Sentences with phrase «epigenetic modification increases»
«Epigenetic modification increases susceptibility to obesity and predicts fatty liver.»
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Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.
«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.
«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.
There has been a rapidly increasing interest in whether environmental factors modulate the establishment and maintenance of epigenetic modifications, and thereby affect gene expression and phenotype in humans and wildlife.
Epigenetics provides another way of understanding how genes and environment interact in that there is increasing evidence that gene expression is moderated by the environment in which the organism grows and develops.15 Genetic information is encoded not just in DNA linear sequences but in epigenetic changes in chromatin structure such as DNA methylation or covalent modifications of the DNA - binding proteins.