We explored how aging affects transcriptional dynamics using single - cell RNA sequencing of unstimulated and stimulated naïve and
effector memory CD4 (+) T cells from young and old mice from two divergent species.
Effector memory CD4 + T cells mediate graft - versus - leukemia without inducing graft - versus - host disease.
The phenotype of NP cells generated ex vivo (Figure S8) closely resembles that of central memory CD4 + T cells found in vivo, which persist for years in secondary lymphoid organs and can differentiate into
effector memory CD4 + T cells [45].
Not exact matches
The spleen showed increased expansion of antigen - experienced
effector and
memory CD4 + T - cells.
Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (
effector memory T cells expressing
CD45RA) subset, which is highly enriched for
CD4 - CTLs, compared with
CD4 + T cells in the central
memory (TCM) and
effector memory (TEM) subsets.