Sentences with phrase «early in the disease»

My hunch is that these emotions usually come early in the disease, during the first struggles with the reality of chronic illness.

Chief executive Neil Hunt said: «This blatant cost - cutting will rob people of priceless time early in the disease and later clinicians will have no choice but to use dangerous sedatives that increase the risk of heart disease and stroke.»

A drug that ramps up the inflammatory response could help early in the disease, but applying a boost later might make things worse, suggests Yadong Huang, a U.C.S.F. neuroscientist who studies ApoE but was not part of the Nature study.

Certain symptoms that appear early in the disease, such as rigidity, can interfere with a patient's ability to write or sketch.

An accurate diagnosis can be difficult early in the disease, says immunologist Paul Arnaboldi of New York Medical College in Valhalla, who was not involved in the study.

Next, Ubogu and his team looked at an animal model of AIDP where they were able to block CD11b early in the disease process.

«For many years, the rheumatology and dermatology communities have been trying to understand which patients with psoriasis go on to develop psoriatic arthritis and how we might detect it earlier in the disease course,» explained senior investigator Cheryl Barnabe, MD, MSc, of the McCaig Institute for Bone and Joint Health and the O'Brien Institute for Public Health, Cumming School of Medicine, at the University of Calgary, Alberta, Canada.

Diabetes researchers are considering various replacements for insulin injections: Transplanting new pancreatic islet cells that make insulin, coaxing the patient's own islets to regenerate, or treating diabetics early in the disease with immune - suppressing therapies to prevent their body from destroying the rest of their pancreatic islets.

Lou Gehrig's disease, also known as amyotrophic lateral sclerosis, or ALS, might damage muscle - controlling nerve cells in the brain earlier in the disease process than previously known, according to research from the Cedars - Sinai Board of Governors Regenerative Medicine Institute.

The authors suggest that while it is not certain that this particular strategy or drug could be effective, it is possible that either not enough drug was administered or that the drug needs to be administered earlier in the disease course.

Second, neuroimaging and basic science research aimed at identifying potential treatments is shifting the field's focus to earlier in the disease trajectory, driven by the belief that interventions stand the greatest chance in people who have not become too impaired.

Detection of dementia at the earliest stages has become a worldwide priority, because drug treatments, prevention strategies and other interventions will likely be more effective very early in the disease process, before extensive brain damage has occurred.

«Interrupting Parkinson's disease: Treating with antioxidants early in disease process may halt degeneration and improve neuronal function.»

«Those MS patients who have cerebral microbleeds are subject to developing more physical and cognitive disabilities earlier in their disease, and therefore monitoring them more closely might be appropriate,» Zivadinov noted.

Intervening with an antioxidant early in the disease process may break the degenerative cycle and improve neuron function in PD, the study showed.

Early in the disease, people can manage their symptoms by pointing a hairdryer at their eyes at arm's length to accelerate drying the corneal surface.

To troubleshoot potential glitches, they're trying many β amyloid — targeting strategies, from preventing its buildup and removing existing clumps to giving the drugs earlier in the disease.

New research from scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) published in the journal Circulation, may lead to a new approach to help treat heart failure early in the disease.

If we are going to develop protective therapies for Alzheimer's, we have to aim to do it earlier in the disease process.

Looking for immune abnormalities throughout the lifespan of the mice, the group found that most immune system components stayed the same in number, but a type of brain - resident immune cells called microglia that are known first responders to infection begin to divide and change early in the disease.

These findings demonstrate that the vascular effects of sleep apnea are reversible if treated early in the disease process, suggesting that we might be able to mitigate the long - term risk of chronic exposure to OSA.»

Mark Albers uses the olfactory system of mice and humans to help understand the early events of neurodegeneration in order to find ways to intervene early in the disease process before symptoms appear and distinguish early pathologic events from changes produced by aging.

Thinking problems in Huntington's disease take a huge toll from early in the disease.

For example, if it turned out that you were losing ganglion cells that responded to motion early in the disease, then you can imagine designing visual field tests that would detect motion in particular and tell us whether or not people were losing certain kinds of ganglion cells long before pressure increases or holes in their visual field would show up.

Many of the current drugs being explored act to stop the formation of amyloid plaques in the brain which mean they may need to be given early in the disease process.

But there's another group of PD symptoms, termed the «non-motor symptoms» (NMS) of PD, that gets far less attention, even though NMS begin to manifest earlier in the disease, are harder to treat with current therapies, and include some of the most crippling features of living with the later stages of PD.

The investigators are now testing whether treatment with TSA earlier in the disease process will work better than the delayed treatment in this study.

But the «off» retinal ganglion cell dendrites retracted very early in the disease.

So when AFFiRiS» Schneeberger opines that «given the mode of action of disease modifiers», an AS - clearing immunotherapy such as PD01A (or PRX002) is «really something we need to apply early in this disease» because «once the the brain cells are destroyed, getting them back is probably impossible,» he is adopting a view that is entirely reasonable — but only because it is constrained to the specific plank in the integrated platform that rejuvenation biotechnology must become.

So it's really something we need to apply early in this disease.»

Our results demonstrating Gleevec's high efficacy in CML tell us that in applying the drug to other cancers, we need to diagnose and treat patients earlier in the disease course.

Well, one specific event that my lab has contributed to the «Catalyst for a Cure» is we've developed high - resolution imaging methods that we can look into the eye and take very high - resolution photographs of layers in the retina that are affected early in disease.

These range from visual stimulation experiments that allow us to tap into the specific sets of retinal ganglion cells that are most vulnerable early in the disease, to the evolution of new imaging techniques, largely thanks to Alf Dubra and Vivek Srinivasan's work in those areas, and the ability to image retinal ganglion cells and their component parts like their axons which degenerate very early in glaucoma.

Finally, we know that treatment early in the disease course is associated with improved efficacy of drugs and better outcomes, such as reduced risk for surgery.

The operationalization of mild cognitive impairment (MCI) led to targeting earlier symptomatic cases of the illness and treatment strategies based less on pathology and more on a chance to halt or slow decline than there would be earlier in the disease.1 With the development of amyloid imaging, MCI due to AD diagnosis was refined, 2 and early - stage AD was extended further to include preclinical AD, 3 wherein a positive amyloid positron emission tomography (PET) scan or diagnostic low levels of cerebrospinal fluid β - amyloid (Aβ) indicated the presence of pathology in people who were cognitively normal.

What we've discovered is that those cells become active very early in the disease, they become active even before we can detect that the neuron is sick, even before the ganglion cell shows signs of degenerating, we find the glial cells are becoming very, very active and that was a surprise and we published those findings.

The idea is that inhibiting Aβ formation to reduce growth of Aβ - based plaques in the brains of Alzheimer's patients may be therapeutic, although it isn't yet clear how early in the disease process such an intervention would need to be employed to be effective.

While of obvious importance to patients, these findings are also tremendously important to hospitals and policymakers who are concerned with initiating palliative care earlier in the disease course.

The team identified a period of vulnerability for retinal ganglion cells early in the disease, when these cells are more sensitive to metabolic insults and stressors.

And what we've found is that those cells also become very active early in the disease.

Early in the disease, patients show focal anterior cingulate cortex (ACC) and orbital frontoinsula (FI) degeneration, accentuated in the right hemisphere.

However, reliable biomarkers are required to allow such growth - promoting approaches to be applied early in the disease progression.

«The more robust response rates of first - line therapy, compared with second or later lines, suggest that immunotherapy administered earlier in the disease course is more beneficial,» says Dr. Adams.

Our results suggest that earlier in the disease, regions of the posterior default mode network start to disengage whereas regions within the anterior and ventral networks enhance their connectivity.

Further, the ability to detect minute changes in these biomarkers enables the identification of at - risk patients earlier in their disease progression to guide more personalized, preventive care.

The really important questions are whether this therapy can be given safely; early in the disease course; and as second - line treatment, replacing an autologous stem cell transplant.

It also tends to act in the body's production of IL - 10 if it is taken during infection, downregulating the levels of other cytokines and necessary, but if taken early in the disease process, it inhibits viral upregulation of IL - 10 and increases antiviral cytokine production and activity.»

The damage to the joints from RA occurs early in the disease progression.

Surgery and radiotherapy are very difficult but surgical removal of the affected gland early in the disease combined with intra-operative irradiation may be successful in some cases.

«Improvement was evident only in top performing cats, suggesting that SAMe (Novifit) is most effective when used early in disease progression.»