Sentences with phrase «g protein beta»

G protein beta gamma subunits have been found to have regulatory effects on certain types of adenylyl cyclase.

Not exact matches

In the presence of Gs alpha, the alpha subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by beta gamma, some forms were activated by beta gamma, and some forms were not affected by beta gamma.

Heterotrimeric guanine nucleotide - binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)- bound alpha subunits and a complex of beta and gamma subunits after interaction with receptors.

For the study, the Bohn worked closely with TSRI chemist Thomas Bannister, PhD, to develope new potential drug molecules; they then tweaked their chemical structures to systematically vary the «bias» between the two pathways — G protein signaling and beta - arrestin recruitment.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

The researchers wanted to activate one typical response — G protein signaling — while not activating something called the beta - arrestin2 pathway.

Meanwhile, a drug that works much the same way — by blocking the beta - arrestin2 pathway while activating the G protein pathway at the mu opioid receptor — is currently in the final stages of human clinical trials.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

When the adrenal gland produces adrenaline and the adrenaline (beta - adrenergic) receptor communicates with the G - protein and its signal cascade, the parts of the body are alerted to the need for action; the heart beats faster, the blood flow to the gut decreases while the blood flow to the muscles increases and the production of glucose is stimulated.

Per serving (3/4 cup): calories: 135; fat: 2.6 g; saturated fat: 0.4 g; calories from fat: 17.3 %; cholesterol: 0 mg; protein: 5.8 g; carbohydrates: 24.4 g; sugar: 13.1 g; fiber: 3.3 g; sodium: 85 mg; calcium: 188 mg; iron: 1.8 mg; vitamin C: 3.7 mg; beta - carotene: 11 mcg; vitamin E: 2 mg

Organic milk in LP had higher concentrations of beneficial whey proteins than conventional milk, including beta - lactoglobulin (beta - Lg, 4.12 vs. 2.68 g L - 1), lactoferrin (Lf, 334.99 vs. 188.02 mg L - 1), and lysozyme (Lz, 15.68 vs. 12.56 mu g L - 1).

Nutrition Per Serving (1 cup): 124 calories; 0.3 g fat; 0.1 g saturated fat; 2.2 % calories from fat; 0 mg cholesterol; 2.7 g protein; 28.8 g carbohydrates; 4.8 g sugar; 4 g fiber; 307 mg sodium; 40 mg calcium; 2.6 mg Iron; 59.3 mg vitamin C; 458 mcg beta carotine; 0.4 mg vitamin E

Nutrition Per Serving: 47 calories; 0.3 g fat; 0.1 g saturated fat; 5.3 % calories from fat; 0 mg cholesterol; 1.5 g protein; 11.4 g carbohydrates; 5.2 g sugar; 2.8 g fiber; 124 mg sodium; 21 mg calcium; 0.7 mg iron; 19.5 mg vitamin C; 293 mcg Beta Carotene; 0.5 mg vitamin E

Nutrition per serving (1/4 of recipe): 49 calories; 0.7 g fat; 0.1 g saturated fat; 12.2 % calories from fat; 0 mg cholesterol; 2.5 g protein; 10.1 g carbohydrates; 4.9 g sugar; 5 g fiber; 3 mg sodium; 27 mg calcium; 0.8 mg iron; 35.4 mg vitamin C; 282 mcg beta carotene; 1.3 mg vitamin E

Amount per serving: Calories 50 Calories from Fat 10 Total Fat 1 g Saturated Fat 0.2 g Sodium 60 mg Total Carbohydrates 8 g Dietary Fiber 4 g Sugars 2 g Protein 4 g Vitamin A (75 % as Beta - Carotene) 10,000 IU Vitamin C (as Calcium Ascorbate) 960 mg Calcium (as Ascorbate, Citrate, Gluconate, Pantothenate) 270 mg Iron 2 mg Vitamin D3 125 IU Vitamin E (as Mixed Tocopherols) 50 IU Thiamin (Vitamin B1) 11.5 mg Riboflavin (Vitamin B2) 11.5 mg Niacin (97 % as Niacinamide) 155 mg Vitamin B6 12.5 mg Folic Acid 100 mcg Vitamin B12 200 mcg Biotin 200 mcg Pantothenic Acid 150 mg Iodine (as Potassium Iodide) 50 mcg Magnesium (as Magnesium Citrate / Glycinate) 75 mg Zinc (as Zinc Arginate) 15 mg Selenium (as Sodium Selenite) 100 mcg Copper (as Copper Glycinate) 1 mg Manganese (as Manganese Picolinate) 1.2 mg Chromium (as Chromium Picolinate) 100 mcg Molybdenum (as Sodium Molybdate) 125 mcg Potassium (as Potassium Aspartate / Iodide) 50 mg Alpha - Carotene 5 mg Lycopene 1.5 mg Inositol Hexaphosphate 175 mg Choline 63 mg Germanium Sesquioxide 50 mg Glutathione (reduced) 175 mg L - Carnitine 100 mg Glycine 250 mg Lactoferrin 50 mg Taurine 125 mg Grape Seed Extract 50 mg Fish Oil Concentrate 125 mg Methylsulfonylmethane 100 mg Borage Oil (20 % GLA) 112.5 mg Tocotrienols 25 mg Coenzyme Q10 75 mg Bioflavonoid Complex 50 mg Trimethylglycine 250 mg Quercetin 250 mg Artemisia annua extract 4:1 100 mg Beta -1,3-Glucan 50 mg Green Tea Extract (40 % Catechin) 50 mg Mushroom Extract 1.5 g Bromelain 163 mg Turmeric (95 % Curcumin) 100 mg Panax Ginseng 50 mg Milk Thistle Extract (80 % Silymarin) 30 mg Olive Leaf Extract (10 % Oleuropein) 100 mg Astragalus 50 mg Lipoic Acid 20 mg

Nutrition per serving (1 cup): 166 calories; 1.7 g fat; 0.2 g saturated fat; 9.3 % calories from fat; 0 mg cholesterol; 2.2 g protein; 34.8 g carbohydrates; 0.8 g sugar; 2.6 g fiber; 226 mg sodium; 42 mg calcium; 1 mg iron; 4.1 mg vitamin C; 606 mcg beta - carotene; 0.1 mg vitamin E