Not exact matches
They systematically deleted genes for
secreted effector proteins — molecules that the parasite injects into a host cell to modulate the immune system during infection — and injected the altered parasites into mice with aggressive ovarian cancer.
Their results demonstrate that specific rhoptry and dense granule
effector proteins that T. gondii
secretes before and after host cell invasion, respectively, control the development of an effective host antitumor response, and increase the survival of mice with ovarian tumors.
Another
protein - based targeting strategy, TALENs, is based on the transcription activator - like
effector (
proteins secreted by Xanthomonas bacteria).
Although antimicrobial peptides are not the only functional class to be overrepresented among short,
secreted proteins encoded by members of multi-gene families, the prevalence of these properties among induced genes strongly suggests the possibly that at least some of these genes encode novel immune
effectors.