The composition of the
diet in both regimens followed the Study Group on Diabetes and Nutrition of the
European Association for the Study of Diabetes guidelines [15] with the same caloric restriction: a restriction of 2,092 kJ / day (500 kcal / day) based on the measurement of each individual's resting
energy expenditure (REE) by indirect calorimetry (metabolic monitor VMAX; SensorMedics, Anaheim, CA, USA)[16].