Not exact matches
Our findings shed new light on the molecular mechanisms through
which LA induces antiproliferative and pro-apoptotic responses in both breast and
endometrial cancer
cells toward its usefulness in more comprehensive therapeutic approaches.
Next, we found that the increase of p21Cip1 / WAF1 expression,
which occurs upon LA exposure in a p53 - independent manner, is involved in the apoptotic effects prompted by LA in both breast and
endometrial cancer
cells.
Studies demonstrated that Dioxin exposure to normal
endometrial cells resulted in a loss of normal progesterone responsiveness (progesterone resistance)
which is a striking feature of endometriosis.
Obesity causes elevated amounts of estrogen (secreted by fat
cells)
which can drive genesis of certain cancers like breast and
endometrial cancer
Here, we provide novel insights regarding the molecular mechanisms through
which LA triggers antiproliferative and pro-apoptotic effects in both breast and
endometrial cancer
cells.»