Sentences with phrase «erk5 signaling axis»

The binding of a BRAF mutation to the ER stress gatekeeper GRP78 is a new and unexpected molecular interaction driving resistance, and establishes a new signaling axis that has multiple drug targets, Dr. Amaravadi said.

«Our work shows that the PKCepsilon / Nanog / Bmi1 signaling axis is essential to promote head and neck cancer,» Pan says.

«This study defines a signaling axis that is essential for head and neck cancer progression, and our findings show that this axis may be disrupted at three key steps,» says principal investigator Quintin Pan, PhD, associate professor of otolaryngology at the OSUCCC — James.

Inhibition of cell migration and invasion of enzalutamide - resistant prostate cancer cells was effected by niclosamide through its effects on the androgen receptor (AR)- STAT3 signaling axis [40].

Ongoing projects aim to define the involvement of these two signalling axes in cancer and to investigate whether the endocytic function of Numb is relevant to its tumour suppressor function.

Not exact matches

Arrows indicate signal intensities that were greater than the abundance values on the y axis.

The radio and x-ray signals come from the jet, which at first would have beamed them too narrowly along its axis to be seen from Earth.

The strength of the signal also varied over hours, weeks and months, because of the water vapor plumes rotating in and out of Herschel's views as the object spun on its axis.

Whereas most chiroptical effects result from a response of bound electrons, photoionization can produce much stronger chiral signals that manifest as asymmetries in the angular distribution of the photoelectrons along the light - propagation axis.

The rate at which each cell sent electrical signals was proportional to a given face's coordinate position along an axis.

But now mission controllers must «focus on new classes of science,» the most exciting of which is using Spirit's radio signal to track the motion of Mars both in its orbit and in its spin on its axis.

The result of this collision was what is known as the Variscan orogeny, the raising of a mountain range along the North - South axis, which left the rocks with a secondary magnetic signal, adapted to the new magnetic field of the Earth.

With these tools in hand, they determined that in Hofstenia, as in planarians, Wnt signaling controls regeneration along the anterior - posterior (head - tail) axis and Bmp - Admp signaling controls regeneration along the dorsal - ventral (back - belly) axis.

Diverse signaling pathways through the SDF - 1 / CXCR4 chemokine axis in prostate cancer cell lines leads to altered patterns of cytokine secretion and angiogenesis.

Central hypothalamic insulin signaling interfered with negative feedback to the hypothalamus - pituitary - adrenal (HPA) axis in stressed male mice (151), which potentially explains high comorbidity rates of mental and metabolic disorders (see section V.P).

The co-incidence of these 2 pathologies occurs also in humans suggesting a common pathological mechanism moving across the gut - joint axis, with TNF signals acting on specific cell types directing pathogenesis at two different locations.

Prof. George P Chrousos is internationally recognized for his research on the glucocorticoid signaling system of the cell, on the diseases of the hypothalamic - pituitary - adrenal axis, and on the physiological and molecular mechanisms of stress.

A complex set of interactions between morphogens and their corresponding signalling pathways contributes to organizing limb growth along the dorsal - ventral, anterior - posterior and proximal - distal axes.

Joint NOD2 / RIPK2 signaling regulates IL - 17 axis and contributes to the development of experimental arthritis

For instance, the role of LIF - gp130 - Stat3 axis in promoting ES cell proliferation is particularly well - defined [1], [3], and BMP - induced differentiation signals are inhibited by a Nanog - Smad1 protein complex [4]; crosstalk between these pathways has also been reported [5].

Interaction between the human host and its's microbiome is mediated via several axes of communication including the immune system, signalling and direct metabolic cross-talk that physiologically connect the gut with the brain, muscle and liver.

Here, Dr. Tam presents data characterizing the intracellular signaling pathway associated with the RANK — RANKL axis, as well as the effect in dendritic cells, antigen - specific T cells, cytokines, and chemokine profiles after in vivo treatment with blocking PD - L1 and T cell - depleting antibodies in a melanoma cancer model.

Calcium ions also allow neurons to signal one another, which ties in to the gut - brain - skin axis.

In liver, FGF21 inhibits the GH signaling pathway... Thus, FGF21 - mediated repression of the GH / IGF -1 axis provides a mechanism for blocking growth and conserving energy under starvation conditions.

First, signals from the HPAT axis say, «Stop!»

The HPA axis is composed of the two regulatory control centers in the brain: the hypothalamus and pituitary gland, which secrete stimulatory neurotransmitters that signal the adrenal glands to produce cortisol, the body's main anti-stress hormone.

The Hypothalamic - Pituitary - Adrenal (HPA) axis is a feedback loop by which signals from the brain trigger the release of hormones, such as cortisol, needed to respond to stress.

The HPA axis relies on a series of hormonal signals to keep the sympathetic nervous system — the «gas pedal» — pressed down.

The term «microbiota - gut - brain axis» is used to describe the complex bidirectional signaling that occurs between the GI tract and the nervous system, and emphasizes the newly recognized role of intestinal microbes in these interactions.

Fyodor's Carousel was animated by a centripetal acceleration and ran off the audience's pedal - power; it rotated on its own axis and the force driving it signalled the human intimacy at its heart.

The first thing that seers itself into your line of vision are the 12 panel paintings by Rochelle Feinstein which began in 2008 to mark American - led invasions of the Middle East and the halftone dots forming the outline of globes that seem to be turning on a wobbly axis embody the various definitions of the word «hotspots» as a Wi - Fi signal location, a jumping night spot, central hotbed of activity, etc..

An emerging body of literature24, 25 shows that a subgroup of chronically aggressive children exhibit marked difficulty processing social cues that signal the need to inhibit aggressive impulses.26 These findings have been attributed to reduced responding in specific neural architecture associated with stress responses and HPA axis regulation.