Estimation of allele frequency and association mapping using next - generation sequencing data Kim, S. Y., K. E. Lohmueller, A. Albrechtsen, Y. Li et al. 2011.
P. falciparum population genetic approaches offer promising tools for understanding transmission and spread
of the disease, but a high prevalence
of multi-clone or polygenomic infections can render
estimation of even the most basic parameters, such as
allele frequencies, challenging.