Endothelial cells lining blood vessels help keep what belongs in and what doesn't belong out.
Not exact matches
The Weill Cornell researchers» process was more direct: Four transcription factors prompted adult mouse
endothelial cells, which
line the inside of
blood vessels, to turn into HSCs.
In experiments conducted on human lung
endothelial cells and in mice, the researchers showed that NS1 caused permeability of the endothelium, which
lines the walls of
blood and lymph
vessels.
Epithelial
cells form tissue layers that cover our skin and the inner surfaces of most of our internal organs, while
endothelial cells line the adjacent
blood - transporting
vessels and capillaries that support their functions.
In their latest study, Guarente and his colleagues decided to explore the role of sirtuins in
endothelial cells, which
line the inside of
blood vessels.
Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on
endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent
blood vessels.
Current thinking regarding type III hypersensitivity is that immune
cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the
endothelial cells lining adjacent
blood vessels to promote the recruitment of neutrophils.
In earlier studies involving animal models and human cancer
cell lines, researchers found that breast cancer spreads when three specific
cells are in direct contact: an
endothelial cell (a type of
cell that
lines the
blood vessels), a perivascular macrophage (a type of immune
cell found near
blood vessels), and a tumor
cell that produces high levels of Mena, a protein that enhances a cancer
cell's ability to spread.
In the current study, the researchers report that NOTCH1 acts like a sensor on the
endothelial cells — the
cells that
line the valve and
vessels — detecting
blood flow outside of the
cell and transmitting information to a network of genes inside the
cell.
The researchers then differentiated the iPS
cells into
endothelial cells, which
line the interior of the heart and
blood vessels, before transplantation.
To determine whether
endothelial cells — the
cells that
line the interior surface of
blood vessels — directly influence breast cancer
cell growth, they then created unique organotypic models of lung and bone marrow microvascular niches, in which
endothelial cells formed
blood vessel - like structures in culture as they would in the original organ.
In the chamber, tubes about the thickness of a human hair were
lined with
endothelial cells as in natural
blood vessels.
Using a powerful imaging technique that allowed the scientists to track the presence and movement of parasites in living tissues, the researchers found that Toxoplasma infects the brain's
endothelial cells, which
line blood vessels, reproduces inside of them, and then moves on to invade the central nervous system.
«
Endothelial cells make up the inner
lining of
blood vessels,» said William Durante, Ph.D., professor of medical pharmacology and physiology at the MU School of Medicine and lead author of the study.
The study, published in Proceedings of the National Academy of Sciences, found that rod - shaped nanoparticles — or nanorods — as opposed to spherical nanoparticles, appear to adhere more effectively to the surface of
endothelial cells that
line the inside of
blood vessels.
It both promotes angiogenesis within the tumor and increased the migration of
endothelial cells, which form the inner
lining of
blood vessels.
«Up to now, the Tie2 receptor has only been known in
endothelial cells that
line the inside of
blood vessels,» Milde said.
Instead of dispensing ink, Organovo's bioprinter uses two robotic tips to deposit globs of
cells — in this case,
endothelial cells that
line blood -
vessel walls, smooth muscle
cells that regulate
vessel dilation and contraction, and structural fibroblast
cells.
Among other effects, immune
cells disrupt the function of the
endothelial layer, the
lining of the
blood vessels, counteracting «all the good things that the
endothelial cells produce,» says physiologist Brett Mitchell of Texas A&M College of Medicine in College Station.
A specific lung - targeting molecule is attached to the carrier's surface and the steriod, dexamethasone, an anti-inflammatory, is loaded into the nanogel, which then binds to lung
endothelial cells lining the inside wall of the
blood vessels where it rapidly delivers the drug.
In an effort to overcome these limitations, a team at the Wyss Institute for Biologically Inspired Engineering led by its Founding Director, Donald Ingber, M.D., Ph.D., had previously engineered a microfluidic «Organ - on - a-Chip» (Organ Chip) culture device in which
cells from a human intestinal
cell line originally isolated from a tumor were cultured in one of two parallel running channels, separated by a porous matrix - coated membrane from human
blood vessel - derived
endothelial cells in the adjacent channel.
Malaria parasites grow in red
blood cells and stick to the
endothelial lining of
blood vessels through a large family of parasite proteins called PfEMP1.
That's because experiments conducted on the International Space Station involving
cells that
line the inner surfaces of
blood vessels (
endothelial cells) show that microgravity accelerates cardiovascular disease and the biological aging of these
cells.
To study this barrier and determine why a lack of
blood flow causes it to leak, the researchers built a
blood -
vessel - on - a-chip model consisting of a channel
lined with a layer of human
endothelial cells surrounded by extracellular matrix within a microfluidic device, which allowed them to easily simulate and control the flow of
blood through a
vessel and evaluate the
cells» responses.
The force of that
blood flow helps keep the
cells that
line the
blood vessels, called
endothelial cells, healthy; when
blood flow is disrupted, such as during surgical procedures or a stroke, the
vessels start to leak, which can cause a host of inflammatory responses that lead to
cell damage and disease.
The transplanted stem
cells had differentiated into
endothelial cells — which form the inner
lining of a
blood vessel, providing a barrier between
blood and spinal cord tissue — and attached to capillaries in the spinal cord.
This environment includes
endothelial cells (the
cells lining the inside of
blood vessels) and extracellular matrix (ECM) components, which provide structural support and signaling to surrounding
cells.
At that key point, Takebe added two more types of
cell known to help to recreate organ - like function in animals:
endothelial cells, which
line blood vessels, taken from an umbilical cord; and mesenchymal
cells, which can differentiate into bone, cartilage or fat, taken from bone marrow.
The study focuses on
endothelial cells, the
cells lining the inside of
blood vessels in which atherosclerotic plaques develop.
Endothelial progenitor
cells (EPCs) differentiate into the
cells that make up the
lining of
blood vessels, and so play roles in vasculogenesis and angiogenesis.
With potential therapeutic implications, Stainier and a colleague also recently discovered that
endothelial cells, which
line the
blood vessels, play a critical role in inducing the development, or proper differentiation, of red
blood cells, the transporters of oxygen.
The most potent of these, known as effector memory T
cells, are activated by a group of proteins known as human leukocyte antigens (HLAs) on the surface of
endothelial cells lining the donated organ's
blood vessels.
Endothelial cells line the inside of all
blood vessels and regulate inflammation,
blood clotting following injury and
blood pressure levels.
The
vessel formed on the chip includes a channel
lined by human
endothelial cells and perfused with human whole
blood.
They then transformed these iPSCs into
endothelial cells, which
line heart valves and
blood vessels.
A team at the Harvard John A. Paulson School for Engineering and Applied Sciences (SEAS) and the Wyss Institute for Biologically Inspired Engineering at Harvard University has invented a method for 3D bioprinting thick vascularized tissue constructs composed of human stem
cells, extracellular matrix, and circulatory channels
lined with
endothelial blood vessel cells.
A team led by Young - sup Yoon, MD, PhD developed a new method for generating
endothelial cells, which make up the
lining of
blood vessels, from human induced pluripotent stem
cells..
Microscope image showing malaria - infected red
blood cells (small round
cells containing the parasite [dark dots]-RRB- sticking to brain
endothelial cells (large blue - ish
cells) that
line the
blood vessels supplying the brain.
Chunhui Xu's lab in the Department of Pediatrics recently published a paper in Stem
Cell Reports on the differentiation of
endothelial cells, which
line and maintain
blood vessels.
Its also possible, experts say, that C enhances the functioning of
endothelial cells (which
line the inside of all
blood vessels), slowing artery clogging and lowering
blood pressure.
Our
endothelial cells are within our
blood vessels lining their walls.
Homocysteine is toxic to the
endothelial cells that
line blood vessels.
Researchers report that curcumin reduces all pro-inflammatory molecules in cartilage
cells and in membranes that
line the joints, among them tumor necrosis factor — which destroys joint cartilage — and vascular
endothelial growth factor, which promotes excessive growth of
blood vessels in inflamed joints.
The most likely organ to be affected is the gut, which is directly exposed to food;
endothelial cells, which
line blood vessel walls, and immune
cells which circulate in
blood, as
blood is the next location after the gut exposed to food molecules entering the body; and lastly organs which interact closely with the
blood, such as the thyroid.
Hemangiosarcoma An incurable tumor of
cells that
line blood vessels (
endothelial cells).
Until recently, it was generally accepted that the tumors arise from
endothelial (
blood vessel lining)
cells.
Hemangiosarcoma is a cancer of
endothelial cells — the
cells that
line blood vessels.
It is an incurable tumor of
cells that
line blood vessels, called vascular
endothelial cells.
Hemangiosarcoma is a tumor that develops from
cells that
line blood vessels (
endothelial cells).