (Ser15) of p53 is independent of JNKs, ERKs, and p38.
Furthermore, anti-CD3 mAb induced phosphorylation of ERK, phospholipase C γ (PLC - γ), and SLP76, all were unaltered in Gasp - deficient DP thymocytes (Fig. 5F).
In particular, our results demonstrate that LA increases reactive oxygen species levels, stimulates the phosphorylation of EGFR, ERK and c - Jun and induces the expression of c - fos.