Sentences with phrase «early clinical evidence»

«Biologic models and early clinical evidence suggest that these fusions lead to oncogene addiction regardless of tissue of origin and, in aggregate, may be implicated in up to 1 % of all solid tumors,» wrote the study authors, led by Alexander Drilon, MD, of Memorial Sloan Kettering Cancer Center in New York.

Early clinical evidence with the PEC - Encap product supports the potential of the replacement cell therapy approach.

Not exact matches

Now a University of Colorado Cancer Center study published online ahead of print in the journal Oncogene offers compelling evidence explaining this failure and offering a possible strategy for the use of retinoic acid or other retinoids against some breast cancers: Because early clinical trials are often offered to patients who have already tried other more established therapies, breast cancer cells may have been pushed past an important tipping point that offers retinoic acid resistance.

«The Prostate Health Index is a significant addition to our comprehensive menu of advanced clinical evidence ‐ based blood tests that aid in early cancer detection.»

Dr. Persaud said that when Duchesnay approached the FDA in the early 2000s to approve pyridoxine - doxylamine, the regulatory agency said it needed evidence from a clinical trial.

The findings provide the highest level of evidence supporting expert - derived clinical practice guidelines which have recommended Oncotype DX in patients with early stage ER - positive breast cancer.

«The compelling results seen in this global study provide unequivocal evidence supporting the clinical utility of Oncotype DX to risk - stratify patients with early stage breast cancer, and indicate that the findings are generalizable to everyday clinical practice,» said lead author Joseph A. Sparano, MD, vice-chairman of medical oncology at Montefiore Einstein Center for Cancer Care, and professor of medicine and of obstetrics, gynecology, women's health at Albert Einstein College of Medicine.

But the idea of single - subject research didn't really make the leap to medicine of the body until the early 1980s when Gordon Guyatt, a Canadian physician now known as a founder of evidence - based medicine, began working in an interdisciplinary department at McMaster University in Ontario, with psychologists, biostatisticians, ethicists and clinical epidemiologists all working together.

The impetus for the plan is evidence from recent clinical trials showing that treating people with HIV earlier not only reduces the likelihood of disease progression but also lowers the chances that they will infect others.

«Our present study shows examination of the gene expression profiles at the very early age of initial clinical detection reveals both strong evidence of early biological processes in ASD and abnormal signals with the potential to serve as an early, practical biomarker of risk for the disorder in general pediatric settings.»

While the study did not support earlier findings that sitagliptin was an effective treatment for NAFLD, Loomba said it provided new evidence that clinical trials with patients at higher risk of diabetes do not necessarily need a liver biopsy to be efficiently screened for potential therapeutic agents.

Contracted through the bite of an infected mosquito or through sexual or other modes of transmission, Zika virus (ZIKV) infection can be prenatally passed from mother to fetus.1 The virus was first identified in the region of the Americas in early 2015, when local transmission was reported in Brazil.2 Six months later, a notable increase in the number of infants with congenital microcephaly was observed in northeast Brazil.3, 4 Clinical, epidemiologic, and laboratory evidence led investigators to conclude that intrauterine ZIKV infection was a cause of microcephaly and serious brain anomalies.5 - 7 However, as with other newly recognized teratogens, these features likely represent a portion of a broader spectrum.

However, J. Chad Teeters, MD, a cardiologist and assistant professor of clinical medicine at the University of Rochester Medical Center, in New York, says that the study findings are the latest evidence that homocysteine is of little use as an early warning sign of heart attacks or heart disease.

-LSB-...] There is now substantial empirical and clinical evidence to indicate that many of these deleterious changes are directly related to the predominately cereal - based diets of these early farmers.

According to a 1987 study by Nair et al. in the American Journal of Clinical Nutrition, the earliest evidence of a lowered metabolic rate in response to fasting occurs after 60 hours (with an 8 % drop in resting metabolic rate).

Circulating testosterone levels decline with increasing age but do not appear to be significantly affected by the menopausal transition.8 As early as the 1940s, testosterone was reported not only to alleviate menopausal symptoms but also to restore libido.9 In recent years, evidence has accumulated supporting the hypothesis that the decline in endogenous testosterone levels is associated with menopausal symptoms, including decreased libido, worse moods, and poorer quality of life.10 Clinical trials have demonstrated that exogenous androgens in conjunction with estrogens can ameliorate symptoms affecting sexual function and general well - being.11, 12 In addition, studies have found beneficial effects of androgen therapy on bone mineral density.13 - 15

Clinical signs may be vague in the early stage of GBM development: inappetence or evidence of distress after eating.

However there also is new clinical and research evidence that early spaying is not advisable.

Synthetic colloids were previously used early and commonly in septic patients Recent evidence in human patients and experimental + / - clinical animal studies suggests negative risk - benefit assessment.

«The sum of the evidence against saturated fat over the past half - century amounts to this: the early trials condemning saturated fat were unsound; the epidemiological data showed no negative association; saturated fat's effect on LDL - cholesterol (when properly measured in subfractions) is neutral; and a significant body of clinical trials over the past decade has demonstrated the absence of any negative effect of saturated fat on heart disease, obesity, or diabetes.

The further steps in the new Pre-Action Protocol for the Resolution of Clinical Disputes are likely to increase the front - loading of costs as parties make more and earlier use of expert evidence.

In clinical negligence, Pt 36 will play a more tactical role in the defence toolkit and there will be a «raft» of cases clarifying its redraft; the pre-action protocol for the resolution of clinical disputes is likely to increase the frontloading of costs as parties make «more and earlier use of expert evidence».

Training and Development Clinical Correlations; X-ray Objective Findings, Minneapolis, MN 2009; Expert Medical Deposition, Minneapolis, MN 2009; Current Understanding of Pain Assessment, Minneapolis, MN, 2008; Professional Boundaries, Minneapolis, MN 2008; Case Study Utilizing MRI for Joint and Low Back Pain, Minneapolis, MN 2008; Importance of Identifying the Pain Generator Early, Minneapolis, MN 2008; MRI and Medical Evidence of Soft Tissue Injury, Minneapolis, MN 2008; Ethics and Guidelines for Patients, Minneapolis, MN 2008; Localizing / Identifying Injuries in Collision and Non-Collision cases, St. Paul, MN 2006; Developing Care Plans for Acute and Chronic Cases, St. Paul, MN 2006; Record Keeping in Acute and Chronic Cases, St. Paul, MN 2006; X-Ray Interpretation in Collision Related Cases, St. Paul, MN 2006; Record Keeping and Documentation in Auto Collision Cases, St. Louis Park, MN 2005; Research Comparing Dummies vs. Live People in Auto Collisions, St. Louis Park, MN 2005; Injuries from Low Impact Collisions and Neurological Injuries, St. Louis Park, MN 2005; Permanent Post Concussion Syndrome, Minneapolis, MN 2004; Trauma and Non-Trauma Induced Conditions of the Spinal Cord, Minneapolis, MN 2004; HIPPA Training, Edina, MN 2003; Coding and Billing Training, Edina, MN 2003; Current Topics in Chiropractic Research, Golden Valley, MN 2002; Activator Methods, Bloomington, MN 2001; Foundations of Physical Activity, Bloomington, MN 2001; Effect of Diet and Exercise on Health and Wellness, Bloomington, MN 2000; Occupational Health & Industrial Chiropractic, Bloomington, MN 2000

Judge Hand bases his decision in part on clinical data outlining the dangers of pregnancy and the usefulness of contraception, saying that, if this evidence had been available to Congress earlier, Congress would never have defined birth control as obscene.

There is now ample evidence from the preclinical and clinical fields that early life trauma has both dramatic and long - lasting effects on neurobiological systems and functions that are involved in different forms of psychopathology as well as on health in general.

The presentation addresses the empirical foundations of schema theory by shedding light on the role of early maladaptive schemas in depression etiology and reviews the clinical evidence of schema therapy as a possible treatment option for (chronic) depression: Limited evidence suggests that ST by targeting self - referential cognitive schemas (EMS) which mediate the effects of early life adversity on vulnerability towards and maintenance of depressive disorders in the sense of distal risk factors could be an effective treatment for depression and a feasible alternative to CBT (Brewin et al. 2009; Carter et al. 2013; Malogiannis et al. 2014; Renner et al. 2016).

«Thorough, clear, judicious, and thoughtful examination of research and clinical evidence regarding early child development.»

Conclusion Our study provides evidence that a significant proportion of outpatients experience depression or depressive symptoms, highlighting the importance of developing effective management strategies for the early identification and treatment of these conditions among outpatients in clinical practice.

Currently, there is limited evidence about the effectiveness of clinical interventions for young people who engage in self - harm, although there has been much work in the area since the earliest systematic review [18].

Since CU traits have shown a certain stability from early childhood to adolescence [32, 34], and given the evidence of severe outcome associations, more research is needed in large community samples from different cultures to identify the clinical benefits of identifying the ODD plus CU traits subgroup, especially early in life, given the preventive potential of early identification.

There is evidence that the co-occurrence of internalizing and externalizing problems may operate in a synergistic fashion in clinical samples (Riggs et al. 1995) and that internalizing problems more consistently predict SU later in adolescence (Sung et al. 2004) and in early adulthood (Hussong et al. 2011).