Here, we describe the genotypic and phenotypic characteristics of HR - deficient EOCs, discuss current and
emerging approaches for targeting these tumors, and present challenges associated with these approaches, focusing on development and overcoming resistance.
Instead, Dr. Baselga said researchers and scientists are making strides in what he calls precision medicine,
an emerging approach for disease treatment and prevention that takes into account individual variability in environment, lifestyle and genes for each person.
This is
an emerging approach for disease treatment and prevention that takes into account the genes, environment, and lifestyle of each person.
Not exact matches
There isn't a one - size - fits - all
approach for how to set up these
emerging roles.
The Army has purchased an
emerging technology
for Abrams tanks, Bradleys and Strykers designed to give combat vehicles an opportunity identify, track and destroy
approaching enemy rocket - propelled grenades in a matter of milliseconds, service officials said.
One thing is certain: If Patagonia does see growth from this
approach, a new arrow will
emerge for placement in companies» growth quivers.
Based on this, five common company
approaches emerged, which were classified into customer - care personas — none of which were absolutely perfect in dealing with customer service and each leaving room
for improvement.
Tan's book is both a case study
for a western audience of the
emerging Chinese
approach to innovation and a text on innovation generally — still a concept poorly understood in concrete terms.
Recent conferences have focused on the Forum's
emerging research on mergers and acquisitions, as well as new
approaches to and theories
for investment strategy.
One
approach which has been the boilerplate
for a number of
emerging market countries, including that of Brazil, is that practised by the Bank of England.
As part of the Swiss government's pro-innovation push, FINMA defined its strategic goals
for 2017 - 2020, setting its priorities on proper business conduct, and
approaching supervision and regulation in a way that should encourage
emerging technologies.
Alongside such
approaches as faith - based investing or fossil - fuel divestment, gender diversity investing has
emerged as another option
for investors.
Look
for more SaaS 2.0 companies to
emerge that reimagine the entire experience in a new, more personal
approach.
Here, a good umbrella
approach is Vanguard STAR Total International (up 11.7 %
for 1997 to July 1), which seeks to follow the performance of the EAFE index and its Select
Emerging Markets Free index.
With valuations
for oil and gas stocks
approaching decade lows, BMO Capital Markets analyst Randy Ollenberger believes opportunities are
emerging.
Living at home
for a time is, therefore, a rejection of an ideal that no longer exists — if ever it had — and a practical
approach to an
emerging socioeconomic reality.
My aim in the following sections is to illustrate this third
approach by discussing two proposals
for Christian self - understanding that
emerge from a dialogue with Buddhism.
Given the deep partisan divide in the midst of our prevailing two - party system, I am convinced that new and innovative
approaches to politics will
emerge from the grassroots, as citizens recognize the health of their neighborhoods as something worth fighting
for.
The fresh
approach will see a new intelligence system
for the substances developed to reduce the length of time between drug - related harms
emerging and effective responses being prepared.
Underpinning all this is the sense that the Oyston's deliberately frugal
approach to the Premier League was been
for their own benefit and profit, rather than the club's, a sense that was reinforced in 2012 when it
emerged that Karl had paid an # 11 milion salary ($ 16.7 million USD at current exchange rates) to a company owned by his father, and a total of # 26 million to connected companies.
A conflicting report has since
emerged though, with The Guardian reporting that Giroud is now set to sign
for Chelsea in a deal worth # 17.5 m, and so it remains to be seen whether or not that speeds everything up with the Wednesday transfer deadline fast
approaching.
Stories
emerged from the Italian media via Gazetto Della Sport — and repeated on a UK website — that the Serie A club had made an
approach and were waiting
for a Hammers response.
«From my work in the youth sports trenches over the last seventeen years, I know that it is only by taking such a holistic
approach to youth sports safety, one which involves all stakeholders as part of the safety team, can we work towards a safer sports experience
for children, teens, and
emerging adults,» de Lench said.
Several points and questions
emerged as key issues to focus on as organisations plan more father - inclusive
approaches for the future:
Over the years, a mainstream
approach to Christian parenting has
emerged, and it's one that promotes sleep training and feeding schedules
for infants, warns that spoiled children and marital discord are certain by - products of homes where newborns are over-indulged, and promotes these methods as the Biblical way to care
for a new baby.
Also, at about the same time, the «child - centered
approach»
for potty training was
emerging and the idea of respecting your child's wishes and needs; waiting until your child is ready to potty train were being recommended by pediatrians such as Dr. T. Berry Brazelton and by the American Academy of Pediatrics guidelines on potty training.
The following models
emerged as possible
approaches for leveraging resources and partnerships to improve and enhance school meal programs.
«Whiles at the spot, the five (5) armed robbers
emerged, with two of them wielding pump action guns and a locally manufactured pistol waiting
for the victim to
approach.»
They
emerge from UJI's current line of reasearch into such enzyme - inhibiting structures, looking
for ways to both mitigate the typical side - effects of current treatment
approaches and shift even the most resistant tropical infections.
The researchers believe that their
approach should also enable them to quickly develop diagnostic tests
for other related viruses that might
emerge in the future.
Those treated with EST showed a marked increase in social - cognitive behaviors, but it took nearly nine months longer
for such benefits to
emerge compared to adults treated with CET, suggesting that the more intensive training offered in that
approach may help speed improvement.
Photodynamic detection and therapy has recently
emerged as a promising
approach for diagnosing and treating cancer.
«This
approach could inspire better surgical training tools and implantable heart devices, and opens new possibilities in the
emerging field of soft robotics
for devices that assist other organs as well.»
«As with many therapies in medicine today, evidence is
emerging that a more personalized
approach is likely the best
approach when determining how much vitamin D is optimal
for an individual.
Far more intelligent and humane would be a reasoned
approach to reducing graduate and postdoc programs, establishing better ways of staffing research labs, and preparing the young scientists
emerging from America's universities
for appealing career opportunities — that use their scientific training — both off and on campus.
«The
approach ticks many of the boxes
for diagnosis of
emerging viruses, including the ability to rapidly redesign the test to recognise a novel virus,» she says.
Our
approach to confronting these challenges is to center the workshop on research findings
emerging from the SciSIP awards; provide
for independent, collegial commentary on these presentations by individuals whose work has spanned, or crossed over, implementing and writing about science policy (and who have not applied
for SciSIP awards); and then to carefully roll out a distillation of findings from SciSIP awards to federal agencies and other organizations more directly involved in the formulation or implementation of science policy.
The Center
for Cancer Immunology Research (CCIR) addresses immunology - based
approaches to the treatment of cancer and has
emerged as a one - of - a-kind cancer immunology research program that allows laboratory immunologists to work with clinical oncologists to develop new or improved forms of cancer immunotherapy that activate and instruct our immune system to eliminate cancer and prevent its recurrence.
The «TGF beta» clinical trial, named
for one of the elements that distinguish this
approach, is part of an
emerging class of immunotherapies that employ adoptive cell transfer.
This specificity in treatment fits with an
emerging approach in cancer treatment nationwide, known as personalized medicine, in which the therapies
for each patient are selected based on the genes altered in their tumors.
By the early 1980s, Columbia University had begun to
emerge as a pioneering center
for molecular
approaches to the study of brain function.
Specifically, U-PGx will investigate if the
emerging approach of pre-emptive genotyping of an entire panel of important pharmacogenomics markers is cost - effective and results in a better outcome
for patients.
But ancient - DNA sequencing is beginning to shed some light on the issue.11
For example, by comparing a human HAR sequence with the HAR sequence of an archaic hominin, researchers can estimate if the HAR mutated before, after, or during the time period of our common ancestor.12 This
approach has revealed that the rate at which HAR mutations
emerged was slightly higher before we split from Neanderthals and Denisovans.3, 13 As a result, most HAR mutations are millions of years old and shared with these extinct hominins (but not with chimpanzees).
Muthumani's research interest is in the area of immune
approaches to
emerging infectious diseases and immune therapy
approaches for the treatment cancer.
The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way
for an era of «genomic medicine,» in which new diagnostic and therapeutic
approaches to common multifactorial conditions are
emerging.
The Graeme Clark Institute
for Biomedical Engineering promotes and coordinates the extensive bioengineering activities that exist across The University of Melbourne, drawing on
emerging scientific and engineering
approaches to drive transformative clinical solutions.
The
approach is to use clinically relevant tumor models such as patient - derived xenografts (PDXs), as well as humanized and immunocompetent transgenic tumor - bearing mice to design rational combinations of novel and
emerging cancer therapies, including tumor - targeting and immune - stimulating therapies, to ultimately improve treatment outcomes
for cancer patients.
As the science and its applications develop, a comprehensive
approach to addressing ethical and social issues of
emerging technologies as a whole is called
for if scarce intellectual resources are to be used optimally, according to a new report authored by Erik Parens, Josephine Johnston, and Jacob Moses of The Hastings Center.
Clinics that offer a broader, team - based
approach to treating psoriasis are also beginning to
emerge, says dermatologist Andrew Blauvelt, MD, a professor at Oregon Health & Science University in Portland and the research director of the universitys Center of Excellence
for Psoriasis and Psoriatic Arthritis, which combines the efforts of dermatologists, rheumatologists, and psychiatrists.
While many of today's tools were not yet available in 1991, IFM was already focused on using this
emerging knowledge to adapt therapies to the patient (rather than the reverse) by training clinicians to examine the genetic and epigenetic factors
for each patient and to develop an individualized therapeutic
approach that addresses these underlying factors.