Sentences with phrase «epigenetic study of»

«Epigenetic study of lactose intolerance may shed light on the origin of mental illness.»

This study has provided a framework for DNA methylation from saliva and has shown the way for the use of saliva DNA in epigenetic studies of psychiatric disorders.

Not exact matches

Because epigenetics is the real driver of your health status, and diet plays a major role in gene expression (aka epigenetics), at least in this post's animal study!

I would like to see studies that focussed on African Americans who are multigenerational «Jack and Jill» members, although that would perhaps not completely override potential epigenetic effects of hundreds of years of slavery and Jim Crow.

Follow - up studies confirm the effect lasts into the toddler years, and researchers have connected the phenomenon to epigenetics, or long - term alterations of DNA function (Sharp et al 2015; Pickles et al 2016).

«Our study suggests that epigenetic changes to cells treated with cigarette smoke sensitize airway cells to genetic mutations known to cause lung cancers,» says Stephen Baylin, M.D., the Virginia and D.K. Ludwig Professor for Cancer Research and professor of oncology at the Johns Hopkins Kimmel Cancer Center.

Baylin and Johns Hopkins scientist Michelle Vaz, Ph.D., first author on the study, suspected that the interplay of epigenetic and genetic changes may occur when normal lung cells develop into cancer, but, Baylin says, the timing of such changes was unknown.

According to Dana C. Dolinoy, PhD, University of Michigan School of Public Health, «many toxicologists may already be studying epigenetic phenomena — they just might not realize it.»

Professor Keith Godfrey, from the Medical Research Council Lifecourse Epidemiology Unit and the National Institute for Health Research Southampton Biomedical Research Centre, and a member of the study team, said: «The new findings provide the first direct evidence linking faltering of a baby's growth in the womb with epigenetic modifications that themselves may increase the risk of childhood obesity.

Specifically, the study reveals a mechanism that helps explain how dividing cells pass patterns of epigenetic information called methyl tags to their daughter cells, a crucial part of regulating gene expression across cell generations.

«Our study shows that epigenetic drift, which is characterized by gains and losses in DNA methylation in the genome over time, occurs more rapidly in mice than in monkeys and more rapidly in monkeys than in humans,» explains Jean - Pierre Issa, MD, Director of the Fels Institute for Cancer Research at LKSOM, and senior investigator on the new study.

Epigenetics involves the study of the circumstances that cause genes to be activated or silenced.

Therefore, toxicologists who research health, exposure - related disease, and susceptibility are actually concurrently studying the consequences of epigenetic regulation.

DNA methylation, or the addition of methyl tags to DNA, is one of the most well - studied epigenetic signals; errors in this process are commonly found in cancer.

«Epigenetics of addiction: Epigenetic study untangles addiction and relapse in the brain.»

«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»

, 1968 Zick Rubin, «The Social Psychology of Romantic Love», 1969 Elliot Aronson, «Some Antecedents of Interpersonal Attraction», 1970 David C. Glass and Jerome E. Singer, «The Urban Condition: Its Stresses and Adaptations — Experimental Studies of Behavioral Consequences of Exposure to Aversive Events», 1971 Norman H. Anderson, «Information Integration Theory: A Brief Survey», 1972 Lenora Greenbaum, «Socio - Cultural Influences on Decision Making: An Illustrative Investigation of Possession - Trance in Sub-Saharan Africa», 1973 William E. McAuliffe and Robert A. Gordon, «A Test of Lindesmith's Theory of Addiction: The Frequency of Euphoria Among Long - Term Addicts», 1974 R. B. Zajonc and Gregory B. Markus, «Intellectual Environment and Intelligence», 1975 Johnathan Kelley and Herbert S. Klein, «Revolution and the Rebirth of Inequality: The Bolivian National Revolution», 1977 Murray Melbin, «Night as Frontier», 1978 Ronald S. Wilson, «Synchronies in Mental Development: An Epigenetic Perspective», 1979 Bibb Latane, Stephen G. Harkins, and Kipling D. Williams, «Many Hands Make Light the Work: The Causes and Consequences of Social Loafing», 1980 Gary Wayne Strong, «Information, Pattern, and Behavior: The Cognitive Biases of Four Japanese Groups», 1981 Richard A. Shweder and Edmund J. Bourne, «Does the Concept of the Person Vary Cross Culturally?»

Michael Meaney, who studies the impact of nurturing, likewise wonders what the implications of epigenetics are for social policy.

The study, published in Nature Structural and Molecular Biology, showed that a combination of genetics and epigenetics — factors that turn genes on or off — could explain how lactose intolerance develops over time.

Earlier this year, Feinberg led a study that considered this view of epigenetics in metastatic pancreatic cancer cells.

A major finding of this study is that the genetic loci associated with asthma are enriched in epigenetic marks characterizing gene enhancers.

The study results build on genetic and epigenetic basics, including that the blueprint for the human body is encoded in genes that direct the building of one or more proteins.

However, in some studies with laboratory mice, Feinberg had observed that these epigenetic tags varied considerably among the mice even when comparing the same type of tissue in animals that have been living in the exact same conditions.

Dr Tomi Pastinen, senior author on the second study, from McGill University said: «We have created an expansive, high - resolution atlas of variations that deepens our understanding of the interplay between the genetic and epigenetic machinery that drives the three primary cells of the human immune system.

Preliminary data from another study of theirs suggest that Fresno youth, by moving elsewhere to attend college, might see a reversal of some epigenetic changes to their immune cells.

The data from the study demonstrate that KZFP partner up with transposable elements to create what the authors call «a largely species - restricted layer of epigenetic regulation.»

Although I personally study epigenetics during development, evidence suggests these kind of events occur throughout life.»

«Our results indicate that the epigenetic modification we studied makes both mice and humans more susceptible to obesity and with increasing age increases their risk of developing a fatty liver,» said Anne Kammel, first author of the study.

A study published this week in PLOS Medicine suggests that epigenetic modification of the HAND2 gene plays a critical role in the development of endometrial cancer.

A case study in the epigenetic effects of upbringing in humans can be seen in the life of Szyf's and Meaney's onetime collaborator, Frances Champagne.

«Recent studies suggest that epigenetic modifications may contribute to the development of cancer progenitor cells that can induce drug resistance and the relapse of different types of cancer,» said Sibaji Sarkar, PhD, instructor of medicine at BUSM.

In a new study published in the Journal of Allergy and Clinical Immunology, researchers have now found a new principle for how epigenetic changes can occur.

Scientists from the cluster of excellence BIOSS Centre for Biological Signalling Studies at the University of Freiburg and the Freiburg University Medical Center have shown that inhibiting the epigenetic regulator KDM4 might offer a potential novel treatment option for breast cancer patients.

Up to this point, the best way to study epigenetic effects has been a strain of mice known as agouti viable yellow.

«From other studies ***** we know that epigenetic modifications of the DPP4 gene, which are associated with an increased production of the enzyme, have a negative impact on the liver metabolism already in young mice, long before fatty liver disease emerges,» says Baumeier.

Studies in cancer patients indicate reduced rates of relapse when patients are pretreated with epigenetic drugs due to its far - reaching capabilities; killing progenitor cells at the site of the tumor, in circulation, or at a distant site.

In a new study, researchers at Uppsala University have found evidence of a new principle for how epigenetic changes can occur.

That question turned out to be the basis of a new field, behavioral epigenetics, now so vibrant it has spawned dozens of studies and suggested profound new treatments to heal the brain.

«It is expected that this study will lay the foundation for developing a new class of potent and effective cancer therapies and the development of reagents targeting epigenetic events in immune - mediated diseases as well as other epigenetically - influenced diseases,» said Alani, who also is chief of dermatology at Boston Medical Center.

«Our study connects the dots between Werner syndrome and heterochromatin disorganization, outlining a molecular mechanism by which a genetic mutation leads to a general disruption of cellular processes by disrupting epigenetic regulation,» says Izpisua Belmonte.

«A general message from these studies is that cancer cells benefit from modulating epigenetic factors like SIRT6 by acquiring the ability to override normal cellular growth control patterns,» says Mostoslavsky, an associate professor of Medicine at Harvard Medical School and an associate member at the Broad Institute.

A new study suggests that epigenetic effects — chemical modifications of the human genome that alter gene activity without changing the DNA sequence — may sometimes influence sexual orientation.

In a new study published in the journal Nature Structural and Molecular Biology researchers at Karolinska Institutet in Sweden have shown that a subtle epigenetic change plays an important role in the correct segregation of chromosomes.

New findings published in the Proceedings of the National Academy of Sciences showed in lab studies that supplementing an epigenetic cancer drug called decitabine with vitamin C enhanced the drug's ability to impede cancer cell growth and trigger cellular self - destruction in cancer cell lines.

Gene Robinson, a geneticist at the University of Illinois at Urbana - Champaign, says that the paper «opens a new line of study on the role of epigenetics in controlling reproductive conflict» in bumblebees.

This is the first study to identify histone crotonylation as a driver for HIV transcription and de-crotonylation of histone as an epigenetic marker for HIV silencing.»

«This means that the epigenetic modifications are likely not caused by substances in the tobacco, but by the hundreds of different elements that are formed when the tobacco is burnt,» says Åsa Johansson, researcher at the Department of Immunology, Genetics and Pathology at Uppsala University and Uppsala Clinical Research Center, who has led the study.

Such epigenetic mechanisms are high on the list of suspects when it comes to explaining how environmental factors that affect parents can later influence their children, such as in the Dutch second world war study, but just how these epigenetic changes might be passed on to future generations is a mystery.

In addition to RNA transcripts linked with inflammation and stress, the study examines a series of epigenetic transcripts — RNA sequences that have undergone post-transcriptional modification.

Some biologists extrapolate findings from rodent studies of epigenetic inheritance to humans, but others remain skeptical