Sentences with phrase «foxp3 expressing cells»
FoxP3 expressing cells that were CD4 + were readily detected in tolerant allografts (Figures 7c — e).
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Furthermore, the laboratory is actively investigating how the interaction of IL - 10 with the IL -10-receptor expressed on regulatory T cells controls Foxp3 expression and Treg function.
[i] Soon after, two papers, by Alexander Rudensky [ii] and by Roli Khattri and Fred Ramsdell, [iii] report in Nature Immunology that Foxp3 is expressed by CD4 + CD25 + regulatory T cells and programs their development and function.
CD4 + regulatory T (Treg) cells expressing the forkhead box transcription factor Foxp3 have a vital function in the maintenance of immune homeostasis and the prevention of fatal multi-organ autoimmunity throughout life.
(B) Representative percentage of donor - derived spleen T cells expressing Foxp3 on days 7, 14, and 28.
In the tolerant allograft, FoxP3 + cells (C) and CD4 + (D) cells were detected, which overlapped when merged (E) suggesting that the CD4 + cells expressed FoxP3.
In contrast, none of the syngeneic or rejected allografts showed any FoxP3 - expressing cells, as reflected by the merged stains of both FoxP3 and CD4 stains in F and G, respectively.
To detect regulatory T cells, we co-stained our sections by immunofluorescence for FoxP3 and CD4 - expressing cells.