Not exact matches
In the first, surgeons will inject
ES -
cell - derived neuronal -
precursor cells into the brains of individuals with Parkinson's disease.
Zhou's team will coax
ES cells to develop into
precursors to neurons, and will then inject them into the striatum, a central region of the brain implicated in the disease.
Jeanne Loring, a stem -
cell biologist at the Scripps Research Institute in La Jolla, California, who is also planning stem -
cell trials for Parkinson's, is concerned that the Australian and Chinese trials use neural
precursors and not
ES -
cell - derived
cells that have fully committed to becoming dopamine - producing
cells.
The first step of our program is to apply the previously established lab - culture conditions that first commit human
ES (hES) and iPS
cells into retinal
precursors.
In a study published earlier this year, the same Belmonte and Gage lab team demonstrated that a few
ES cells in a culture dish tended to lose stemness and evolve into muscle
cell precursors, most likely goaded by a muscle differentiation factor known as BMP.