«Specific Brain Protein Required
For Nerve Cell Connections To Form And Function.»
Not exact matches
Scientists have discovered why a single mutated protein can lead to serious mental retardation in men with a common genetic disorder called fragile - X syndrome: The healthy protein is essential
for establishing during childhood the adult pattern of
connections between
nerve cells in the brain.
For the first time, stem
cell researchers have succeeded in getting transplanted
nerve cells to establish
connections with other neurons to improve movement in paralyzed rats.
Writing in 2014 in the European Journal of Neuroscience, Leuner and colleagues reported that in rats with symptoms of postpartum depression (induced by stress during pregnancy, a major risk factor
for postpartum depression in women),
nerve cells in the nucleus accumbens atrophied and showed fewer protrusions called dendritic spines — suggesting weaker
connections to surrounding
nerve cells compared with healthy rats.
For a damaged
nerve to regain function, its long, signal - transmitting extensions known as axons need to grow and establish new
connections to other
cells.
«This study suggests that amyloid deposition in the gray matter affects the associated white matter
connections, which are essential
for conducting messages across the billions of
nerve cells in the brain, allowing
for all aspects of mental function.»
He and his collaborators were able to show,
for example, that during swimming, motor signals move down the body through muscle
cells themselves as well as through
nerve connections, by selectively blocking sections of its musculature and nervous system.
It may,
for example, partly account
for the differences in brain structure and behavior between identical twins, and could even affect thought processes by subtly influencing the changes in
nerve cell connections that occur with experience.
How that might eventually predispose a person to Alzheimer's is still unclear, but it may involve a receptor molecule
for the herpes virus in the
connections between
nerve cells.
Understanding the biochemical processes that are important
for maintaining these
connections may help address the abnormalities in
nerve cells that occur in these disease states.
«Since cholesterol is required by neurons to form synapses (
connections) with other
cells, this decrease in cholesterol could affect how
nerves function
for appetite regulation, behavior, memory and even pain and motor activity,» says Dr. Kahn, who is also Mary K. Iacocca Professor of Medicine at Harvard Medical School.
In bench assays using living
nerve cells to monitor new neuronal
connections, Harding, Wright and their colleagues found Dihexa to be seven orders of magnitude more powerful than BDNF, which has yet to be effectively developed
for therapeutic use.
We know,
for instance, quite precisely which receptors in the brain are responsible
for changes in the functional
connections between
nerve cells, the synapses; we also know the rules, when synapses get stronger and when they get weaker.
The researchers discovered that nicotine uses a mechanism responsible
for learning and memory to enhance the
connections between one set of
nerve cells that are sensitive to the drug and other
nerve cells that register pleasure.
As with stroke, CNB - 001 was again discovered to maintain the critical signalling pathways needed
for nerve cell survival, and also the
connections between
nerve cells which are lost with the injury.
Now we are beginning to see that glial
cells «go rogue» and begin — unexplainably — to destroy
nerve connections that are healthy, even essential
for the brain's function.
Studies show that nitric oxide signaling and the blood flow increases it stimulates play a central role in
nerve cell maintenance, growth and repair.,, Most pertinent to anyone looking to enhance their aptitude
for learning, nitric oxide - induced blood flow also makes forming new memories physically possible as it plays a key role in what neurologists call long - term potentiation, a process required
for assembling and reinforcing new synaptic
connections throughout the entire cerebral cortex, striatum, and hippocampus.