Sentences with phrase «fanconi anaemia»

Defective DNA repair is known to activate p53, but our results indicate that, conversely, an increased p53 activity may attenuate the Fanconi anaemia DNA repair pathway, defining a positive regulatory feedback loop.»

Furthermore, p53Δ31 / Δ31 fibroblasts exhibit a reduced capacity to repair DNA interstrand crosslinks, a typical feature of Fanconi anaemia cells.

Here we show that these cells exhibit decreased mRNA levels for additional genes contributing to telomere metabolism, but also, surprisingly, for 12 genes mutated in Fanconi anaemia.

So Izpisúa Belmonte and his colleagues harvested fibroblasts, which are far more common than stem cells, from the skin of people with the bone marrow disease Fanconi anaemia.