Sentences with phrase «env protein»

She received a Civilian Special Acts award for her leadership in the development and evaluation of a Tanzanian subtype C Env protein from acute HIV infection.

The ECL2 was chosen because this region is less well conserved amongst the CXC family of chemokine receptors, which should reduce the frequency with which other CXC receptors might be targeted, and because ECL2 is important in supporting interactions with the HIV - 1 Env protein [37], [38].

Antibody responses particularly to Gag and Env proteins are hallmarks of immune responses to retroviral infections including experimental XMRV infection of macaques [22].

XMRV and PMLV are highly related sharing between 87 - 94 % nucleotide identity across their genomes and 88 - 97 % and 88 - 91 % amino acid identity to complete Gag and Env proteins, respectively.

We used a new WB assay to test for anti-XMRV antibodies and showed by using both monoclonal antibodies and polyclonal antisera that this assay detected specifically, and with high titers, reactivity to both XMRV and MuLV Gag and Env proteins.

An aliquot of coded plasma from the CFS and healthy controls was tested at RKI by an ELISA using recombinant Gag and Env proteins used recently to investigate XMRV infection in German prostate cancer patients [14].

Not exact matches

The research team used single - gene amplification to study the gene responsible for HIV's major surface protein, env.

The researchers have studied analyses of the genetic material of viruses found in newly infected people and, in particular, the gene env, which codes for the protein envelope or «coat» around the virus.

For HIV to infect cells, the viral envelope (Env) protein must bind to the host protein CD4 and then to a coreceptor, most commonly CCR5 (R5 HIV)(reviewed in [1]-RRB-.

(Env, Gag, and Pol are three major HIV proteins.)

We also turned our attention to HIV - 1 and found several such epitopes in the envelope (Env) protein of HIV - 1, one of which was included in both the HIV - 1 E and HIV - 1 B Env antigens that were used in the «moderately effective» HIV RV144 trial in Thailand.

One of the viral genes, env, specifies a protein that forms the viral envelope, the outer covering of the virus that interacts with a target receptor on the surface of lung cells.

A different viral envelope protein (Env), usually from VSV - G due to wide infectivity, is often used as a substitute for HIV - 1 Env, which can only infect CD4 + cells.

To characterize the isolate that replicated in HeLa cells, a 166 - bp RNA sequence containing the variable region C of the envelope (Env) surface protein was PCR - amplified from infected HeLa cell tissue culture supernatants.

The main focus of the program is inducing broad responses against the diverse HIV surface protein, Env.

Additional blinded screening of the 51 cases and 53 controls at the Robert Koch Institute using an ELISA employing recombinant Gag and Env XMRV proteins identified weak seroreactivity in one CFS case and a healthy control, which was not confirmed by immunofluorescence.

Using an integrative approach that combined electron microscopy on the Env trimer complex with PGT151 (led by the Ward lab) with the structure of the PGT151 Fab by x-ray crystallography (led by the Wilson lab), the scientists were able to visualize the location of the PGT151 - series binding site on the Env trimer — which includes a spot on one gp41 protein with two associated sugars (glycans), a patch on the gp120 protein and even a piece of the adjacent gp41 within the trimer structure — «a very complex epitope,» said Claudia Blattner, a research associate in the Wilson laboratory at TSRI and member of the IAVI Neutralizing Antibody Center who, along with graduate student Jeong Hyun Lee, was a first author of the second paper.

Curiously, despite their broad neutralizing ability, these antibodies did not bind to any previously described vulnerable sites, or epitopes, on Env — and indeed failed to bind tightly anywhere on purified copies of gp120 or gp41, the two protein subunits of Env.