Sentences with phrase «further clinical trials of»

He is contemplating a return to medicine, he says, but for now he takes satisfaction in corresponding with addiction researchers from his Paris apartment and encouraging them to conduct further clinical trials of baclofen.

«If it doesn't show any improvement, then I doubt there will be any further clinical trials of it.»

Not exact matches

A surge of call centers opening in India, increasing clinical trials being conducted in Eastern Europe, and increased manufacturing throughout the Far East.

These risks and uncertainties include: Gilead's ability to achieve its anticipated full year 2018 financial results; Gilead's ability to sustain growth in revenues for its antiviral and other programs; the risk that private and public payers may be reluctant to provide, or continue to provide, coverage or reimbursement for new products, including Vosevi, Yescarta, Epclusa, Harvoni, Genvoya, Odefsey, Descovy, Biktarvy and Vemlidy ®; austerity measures in European countries that may increase the amount of discount required on Gilead's products; an increase in discounts, chargebacks and rebates due to ongoing contracts and future negotiations with commercial and government payers; a larger than anticipated shift in payer mix to more highly discounted payer segments and geographic regions and decreases in treatment duration; availability of funding for state AIDS Drug Assistance Programs (ADAPs); continued fluctuations in ADAP purchases driven by federal and state grant cycles which may not mirror patient demand and may cause fluctuations in Gilead's earnings; market share and price erosion caused by the introduction of generic versions of Viread and Truvada, an uncertain global macroeconomic environment; and potential amendments to the Affordable Care Act or other government action that could have the effect of lowering prices or reducing the number of insured patients; the possibility of unfavorable results from clinical trials involving investigational compounds; Gilead's ability to initiate clinical trials in its currently anticipated timeframes; the levels of inventory held by wholesalers and retailers which may cause fluctuations in Gilead's earnings; Kite's ability to develop and commercialize cell therapies utilizing the zinc finger nuclease technology platform and realize the benefits of the Sangamo partnership; Gilead's ability to submit new drug applications for new product candidates in the timelines currently anticipated; Gilead's ability to receive regulatory approvals in a timely manner or at all, for new and current products, including Biktarvy; Gilead's ability to successfully commercialize its products, including Biktarvy; the risk that physicians and patients may not see advantages of these products over other therapies and may therefore be reluctant to prescribe the products; Gilead's ability to successfully develop its hematology / oncology and inflammation / respiratory programs; safety and efficacy data from clinical studies may not warrant further development of Gilead's product candidates, including GS - 9620 and Yescarta in combination with Pfizer's utomilumab; Gilead's ability to pay dividends or complete its share repurchase program due to changes in its stock price, corporate or other market conditions; fluctuations in the foreign exchange rate of the U.S. dollar that may cause an unfavorable foreign currency exchange impact on Gilead's future revenues and pre-tax earnings; and other risks identified from time to time in Gilead's reports filed with the U.S. Securities and Exchange Commission (the SEC).

If we are required by the FDA, the EMA, or other regulatory authorities to perform studies in addition to those we currently anticipate, or if there are any delays in completing our clinical trials or the development of our current product candidates, our expenses could increase and our ability to generate revenue could be further delayed.

A day after Collins was heard off the House floor discussing the possible sale of an Australian biotech stock, the company issued a news release further confirming its experimental treatment for multiple sclerosis had failed in clinical trials.

WASHINGTON — A day after Rep. Chris Collins was heard off the House floor discussing the possible sale of an Australian biotech stock, the company issued a news released further confirming its experimental treatment for multiple sclerosis had failed in clinical trials.

Researchers have not yet determined which of these components, or if the combination of all of them, may offer protection against inflammation, but Bao and her colleagues are interested in exploring this further through clinical trials that would regulate and monitor diet.

But billions of dollars have poured into large - scale clinical trials of amyloid - lowering therapies that so far have failed.

Dr. Del Maestro adds, «Yong and colleagues at the University of Calgary have begun to unravel the complex interaction of the microglia with the brain tumor cells, resulting not only in furthering our understanding, but providing a new concept and drug which can now be immediately assessed in clinical trials.»

Their results, published this week in the journal Biomedical Optics Express, from The Optical Society (OSA), may yield a cheaper and less invasive initial screening test for colon cancer that could complement colonoscopy, though further clinical trials will need to demonstrate the safety and effectiveness of the blood test before it is routinely used.

Thus far, such side effects seen in clinical trials have been minor, but it sometimes takes years of exposure to a drug before deadly infections show up, he says.

«This vaccine appears to be safe for patients, and elicits a broad anti-tumor immunity — we think it warrants further testing in larger clinical trials,» said study lead author Janos L. Tanyi, MD, an assistant professor of obstetrics and gynecology at Penn Medicine.

Previous research has largely focused on dietary components and which diet would be best to lower the risk of obesity and type 2 diabetes, but so far there is no clear evidence from epidemiological or clinical trial data that a specific diet is optimal for long - term weight - loss or lowering the risk of diabetes.

In collaboration with Ghent University Hospital and Antwerp University Hospital, VIB and Ghent University are now planning clinical trials to further validate immunodiagnosis of FMF.

... The results support the rationale for further randomized clinical trials of AHSCT for the treatment of MS,» the article concludes.

One aspect to the pandemic has, so far, gone as planned: clinical trials of the new vaccines.

This small molecule is in clinical trials against cancer and has high specificity and good pharmacological properties, which could warrant its further development as antiviral drug for treatment of pH1N1 virus infection,» Dr. Oxana Denisova says.

These findings provide further evidence of ONC201 as an inhibitor of cancer stem cells and support ongoing clinical trials in prostate cancer and glioblastoma that have shown evidence of tumor shrinkage.

The most prominent example so far is the drug sti571, known as Gleevec, which in a recent clinical trial put an amazing 53 out of 54 patients with chronic myelogenous leukemia into remission.

Work done so far suggests that the technique — a modified form of IVF — is safe enough to try in clinical trials, the HFEA panel said, as long as several extra experiments are carried out first and children born as a result of the technique are followed up for an extensive period.

* GRAIL plans to use the money to further develop the technology and to run the large clinical trials (involving hundreds of thousands of subjects) needed to see if screening will be feasible.

Despite expectations of a rapid breakthrough, no cystic fibrosis gene therapy trial so far has been able to show long - term clinical improvement.

«Secondary benefits of this trial include the significant improvement in clinical care for children with sickle cell disease at each of the 29 sites because each location had a designated hematologist, neurologist, neuroradiologist and psychologist working as a team to identify and decrease further injury to the brain in this vulnerable population.»

This was the situation for the 14 arm amputees who took part in the first clinical trial of a new treatment, invented by Chalmers researcher Max Ortiz Catalan, and further developed with his multidisciplinary team in the past years.

A 38 - center clinical trial sponsored by the National Institutes of Health and led by researchers at the Stanford University School of Medicine has shown that far more people than previously thought can benefit from an emergency procedure for acute ischemic stroke.

When asked about the ethics of offering a drug to people who may never get the disease it's designed to prevent, Michael Sand, the Boehringer scientist overseeing the clinical trial, acknowledges that psychosis risk prediction is far from perfect.

Further clinical trials are on - going internationally, and we hope to include data from them in a future analysis to determine whether the promise of today's results is confirmed in an even larger and more diverse group of patients.»

The study is investigator led and has therefore focused on clinical need, targeting patients with progressive multiple sclerosis in whom most disability is incurred... The study also reports a predominant effect on neurodegenerative rather than inflammatory outcomes, suggesting a novel mechanism of action that might be suitable as combination treatment with immunomodulatory treatments... Further phase 3 studies to measure the effect of simvastatin on sustained disability, particularly in patients with non-relapsing secondary progressive and primary progressive multiple sclerosis, are clearly needed, but this trial represents a promising point from which to develop trials of progressive disease.»

However, the authors stress that «further clinical investigations will be essential to establish the optimal dose, duration and safety, and whether vitamin D2 or D3 have different effects on mortality risk, since the available trials are based on elderly populations in general (an age group with high competing risk of death often due to multiple co-existing disease conditions) and they do not typically include cause - specific deaths as the primary outcomes.»

Watterson and his collaborators have a new National Institutes of Health (NIH) award to further refine the compound so it is metabolically stable and safe for use in humans and develop it to the point of starting a phase 1 clinical trial.

«The team will further evaluate the long - term biocompatibility of the modified insulin system in an animal model before determining whether to move to clinical trials,» says co-author Dr. John Buse, professor of medicine at the UNC School of Medicine and director of the UNC Diabetes Care Center and the NC Translational and Clinical Sciences Inclinical trials,» says co-author Dr. John Buse, professor of medicine at the UNC School of Medicine and director of the UNC Diabetes Care Center and the NC Translational and Clinical Sciences InClinical Sciences Institute.

If these preclinical studies are successful, the researchers plan to further develop their CAR T cell therapy and test its safety and efficacy for different types of metastatic cancer in upcoming clinical trials.

Looking further ahead the research will expand to include animal testing and then a series of clinical trials in humans.

Further study in clinical trials is necessary, but the study provides a promising new find in a type of cancer with no current targeted options, Chan said.

In a small phase I and II clinical trial, Johns Hopkins researchers and colleagues elsewhere found that the high - fat, low - carbohydrate ketogenic diet was a safe and effective treatment option for the majority of adults experiencing a relatively rare, often fatal and always severe form of epilepsy marked by prolonged seizures that require medically induced comas to prevent them from further damaging the body and the brain.

«We can reduce the toxicity of approved protein drugs, and may also be able to rehabilitate protein fusion drugs that have so far failed in clinical trials due to unacceptable side effects.»

«The clinical trials for treatments have all failed because by the time of diagnosis the brain is so far gone that it's like pouring gas into a car that has no engine.»

Dr. Younossi stressed that while these preliminary results are encouraging, he plans to conduct further research to examine data outside of the clinical trial setting in order to evaluate the real - world consequences of a hepatitis C cure on work productivity and associated economic gains.

Melton and his colleagues are already working with Evotec, a company in Hamburg, Germany, and Janssen Pharmaceuticals, a subsidiary of Johnson & Johnson, to further study betatrophin and possibly move it toward clinical trials.

Scientific knowledge and new findings go far beyond data sets produced from clinical trials, often are outside the scope of the parameters established by the Food and Drug Administration regulations, and often outdate the FDA - approved labeling.»

«Despite the limitations of a single arm, non-randomized study, we infer from these data that Interferon ß - 1a treatment is worth further consideration for the treatment of Ebola virus disease,» said Dr. Fish, who is also a Professor in the Department of Immunology at the University of Toronto, noting that the decision to undertake the clinical trial was based on previous preliminary scientific data, and on the fact that no currently approved antivirals exist to treat Ebola.

Of the five studies the project has tackled so far, some involving experimental treatments already in clinical trials, only two could be repeated; one could not, and technical problems stymied the remaining two replication efforts.

Moreover, our previous study found that regular use of aspirin after diagnosis was associated with longer survival among the 15 % to 30 % of patients with colorectal cancer and with a mutation in phosphatidylinositol -4,5-bisphosphate 3 - kinase, catalytic subunit alpha (PIK3CA [NCBI Entrez Gene 5290]-RRB-, one of the PI3K family genes.30 Markedly improved survival associated with aspirin according to PIK3CA status was also found in an analysis within a separate clinical trial cohort.31 Further investigations for the joint effect of these genes would be helpful to better understand the underlying molecular mechanisms of aspirin, NSAIDs, and colorectal cancer.

«This clinical trial utilizes some of the best aspects of what we've learned so far with chemotherapy and radiation,» says Gregory Gan, MD, PhD.

So clinical trials are certainly something that are still far away at the current stage, but it is certainly worthwhile to follow our experimental approach both in vitro and in vivo, in order to test whether at some stage we can really move forward and test, whether by reprogramming endogenous cells, we can reconstitute neural circuits that are damaged or deceased; and, thereby also improve the lives of many people that suffer neurological diseases.

Of course, we are still far away from being able to do this within the context of a clinical trial in humanOf course, we are still far away from being able to do this within the context of a clinical trial in humanof a clinical trial in humans.

There is no further news on advancement of clinical trial although phase I / II trial has been completed in 2008.

This paper provides direct evidence for the role of TNF in chronic intestinal inflammation using TNBS colitis in Tg197 mice as a model and encourages further clinical trials with anti-TNF therapeutics for the treatment of Crohn's disease.

In an effort to further exploit the potential of Pexa - Vec to activate the immune system to fight cancer, as seen in McDonald's preclinical data, SillaJen recently announced a new clinical trial in collaboration with New York - based Regeneron Inc. to test Pexa - Vec and REGN2810, a PD - 1 checkpoint inhibitor, in combination against renal cell carcinoma, and recently signed a sponsored research agreement with UCSF to enable joint support of parallel preclinical experiments by McDonald's team.