Sentences with phrase «env gp120»

HIV - 1 Env gp120 C2V5 Potential N - Linked Glycosylation Site (s)(PNGs) Variations and Amino Acid Length Polymorphisms among Infected Family Members

Not exact matches

Esparza stresses that no one really knows how the differences between the various subtypes — in the sequence of their env gene, and structure of their gp120 — will affect people's immune responses.

In this study, we identified three new broadly neutralizing VHH, which bind to the CD4 - binding site of the Env subunit gp120 and bind the molecular probe used to isolate VRC01.

SIV env gp160 / gp120.

Env gp160 is expressed in infected cells, cleavage to gp120 and pg41 does not occur and syncitium formation not observed.

Using an integrative approach that combined electron microscopy on the Env trimer complex with PGT151 (led by the Ward lab) with the structure of the PGT151 Fab by x-ray crystallography (led by the Wilson lab), the scientists were able to visualize the location of the PGT151 - series binding site on the Env trimer — which includes a spot on one gp41 protein with two associated sugars (glycans), a patch on the gp120 protein and even a piece of the adjacent gp41 within the trimer structure — «a very complex epitope,» said Claudia Blattner, a research associate in the Wilson laboratory at TSRI and member of the IAVI Neutralizing Antibody Center who, along with graduate student Jeong Hyun Lee, was a first author of the second paper.

Curiously, despite their broad neutralizing ability, these antibodies did not bind to any previously described vulnerable sites, or epitopes, on Env — and indeed failed to bind tightly anywhere on purified copies of gp120 or gp41, the two protein subunits of Env.

In fact, gp120 and gp41 assemble into an Env structure not as one gp120 - gp41 combination but as three intertwined ones — a trimer, in biologists» parlance.