Sentences with phrase «env trimers»

Sanders et al. compared rabbits and monkeys immunized with Env trimers that adopt a nativelike conformation.

PGT151 and 152 (which are nearly identical) turned out to have a binding site that occurs only on this mature and properly assembled Env trimer structure.

A surprise finding was that the PGT151 - series antibodies bind to the Env trimer in a way that stabilizes its otherwise fragile structure.

«These are the first HIV neutralizing antibodies we've found that unequivocally distinguish mature Env trimer from all other forms of Env,» said Falkowska.

Using an integrative approach that combined electron microscopy on the Env trimer complex with PGT151 (led by the Ward lab) with the structure of the PGT151 Fab by x-ray crystallography (led by the Wilson lab), the scientists were able to visualize the location of the PGT151 - series binding site on the Env trimer — which includes a spot on one gp41 protein with two associated sugars (glycans), a patch on the gp120 protein and even a piece of the adjacent gp41 within the trimer structure — «a very complex epitope,» said Claudia Blattner, a research associate in the Wilson laboratory at TSRI and member of the IAVI Neutralizing Antibody Center who, along with graduate student Jeong Hyun Lee, was a first author of the second paper.

Not exact matches

Thus, our findings indicate that native - like trimers represent a promising starting point for the further development of recombinant Env immunogens intended to broaden the NAb response.

In fact, gp120 and gp41 assemble into an Env structure not as one gp120 - gp41 combination but as three intertwined ones — a trimer, in biologists» parlance.