Sentences with phrase «endosomal tlrs»

A defective endosomal — lysosomal autophagy pathway (due to either a primary defect in this pathway or dysfunctional mitochondria) could be the common denominator in various forms of ALS.

Inhibition of Vps34 activity will affect both autophagy and endosomal trafficking.

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

After finally receiving Mirkin's thin - optical microscopy data by air mail, Lévy and Mason re-analyzed it and determined the absence of any evidence for endosomal escape, while all Sticky - Flare particles appeared to be localized exclusively inside vesicular membrane compartments, i.e., endosomes (Mason & Levy, bioRxiv 2015).

A fluorochrome - modified DNA complement to the aptamer was synthesized for co-localization of aptamers and QDs, proving effective endosomal escape for both components.

Feng Z. p53 regulation of the IGF - 1 / AKT / mTOR pathways and the endosomal compartment.

Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1 gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting

They are, however, limited by «biological barriers» such as renal clearance, endosomal attack, and degradation by serum endonucleases (14).

We also investigate the mechanisms that in dendritic cells allow for early endosomal escape of antigens leading to subsequent crosspresentation to CD8 + cytotoxic T lymphocytes.

These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type - I IFN - induced JAK / STAT signalling and gene transcription.

Christianson syndrome (CS) is a newly recognized X-linked neurogenetic disorder caused by changes in the SLC9A6 gene encoding the endosomal Na + / H + exchanger 6 (NHE6) protein.

We identified interactions between the TGN - localized putative t - SNAREs syntaxin 6, syntaxin 16, and Vti1a, and two early / recycling endosomal v - SNAREs, VAMP3 / cellubrevin, and VAMP4.

CS is caused by deleterious mutations in SLC9A6, an X-linked gene that codes for the endosomal Na + / H + exchanger 6 (NHE6), which is believed to be involved with circuit development [2, 3].

Transactivation of the PAR1 - PAR2 heterodimer by thrombin elicits β - arrestin - mediated endosomal signaling.

Recruitment of Uev1B to Hrs - containing endosomes and its effect on endosomal trafficking.

Roberto Villasenor (Zerial, MPG)-- «Regulation of signal transduction by endosomal EGFR distribution» (2012)

Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch.

Rab7 Mutants Associated with Charcot - Marie - Tooth Disease Cause Delayed Growth Factor Receptor Transport and Altered Endosomal and Nuclear Signaling.

The job holder will be responsible for progress hands on research projects to characterize and develop new drug conjugates for cell - targeting and in depth understanding of the endosomal uptake mechanism.

A presynaptic endosomal trafficking pathway controls synaptic growth signaling.

This revealed design principles of the endosomal system and the role of the endosomal network in signal transduction.

Maike Gravert (Walch - Solimena, MPG)-- «Novel regulators of trafficking in the yeast Golgi - endosomal system» (2006)

Endosomal signaling of the tomato leucine - rich repeat receptor - like protein LeEix2.

Regulation of endosomal membrane traffic by a Gadkin / AP -1 / kinesin KIF5 complex.

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells.

Differential subcellular distribution of endosomal compartments and the dopamine transporter in dopaminergic neurons.

This paper shows the importance of endosomal MyD88 — IRF7 signalling for robust induction of type I IFN genes in pDCs.

Retromer binds the late endosomal Rab Ypt7 (blue) and recycles sorting receptors to the Golgi apparatus (green arrows).

The endosomal phenotype in Down syndrome.

Current model of endosomal maturation and cargo sorting at the endosome - vacuole interface.

Rao and her team hope that pinpointing the importance of this trafficking mechanism in autism spectrum disorders may lead to the development of new drugs for autism that alter endosomal pH. As the use of genomic data becomes increasingly commonplace in the future, the step-wise strategy devised by her team can be used to screen gene variants and identify at - risk patients, she says.

This down - regulation was achieved by a heterologous, protein synthesis - dependent activation of the endosomal pathway, which leads to internalization and apparent degradation of apCAM.

This endosomal pathway normally breaks things down to absorb and recycle their components, but Ebola virus hijacks the pathway's functions to infiltrate cells.

At this stage, Ebola virus, enveloped in its own membrane, fuses with the cell's endosomal compartment membrane to release the virus» genes into the cell's inner workings.

The experiments have shown that the inhibition of endosomal acidification prevents the activation of P45 - IKKα and specifically inhibits the growth of cancer cells with mutant BRAF, both in vitro and in vivo.

In the study published in the journal Science Signaling, the team led by LLuís Espinosa, investigator of IMIM's research group into stem cells and cancer, have shown that inhibition of endosomal activity is a potential therapeutic strategy for the treatment of cancers with the BRAF mutated gene.

«We show that these endosomal inhibitors, currently used in, for example, the prevention and treatment of malaria can be used to prevent metastasis of colorectal cancer, without increasing the toxicity of standard treatments.