Sentences with phrase «finding tumour cells»

Not exact matches

We also detected circulating tumour cells, which were found in higher numbers in patients who had received more prior therapies.

«Recent data have shown that a variant of the androgen receptor called AR - V7, found in tumour cells circulating in the blood of patients with metastatic CRPC, predicted resistance to treatment with enzalutamide and abiraterone,» she will say.

Injections of killed stem cells, designed to help the immune system recognise cancers, have been found to protect mice from developing tumours

Within 24 hours, the team found that H. pylori was causing the organoid cells to divide twice as fast as normal, and activating a particular gene, c - Met, that can cause tumours.

They found 60 per cent fewer blood vessels surrounding tumour - like tissue grown from Down's stem cells than those from other volunteers.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

High levels of the protein were also found in cultures of metastatic cells from tumours of the colon, breast, head and neck.

«Pancreatic cancer is extremely hard to treat by chemotherapy, so this finding is important because vitamin A targets the non-cancerous tissue and makes the existing chemotherapy more effective, killing the cancer cells and shrinking tumours.

Mutations that occur in the first malignant cells, those in the trunk of this evolutionary tree, will end up in all the tumour cells; mutations that arise later will be found only in the tree's branches.

Most researchers assumed that this is because a few rogue cancer cells find ways to circumvent the drugs before the whole tumour has been killed off.

Germ cells can develop into tumours — both benign and malignant — particularly in the testes or ovaries, where the cells are normally found.

Ironically, TRAIL normally delivers a signal for cells to die, but the Trinity scientists found that this molecule can also send a wound - healing message from tumour cells.

In research funded by Sparks charity, Great Ormond Street Hospital Children's Charity and Cancer Research UK, researchers at the University of Cambridge have developed a test for blood and cerebrospinal fluid samples that looks for a specific panel of four pieces of short genetic code known as microRNAs, which are found in greater quantities in malignant germ cell tumours.

The researchers found five different sub-types of HL among the patients studied: 247 cases of the nodular sclerosis (NS) type, in which the tumour nodules are large; 105 of mixed cellularity, where a mixture of different types of inflammatory cells are involved; 58 lymphocyte rich, the sub-type with the best outcome; 68 «others»; and 143 «not otherwise specified» (NOS).

The team used five types of antibiotics — including one used to treat acne (doxycycline)-- on cell lines of eight different types of tumour and found that four of them eradicated the cancer stem cells in every test.

Dr Sophie Roerink, joint first author from the Wellcome Sanger Institute, said: «We found mutational processes in these cancer cells that are just not seen in normal cells, leading to a huge increase in mutation rate for tumours compared with normal cells.

The research team with international collaborators analysed more than 100 patient samples from ovarian and other cancer types to discover a distinct population of cells found in some tumours.

Breast cancer cells that spread to other parts of the body break off and leave the primary tumour at late stages of disease development, scientists from the Wellcome Trust Sanger Institute and their collaborators have found.

The team found that most of the genetic changes in the original breast tumour were also present in the metastatic tumours, showing that the cancer cells spread late in disease development.

Reporting their laboratory findings in the journal Aging, the team observed that addition of DPI to a mixed population of cells eliminated the tumour initiating cancer stem cells.

«The cells in each tumour are finding a different way to do that,» Saunders says.

The existence of cancer stem cells has already been reported in a number of human cancers, explains Professor Jacobsen, but previous findings have remained controversial since the lab tests used to establish the identity of cancer stem cells have been shown to be unreliable and, in any case, do not reflect the «real situation» in an intact tumour in a patient.

Therefore, «this finding may represent a future therapeutic strategic to combine with other strategies, such as immunotherapy, chemotherapy or inhibitors against specific signalling routes of the tumour cells.»

However, examining OS tumours the research team behind the new results found that OS cancer cells express special enzymes and receptors, enabling them to degrade bone tissue themselves.

A team working at the Institute of Cancer Research and the Royal Marsden Hospital in London, in collaboration with scientists at the National Cancer Institute in Bethesda, Maryland, has found that tamoxifen also works by encouraging the cells surrounding a tumour to produce a «growth factor».

They found that the drug increased the level of lactate in cells and, more importantly, reduced tumour growth.

One finding was that a cell signal pathway called Wingless and its central signal molecule, beta - catenin, can regulate the production of MGMT in the tumour cell.

Using a CRISPR - dCas9 epigenetic editing tool, the researchers methylated different genes in healthy breast cells and found that those changes were sufficient to cause the cells to undergo «hyperproliferation» — abnormally rapid cell division which is an early stage of tumour initiation.

Mutations in a gene that helps regulate when genes are switched on and off in cells have been found to cause rare cases of Wilms tumour, the most common kidney cancer occurring in children.

Brain cells are often found in ovarian teratomas, but it is extremely unusual for them to organise themselves into brain - like structures, says Masayuki Shintaku at the Shiga Medical Centre for Adults in Japan, who studied the tumour.

They found that some important cancer - associated mutations were present in all cells from one region of a tumour, but undetectable in another.

For these cells to be as useful as embryonic stem cells, «we have to find a way to avoid retroviruses before application in cell therapy», Yamanaka says, as they could result in tumours.

*** It is directed against the 5T4 / WAIF1 tumour antigen, a protein found on many different solid tumours and is thought to contribute to the spread of cancer cells.

Combining a cancer therapy with a second drug therapy that helps suppress tumour blood vessels found in cancer cells can help to significantly reduce the spread of breast cancer tumours while also causing cancer cell death.

We target tumours by exploring how the proteins found on the cancer cell surface can be utilised to inhibit growth or kill tumours.

They thus confirmed their hypothesis: the integration of viral DNA was found more often in tumour cells than in healthy cells in these 11 patients.

This makes it much easier to find out who they bind to, where they are localised, and what their levels of expression are — all in the patient derived tumour cells.

The enzyme that degrades these chains is called heparanase, and the researchers found that medulloblastoma cells, as well as cells from other childhood brain tumours, need this enzyme, which may suggest new ways to treat the tumor.

The researchers found much higher levels of heparanase in childhood brain tumours than in the normal brain, and furthermore, a molecule that can block this enzyme induces cell death in medulloblastoma cells in culture, while normal brain cells were not affected.

In both early stage non-small cell lung cancer and limited stage small cell lung cancer, we found evidence of a significant association between continued smoking and recurrence of the primary tumour; in limited stage small cell lung cancer, we found also evidence of a substantial elevation in the incidence of a second primary tumour.

Scientists looked at tumour samples and found that the drug penetrates the core of the tumour as well as the surrounding areas which contain smaller numbers of cancerous cells.

Our scientists have made vital contributions to finding new and better ways to diagnose and treat brain and nerve cell tumours.

This new research, conducted by scientists in Belgium and published in the journal Nature Communications, found that in yeast, the presence of high levels of glucose (sugar) can activate a gene called Ras — the role of which is to regulate cell generation, both in mammals and in yeast — which is often found in tumours.

The Journal of Agricultural and Food Chemistry had on its December 2006 issue a report that found the ability of red raspberries to repress the human oral and breast, as well as colon and prostate tumour cell lines growths when they were tested in test tubes.

In a study done by scientists at Canada's British Columbia Cancer Research Centre, it was found that mice fed on a high - protein, low - carbohydrate diet had slower tumour cell growth than those fed a typical Western diet high in carbohydrates.