Sentences with phrase «endothelial cell activation»
Endothelial cell activation, vascular smooth muscle dysfunction, oxidative stress, and inflammation, mechanisms which underlie heart disease, diabetes, and hypertension, are all variables which can precipitate or perpetuate immune imbalances in autoimmune disease.
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Activation of endothelial cells elicits a complex series of responses that include the elaboration of proteolytic enzymes, migration, and proliferation.
The onset of angiogenesis appears to be the result of an imbalance between stimulatory and inhibitory factors that leads to the activation of previously quiescent endothelial cells (4, 5).
It would seem, therefore, that cellular division has at least one significant negative control component in both rabbit and human corneal endothelial cells whose activation may be delayed.
Hyperosmolarity attenuates TNF - α — mediated proinflammatory activation of human pulmonary microvascular endothelial cells.
The adaptor CRADD / RAIDD controls activation of endothelial cells by proinflammatory stimuli.
Release of cytochrome c, Bax migration, Bid cleavage, and activation of caspases 2, 3, 6, 7, 8, and 9 during endothelial cell apoptosis.
Receptor - mediated activation of nitric oxide synthesis by arginine in endothelial cells.
Cholesterol - dependent and - independent CD40 internalization and signaling activation in cardiovascular endothelial cells.
A vascular injury model using focal heat - induced activation of endothelial cells.
Increased MAPK activation and impaired insulin signaling in subcutaneous microvascular endothelial cells in type 2 diabetes: the role of endothelin - 1
«The second step involving Akt activation by R - Ras stabilizes the microtubule cytoskeleton in endothelial cells, creating a steady architecture that promotes lumen formation.»
From these cell based and clinical studies, we have developed important mechanistic ideas such as activation of protein kinase C, the role of vascular endothelial growth factor (VEGF) and selective insulin resistance as some of the basic mechanisms for the pathogenesis of diabetic microvascular and cardiovascular diseases which are now widely studied by multiple laboratories.
Josin researchers made two major findings: They identified the mechanisms by which GLP - 1 can induce protective actions on the glomerular (renal) endothelial cells by inhibiting the signaling pathway of Ang II and its pro-inflammatory effect; and demonstrated a dual signaling mechanism by which hyperglycemia, via PKCβ activation, can increase Ang II action and inhibit GLP - 1's protective effects by reducing the expression of GLP - 1 receptors in the glomerular endothelial cells.
Three recent experimental studies focused on low consumption / exposure.949596 In one study, 29 smokers each consumed a single cigarette, immediately after which they had a significant decrease in blood vessel output power and significant increase in blood vessel ageing level and remaining blood volume 25 minutes later, as markers of atherosclerosis.94 In another study, human coronary artery endothelial cells were exposed to the smoke equivalent to one cigarette, which led to activation of oxidant stress sensing transcription factor NFR2 and up - regulation of cytochrome p450, considered to have a role in the development of heart disease.95 These effects were not seen when heart cells were exposed to the vapour from one e - cigarette.95 A study exposed adult mice to low intensity tobacco smoke (two cigarettes) for one to two months and found adverse histopathological effects on brain cells.96
Activation of Signal Transducer and Activator of Transcription 1 (STAT1) Is Not Sufficient for the Induction of STAT1 - dependent Genes in Endothelial Cells: COMPARISON OF INTERFERON --LCB- gamma -RCB- AND ONCOSTATIN M
Cutting Edge: Class II Transactivator - Independent Endothelial Cell MHC Class II Gene Activation Induced by Lymphocyte Adhesion
Elevated plasma concentrations of soluble forms of endothelial adhesion molecules, released from shedding or proteolytic cleavage from the endothelial cell surface, are considered useful indicators of endothelial dysfunction and activation (20, 25).
Ishikado, A. Sono, Y. Matsumoto, M. Robida - Stubbs, S. Okuno, A. Goto, M. King, G. Blackwell, K. Makinoa, T. Willow bark extract increases antioxidant enzymes and reduces oxidative stress through activation of Nrf2 in vascular endothelial cells and Caenorhabditis elegans.
Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K / Akt and ERK1 / 2 signaling
Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state.
Glucose oscillations, more than constant high glucose, induce p53 activation and a metabolic memory in human endothelial cells