From cytogenetic research to genome - wide copy number association from micro-arrays, SVS delivers a powerful toolset for correlating common and rare chromosomal aberrations with disease.
Strains available only
from the cytogenetics and Down syndrome models repository are listed in the table below.
Not exact matches
Geneticists passed
from the formal genetics of individuals to
cytogenetics at the cellular level, to the biochemistry of DNA in duplication and in protein synthesis at the molecular level, back to physiological and developmental genetics again at the cellular level and back to the level of the individual in behavioral genetics and beyond the individual to population genetics and the theory of evolution.
The scientists, including Florian Reisinger
from the Institute of Virology (HMGU) and Dr. Kristian Unger
from the Research Unit Radiation
Cytogenetics (HMGU) showed this using mouse models.
This approach is now being used to derive embryonic stem cells
from a variety of strains including disease models
from which in vitro tools are in demand, including mouse models of Alzheimer's disease,
cytogenetic disorders (Turner's syndrome and Down syndrome), and tool strains for systems genetics.
Immunohistochemical,
cytogenetic and genetic analyses were performed on both the human biopsy and xenografted tumor
from severe combined immunodeficient mice.
Those with uninformative
cytogenetic or molecular markers with negative minimal residual disease at the end of induction were noted to experience the most benefit (nearly 2-fold benefit
from receiving a fifth dose of chemotherapy) vs. those with favorable
cytogenetic and molecular features who did not experience benefit
from receiving a fifth dose of therapy.