Sentences with phrase «estrone metabolite»

A diet rich in vegetable oils, white flour and sugar, exposure to pesticides and herbicides, consumption of conventionally raised dairy and meat products, the high use of plastics, as well as use of some cosmetics, toiletries and household cleaners, increases the cancer causing 16a OH Estrone metabolite.

Because of its bone - building actions, small amounts of the estrone metabolite, 16α - OH estrone (which is produced by Phase I metabolism) are required by men.

16α - OH E1, also a Phase I estrone metabolite, is an estrogen agonist, stimulates cell mitosis and proliferation, and is associated with increased risk of prostate cancer.

4 - OH estrone (4 - OH E1): An estrone metabolite that can be enzymatically oxidized to catechol estrogen quinones, which can damage DNA by forming predominantly depurinating adducts.

(1) The 2 / 16α ratio: a decrease in this ratio of the estrone metabolites, 2 - hydroxyestrone and 16α - hydroxyestrone, is associated with an increased risk of breast and cervical cancer.

Research shows that levels of the 16a OH Estrone metabolites are high in cases of breast, ovarian, cervix, uterine and other hormone - sensitive cancers.

Not exact matches

Estrogen comes in the form of three metabolites: Estrone (E1, estradiol (E2), and estriol (E3).

Estrone's oncogenic metabolites, 4 - hydroxyestrone (4 - OH estrone, considered the most carcinogenic estrogen metabolite) and 16α - OH estrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metaEstrone's oncogenic metabolites, 4 - hydroxyestrone (4 - OH estrone, considered the most carcinogenic estrogen metabolite) and 16α - OH estrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metaestrone, considered the most carcinogenic estrogen metabolite) and 16α - OH estrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metaestrone (which is needed in small amounts because of its bone - building actions), are produced by Phase I metabolism.

2 - OH E1, a Phase I metabolite of estrone, has weak estrogenic activity and is associated with protection against prostate cancer.

Originated 1970s by Dr. Henry Lemon, who tested estrogen levels in 24 hour urine samples and found that an EQ > 1 strongly correlated with a higher survival rate after breast cancer.24 Further research conducted by Lemon, Heidel, et al., a meta - analysis of published fractional estrogen excretion collected from 2,846 healthy women worldwide aged 15 to 59 years, with a risk of breast cancer varying five-fold, found that an EQ < 1 reflects increased rates of oxidation of estrone or estradiol to 4 - OH catechols (also referred to in the literature as the 3,4 - catechol estrogen quinones), which have been identified as the principal proximal human mammary carcinogens after menarche, while an EQ > 1 reflects conversion to protective 2 - OH estrogen metabolites.2526

After conversion into androstenedione, DHEA may be used to produce testosterone and its metabolites (for which reason DHEA replacement may boost libido in women) or estrone, and thus other estrogens.75

Retest with 24 - Hour Urine after 3 months to ensure sufficient 16α - OH estrone is present for bone health; run Serum Testosterone Metabolites to check 3β - adiol

Supplementation with Myomin (a combination of Chinese botanicals, 2 to 3 capsules BID63 and Chrysin (liposomal drops, 6 drops sublingually BID64, 65 will also lessen aromatase activity; however, retest with 24 - Hour Urine after 3 months to ensure sufficient 16α - OH estrone is present for bone health; run Serum Testosterone Metabolites to check 3β - adiol levels for protection against prostate cancer.

Estrone, in turn, branches out and converts into three metabolites:

To be able to safely and effectively prescribe hormone replacement therapy (BHRT or HRT) will necessitate knowing not only how much estrone, estradiol and estriol are in circulation, but how much is active (free plus conjugated [potentially active]-RRB-, and into what forms each estrogen is being metabolized: Is she predominantly producing protective or carcinogenic estrogen metabolites?

Estrone's metabolites are known to play both oncogenic and anti-oncogenic roles.

In addition, a 24 - Hour Urine test captures metabolites that are not measurable in saliva and can not be reliably measured by a single, or even multiple, blood draws, e.g., 16α - OH estrone, an estrogen metabolite shown to impact bone loss in men, and a number of glucocorticoid and mineralocorticoid metabolites (discussed in Part II of this review) that provide greater insight into long - term adrenal health, short term stress response, the cortisol / cortisone balance, and other measures of adrenal health and function than assessment of cortisol alone.

«This study demonstrates that grapefruit juice may alter the metabolic degradation of estrogens, and increase the bioavailable amounts of 17 beta - estradiol and its metabolite estrone»

Here is a fascinating data point: flaxseed does not only suppress estradiol production but it also nudges estradiol metabolism into a positive direction by generating a higher ratio of the protective metabolite 2 - hydroxy - estrone versus the more harmful 16 - hydroxy - estrone.

Ratios of estrogen metabolites (16 - OH / 2 -0 H estrone) can also be checked to identify an increased risk of breast and other cancers.