Additional gene duplication and divergence in eumetazoans further increased transcription
factor gene family number, which in general are 2 to 34 times larger in eumetazoans than in Amphimedon.
Not exact matches
M. J. Bertram et al., Identification of a
gene that reverses the immortal phenotype of a subset of cells and is a member of a novel
family of transcription
factor - like
genes.
«Fibroblast growth
factor receptor inhibitors are new therapies being developed in clinical trials for patients whose cancer cells have genetic alterations in this
family of
genes,» says Roychowdhury, a member of the OSUCCC — James Translational Therapeutics Program.
Unlike other autoimmune disorders with associated risk
factors, APECED is clearly caused by a mutation in a single
gene, based on analyses of affected
families.
The researchers — from the universities of Exeter, Puerto Rico and Pennsylvania — believe the cause is a mixture of their
genes and other
factors such as age, sex and
family size.
Affected
family members, the group found, had inherited one or two defective copies of ZIC3, a previously unknown
gene that appears to code for a transcription
factor — a protein that switches other
genes on or off.
A faulty
gene that causes insulin resistance may be a causative
factor in nearly half of all
families with obesity, a new study suggests.
Recent studies showed that low oxygen conditions increase levels of a
family of proteins known as HIFs, or hypoxia - inducible
factors, that turn on hundreds of
genes, including one called NANOG that instructs cells to become stem cells.
«The most intriguing of these
genes is FGFRL1, which has a cluster of amino acid substitutions unique to giraffe that are located in the part of the protein that binds fibroblast growth
factors — a
family of regulators involved in regulating many processes including embryo development,» Cavener said.
In a series of cell - based studies, they showed that it both blocked a
family of iron - containing, oxygen - sensing enzymes called hypoxia - inducible
factor prolyl - hydroxylases (HIF - PHD) and, critically, protected neurons by activating
genes that protect them from oxidative stress.
Dillin's team then screened 15 other
genes from the forkhead
family — transcriptional
factors important to development and possibly longevity, to which the
gene for daf - 16 belongs — to see if any of them were necessary to increase longevity after dietary restriction.
Specifically, this mutation, which likely occurred very early in evolution after the separation of our group from that of sea anemones, affected a
gene of the Fgfr (fibroblast growth
factor receptors)
family.
Professor Michael Lisanti, from The University of Manchester — part of Manchester Cancer Research Centre, said: «We know that high breast density can greatly increase a woman's breast cancer risk as well as other
factors such as aging,
family history and presence of mutations in
genes such as BRCA 1 and BRCA 2.
She studies how genetic
factors correlate with disease in populations, as well as looking for links between
genes and disease predisposition in
families.
They also identify
factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian - defensin
gene families.
Members of a
family that includes the apoptosis regulator APAF1 (apoptotic - protease - activating
factor 1), mammalian NOD - LRR proteins (also known as NACHT - LRR proteins or CATERPILLERs) and plant disease - resistance
gene products.
In 1984, he moved to the Institute for Molecular and Cellular Biology, at Osaka University (Osaka, Japan), where his research group continued to study the regulation of interferon
genes and discovered the interferon - regulatory -
factor family of transcription
factors.
In the absence of Wnt signaling, we found that Tcf
factors associate with proteins of the Groucho
family of transcriptional repressors to repress target
gene transcription.
According to their study, published in the current issue of the journal Cell, these
genes — from the Wnt
family — interact with another set of previously identified growth
factors to induce limb formation in chick embryos.
Activation of the UPR induces the production of a
family of basic leucine zipper - containing transcription
factors that activate transcription of
genes encoding functions to reduce the protein - folding load and increase the protein folding capacity of the ER.
The researchers found that patients from MODY3
families had one of several different mutations in the
gene for hepatocyte nuclear
factor 1 alpha (HNF -1-alpha) but healthy subjects had normal copies of the
gene.
«What we're seeing may not only be happening in limbs, but the action of these two
families of growth
factors could be very important for the genesis of a wide range of organs in the body,» said Juan Carlos Izpisúa Belmonte, a professor in the
Gene Expression Laboratory at Salk and the principal author of the Cell paper.
The presence of a cluster of aggregation -
factor - related
genes in the Amphimedon genome indicates that allorecognition could be under the control of a multigene
family.
2018-03-06 - New publication Characterization of the human RFX transcription
factor family by regulatory and target
gene analysis.
Recently, some other cytokines (such as tumor necrosis
factor) or chemical drugs were also found to up - regulate several IFN - inducible
gene family members (including RIG - G) through production of type I IFNs (37, 38), further indicating that the induction of RIG - G by ATRA in NB4 cells was tightly related with an IFNα autocrine pathway.
NPR1 Differentially Interacts with Members of the TGA / OBF
Family of Transcription
Factors That Bind an Element of the PR - 1
Gene Required for Induction by Salicylic Acid
DAXX associates with RelB, a transcription
factor of the NF - κB
family that directly controls the expression of numerous apoptosis - and autophagy - relevant
genes, including tumor suppressor protein kinases DAPK1 / 3 [1; 2].
Abbreviations: Aβ, amyloid β - peptide; AD, Alzheimer's disease; ALS, amyotrophic lateral sclerosis; Ambra1, activating molecule in Beclin -1-regulated autophagy; AMPK, AMP - activated protein kinase; APP, amyloid precursor protein; AR, androgen receptor; Atg, autophagy - related; AV, autophagic vacuole; Bcl, B - cell lymphoma; BH3, Bcl - 2 homology 3; CaMKKβ, Ca2 + - dependent protein kinase kinase β; CHMP2B, charged multivesicular body protein 2B; CMA, chaperone - mediated autophagy; 2 ′ 5 ′ ddA, 2 ′, 5 ′ - dideoxyadenosine; deptor, DEP - domain containing mTOR - interacting protein; DRPLA, dentatorubral pallidoluysian atrophy; 4E - BP1, translation initiation
factor 4E - binding protein - 1; Epac, exchange protein directly activated by cAMP; ER, endoplasmic reticulum; ERK1 / 2, extracellular - signal - regulated kinase 1/2; ESCRT, endosomal sorting complex required for transport; FAD, familial AD; FDA, U.S. Food and Drug Administration; FIP200, focal adhesion kinase
family - interacting protein of 200 kDa; FoxO3, forkhead box O3; FTD, frontotemporal dementia; FTD3, FTD linked to chromosome 3; GAP, GTPase - activating protein; GR, guanidine retinoid; GSK3, glycogen synthase kinase 3; HD, Huntington's disease; hiPSC, human induced pluripotent stem cell; hVps, mammalian vacuolar protein sorting homologue; IKK, inhibitor of nuclear
factor κB kinase; IMPase, inositol monophosphatase; IP3R, Ins (1,4,5) P3 receptor; I1R, imidazoline - 1 receptor; JNK1, c - Jun N - terminal kinase 1; LC3, light chain 3; LD, Lafora disease; L - NAME, NG - nitro - L - arginine methyl ester; LRRK2, leucine - rich repeat kinase 2; MIPS, myo - inositol -1-phosphate synthase; mLST8, mammalian lethal with SEC13 protein 8; MND, motor neuron disease; mTOR, mammalian target of rapamycin; mTORC, mTOR complex; MVB, multivesicular body; NAC, N - acetylcysteine; NBR1, neighbour of BRCA1
gene 1; NOS, nitric oxide synthase; p70S6K, ribosomal protein S6 kinase - 1; PD, Parkinson's disease; PDK1, phosphoinositide - dependent kinase 1; PE, phosphatidylethanolamine; PI3K, phosphoinositide 3 - kinase; PI3KC1a, class Ia PI3K; PI3KC3, class III PI3K; PI3KK, PI3K - related protein kinase; PINK1, PTEN - induced kinase 1; PKA, protein kinase A; PLC, phospholipase C; polyQ, polyglutamine; PS, presenilin; PTEN, phosphatase and tensin homologue deleted from chromosome 10; Rag, Ras - related GTP - binding protein; raptor, regulatory - associated protein of mTOR; Rheb, Ras homologue enriched in brain; rictor, rapamycin - insensitive companion of mTOR; SBMA, spinobulbar muscular atrophy; SCA, spinocerebellar ataxia; SLC, solute carrier; SMER, small - molecule enhancer of rapamycin; SMIR, small - molecule inhibitor of rapamycin; SNARE, N - ethylmaleimide - sensitive
factor - attachment protein receptor; SOD1, copper / zinc superoxide dismutase 1; TFEB, transcription
factor EB; TOR, target of rapamycin; TSC, tuberous sclerosis complex; ULK1, UNC -51-like kinase 1; UVRAG, UV irradiation resistance - associated
gene; VAMP, vesicle - associated membrane protein; v - ATPase, vacuolar H + - ATPase; Vps, vacuolar protein sorting
The octopus genome contains around 1,800 C2H2 zinc finger transcription
factors, the second largest
gene family so far discovered in animals (olfactory receptor
genes in elephants are the largest at around 2,000).
Other
gene families that were dramatically expanded in the octopus include zinc finger transcription
factors, which are mainly expressed in embryonic and nervous tissues and are thought to play roles in development.
17 / Jun / 2013 Although a
family history of Alzheimer's disease is a primary risk
factor for the devastating neurological disorder, mutations in only three
genes — the amyloid precursor protein and presenilins 1 and 2 — have been established as causative for inherited, early - onset Alzheimer's, accounting for about half of such cases.
Any woman who's already in a high - risk group (based on
gene mutations, a strong
family history of breast cancer, or other
factors) should have an MRI along with her yearly mammogram.
Sure I would love to loose the weight and have a Beach Body I can be proud of... but when you
factor in my Hypothyroidism and my
family «Fat»
genes... I'm stuck!
The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a member of the
family of transcription
factors that regulate the expression of
genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....
The greatest risk
factors for Alzheimer's are older age, having a
family history of Alzheimer's and carrying the APOE - e4
gene.»
Genes,
family, environment, and many other
factors determine how much each of us eats.
A
gene family that is involved in development, the zinc - finger transcription
factors, is also highly expanded in octopuses.
The second problem is that the environmental
factors examined in the studies usually cited as evidence for
gene - environment interactions — for example, high
family conflict (Bergeman, Plomin, McClearn, Pedersen, & Friberg, 1988), low socioeconomic status (Cloninger, Sigvardsson, Bohman, & von Knorring, 1982), or criminal parents (Mednick, Gabrielli, & Hutchings, 1987)-- can not account for differences between siblings reared together.
STAT6 is part of the STAT
family of transcription
factors, its phosphorylation in response to cytokines and growth
factors activates the transcription of many
genes involved in the immune system such as interleukin 4 (IL - 4).
Although an interaction was established between the type of care (institutional vs.
family) and genetic moderation
factors, with a protective
factor of the 5HTT / allele genotype for high scores on attachment disorganisation in institutionalized children, the authors noted that it is not clear if genetic
factors can protect some children in adverse environments or if the experience of being raised in these environments can alter the expression of the
gene.