Sentences with phrase «egeblad tumor microenvironment»

The Company focuses on discovering and developing small molecule drugs directed against tumor and immune cell targets that control key metabolic pathways in the tumor microenvironment.

«We're interrogating the tumor microenvironment,» she says, «by looking at suppressive cues as well as cells and secreted proteins that protect tumors from the immune response.»

This quantitative, targeted, multiplexed approach leverages the power of next - generation sequencing and PCR technologies, and allows the researcher to obtain a molecular snapshot of the tumor microenvironment.

«This technique creates a steady, sustained release of antibodies directly into the tumor site; it is an efficient approach with enhanced retention of anti-PD-1 antibodies in the tumor microenvironment,» says Zhen Gu, an assistant professor in the biomedical engineering program and senior author of the paper.

They observed an intricate reciprocal regulation between Klotho, Wnt5A, melanoma cells, and the tumor microenvironment.

Weeraratna's team used an artificial skin reconstruct model to recreate the interactions of melanoma cells with either a young or aged tumor microenvironment.

I think they may have been missing a piece of the puzzle, by not considering aging and the tumor microenvironment.»

Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.

Where these three cells come in contact is where tumor cells can enter blood vessels — a site called a tumor microenvironment of metastasis, or TMEM.

However, tolerance - inducing mechanisms and the presence of suppressive cell types in the tumor microenvironment can dampen the response to immunotherapy.

In this rewriting of the textbooks, a tumor is not just a clump of aberrant cells; it also includes a support system, a tumor microenvironment, which encompasses a multitude of varying immune cell types and crisscrossing chemical signals, along with a network of blood vessels.

The researchers are now planning to address the impact of targeting autophagy either clinically and pharmacologically on the immune landscape of melanomas by phenotyping other immune cells in the melanoma tumor microenvironment.

When looking for culprits, researchers have often focused their microscopes on macrophages, which occupy a meaningful spot among the white blood cells in the tumor microenvironment.

The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor microenvironment in different types of solid tumors, including skin cancer.

Here, they observed that while estrogen receptor was absent in cancer cells, it was prevalent and in many cases increased in the so - called tumor microenvironment — the area around the tumor that helps it grow.

By better understanding the tumor microenvironment we can develop strategies and treatment options to neutralize its oncogenic influence and more effectively attack the tumor itself.

Mechanistic studies showed that IFN increases antitumor immune responses by enhancing antigen presentation to T cells by dendritic cells present in the tumor microenvironment.

Here, we will explore how the tumor microenvironment promotes oncogenic progression, while protecting the tumor from therapeutic intervention.

Highlight what can be learned from the tumor microenvironment that might allow better, more effective therapeutics to be developed

The paper identified two barriers: a wide variation in EGFRvIII expression in patients and a resistance in the tumor microenvironment, which researchers showed became even more immunosuppressive following CAR T cell infusion.

«The key to taking cancer vaccines to another level is combining them with immunotherapies that target the tumor microenvironment,» Kwak said.

Genetically modified «hunter» T cells successfully migrated to and penetrated a deadly type of brain tumor known as glioblastoma (GBM) in a clinical trial of the new therapy, but the cells triggered an immunosuppressive tumor microenvironment and faced a complex mutational landscape that will need to be overcome to better treat this aggressive cancer, Penn Medicine researchers report in a new study this week in Science Translational Medicine.

Timothy Wang at Columbia recently published work in Cancer Cell (DOI: 10.1016 / j.ccell.2016.11.005) that showed that recruitment of nerves into the tumor microenvironment is necessary and sufficient for stomach cancer progression, and that blocking a neurotransmitter in the nerves that line the stomach could represent a novel therapy.

«Our research shows that the protein GSK3 plays a crucial role in helping B cells meet the energy needs of their distinct states,» says Robert Rickert, Ph.D., director of the Tumor Microenvironment and Cancer Immunology Program at Sanford Burnham Prebys Medical Discovery Institute (SBP).

Numerous studies have already shown that cancer spreads particularly aggressively if there is an unfavorable balance between suppressing and active immune cells in the tumor microenvironment.

«Preclinical results support entinostat's role in targeting the tumor microenvironment: Entinostat inhibits function of myeloid derived suppressor cells resulting in enhanced antitumor effect in murine models of lung and renal cell carcinoma.»

This work shows that the tumor microenvironment itself can compromise the efficacy of targeted therapies and should be taken into account as new treatment approaches are developed.»

Learn how dendritic cells maintain a local antitumor immune response within the tumor microenvironment

The answer lies in the tumor microenvironment.

We decided to look at the exosomes of stromal cells, a type of cell that is commonly found in the tumor microenvironment, and see if stromal exosomes were influencing the energy consumption of cancer cells.»

Next, Mao and colleagues developed a way to study how genes and the tumor microenvironment influence cancer development.

They also learned key details about how genes and the cells immediately surrounding a tumor (also called the tumor microenvironment) affect cancer risk.

Entinostat Therapy Plays Favorable Role in Targeting the Tumor Microenvironment to Enhance Immune Checkpoint Therapy

Given its potential ability to block the function of immune suppressive cells in the tumor microenvironment, entinostat is also being evaluated in combination with approved PD - 1 antagonists.

«This enabled us to study how genes and the tumor microenvironment — not the tumor itself — affect tumor growth.»

We found that cancer susceptibility is related to the complex interplay between exposure to low - dose radiation, an individual mouse's genes, and their tumor microenvironment,» says Jian - Hua Mao of Berkeley Lab's Life Sciences Division.

How exactly these genetic loci affect the tumor microenvironment and cancer development is not yet entirely understood.

Ongoing projects are directed toward understanding the role that the alpha2 beta1 integrin plays in immune modulation in the tumor microenvironment.

The researchers expanded the relevance of these findings to lung carcinoma, showing that soluble antibodies are generally important in the tumor microenvironment to induce accumulation of MDSCs and promote cancer progression.

Called «tumor microenvironments of metastasis,» these on - ramps are sites on blood vessels that special immune cells flock to.

We are unraveling the mechanisms of this modulation in different solid and hematological malignancies and investigating ways to potentiate iNKT cell control of the tumor microenvironment for cancer immunotherapy.

The new study took the next logical step: Can the tumor microenvironment be altered so that it promotes or thwarts metastasis?

We expect that the CRI iAtlas will help to accelerate discovery and improve patient outcomes by providing researchers greater access to genomics data to better understand the immunological characteristics of the tumor microenvironment and its potential impact on patient responses to immunotherapy,» said Jill O'Donnell - Tormey, Ph.D., CEO and director of scientific affairs at CRI.

On a brighter note, not all breast cancer patients have the kind of tumor microenvironment in which pre-op chemo can promote metastasis.

We seek to understand the functions of MMPs in this normal physiological process to use these findings to understand the tumor microenvironment.

«This showed that the tumor microenvironment is the doorway to metastasis,» Condeelis said.

We are particularly interested in leverage our interdisciplinary expertise in polymer chemistry, nanomedicine, drug delivery and immunobiology to innovate new approaches to modulate the tumor microenvironment and enhance cellular immune responses to cancer vaccines.

Our findings show how the tumor microenvironment drives the acquisition of CD39 as an immune regulatory molecule on CD8 + T cells, with implications for defining a biomarker of T cell dysfunction and a target for immunotherapeutic intervention.

Normal wound healing shares many similarities with the tumor microenvironment, and indeed tumor invasion has been compared to «wound healing gone awry.»

Research Interests: Mechanisms of immune regulation in the breast and ovarian tumor microenvironment