Sentences with phrase «g protein coupled»

One began when University of Michigan biochemist Roger Sunahara and Stanford researcher Brian Kobilka asked Skiniotis to help characterize the structure of an activated G protein coupled receptor (GPCR) bound to a G protein trimer, a central signaling complex involved in all aspects of human physiology.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

Dr. Conklin pioneered the field of using designer G protein coupled receptors (RASSLs) for tissue engineering.

This in vivo reconstitution system provides a new approach for examining ligand binding and G protein coupling to cell surface receptors.

Not exact matches

Tip # 3: I've also made this with vegan sausage which would make it more of a meal than a side dish and it would add significant protein (26 g in one link), but decided to make it optional for a couple of reasons.

Our current research involves the study of a G - protein coupled receptor by single - molecule detection methods.

In the study, «Succinate and its G - protein - coupled receptor stimulate osteoclastogenesis,» the researchers took samples of bone marrow from hyperglycemic male mice and healthy mice.

The largest class of human target proteins for drugs are the so - called G - protein - coupled receptors.

The β2 - adrenergic receptor (β2AR) is a well - studied prototype for heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors (GPCRs) that respond to diffusible hormones and neurotransmitters.

Physicist Marshall Stoneham and his colleagues at University College London report they have constructed a specific mechanism based on the properties of so - called G - protein coupled receptors, which project from olfactory cells inside the nose.

When the researchers then administered acetylcholine to the mice through the nebulizer, they observed that mice with the G protein - coupled receptors reacted more vigorously than those with only smooth muscle reactions, and they also showed increased airway restriction compared to their counterparts without the receptor.

To explore the effects of the receptor on the airway, the researchers used a protein called BAM8 - 22, which is an itch activator that specifically targets the G protein - coupled receptor, to induce a reaction.

In a report on the study, published Feb. 5 in Nature Neuroscience, researchers say the biochemical receptor, known as a G protein - coupled receptor, was present on nerve cells in the lower respiratory tracts of lab mice.

The research team then infected specially bred mice carrying G protein - coupled receptors and those without the receptor with an influenza virus — which is known to trigger asthma attacks in humans.

To acquire new insights into the biology and possible therapy of these tumors, Feigin et al. looked for aberrant expression of G protein — coupled receptors, cell signaling proteins that have been successfully targeted for treatment of other disorders such as depression.

They found that stimulation of the G protein - coupled receptor increased airway constriction more than activating the airway smooth muscles alone.

The molecule is known as a G protein - coupled receptor because it triggers so - called G proteins to bind to the inner side of a receptor and start a signal cascade.

«Now it is time to start making a serious impact on the field of structural biology of G protein - coupled receptors and other challenging membrane proteins and complexes.

The new study illustrated an innovative technique to find structural details about G protein - coupled receptors (GPCRs), which are targeted by approximately 40 percent of modern medicines.

The serotonin receptor belongs to a large group called G protein - coupled receptors, or GPCRs.

The ability to track markers inside and outside a cell simultaneously, and to map them atop images showing the cell's shape, is also helping researchers study the metabolic effects of signaling molecules, such as G - protein - coupled receptors.

Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body's hard - working G protein - coupled receptors (GPCRs) than previously thought, suggesting a conceptual advance in the fields of biochemistry and pharmacology.

The sequence of the 5HTlc receptor reveals that it belongs to the family of G protein - coupled receptors, which are thought to traverse the cytoplasmic membrane seven times.

In this case, the bacteria - derived molecules are mimicking human ligands that bind to a class of receptors known as GPCRs, for G - protein - coupled receptors.

HIV - 1 Entry Cofactor: Functional cDNA Cloning of a Seven - Transmembrane, G Protein - Coupled Receptor

This protein, designated «fusin,» is a putative G protein - coupled receptor with seven transmembrane segments.

Nobel Prize - winning work back in 1991 showed that, in mammals, each sensory neuron in the main olfactory system expresses one type of G - protein coupled receptor (GPCR), which is specialized to detect a specific type of odor.

Cannabinoid receptors are part of a large class of receptors known as G protein - coupled receptors (GPCR), which account for about 40 percent of all prescription pharmaceuticals on the market, and play key roles in many physiological functions.

Hormones and neurotransmitters may mediate common responses through receptors that couple to the same class of heterotrimeric guanine nucleotide — binding (G) protein.

Heterotrimeric guanine nucleotide — binding protein (G protein)-- coupled receptors constitute the largest family of eukaryotic signal transduction proteins that communicate across the membrane.

Partial activation of the yeast pheromone response pathway by beta - adrenergic receptor agonists was achieved in cells coexpressing h beta - AR and a mammalian G protein (Gs) alpha subunit - demonstrating that these components can couple to each other and to downstream effectors when expressed in yeast.

The dopamine receptors the researchers studied belong to a family called G protein - coupled receptors (GPCRs), and the newly discovered PRMT - 5 mechanism may be active on hundreds of these receptors — creating huge potential for new therapeutics.

G protein — coupled receptor (GPCR)-- dependent activation of protein kinase A (PKA) led to phosphorylation of RCS at Ser55 and increased its binding to CaM.

«The ability to control the functional states of opioid receptors is of particular interest because they belong to the large family of so - called G - protein - coupled transmembrane receptors (GPCRs), which make up a large fraction of the proteins targeted by pharmaceutical agents,» says Matthias Schönberger, first author of the new study.

In the vagus nerve, Strochlic ranked the expression of G - protein - coupled receptors (GPCRs), known for their involvement in sensing and sending messages.

Research led by scientists at the University of Birmingham shows more precisely how G protein - coupled receptors, which are the key target of a large number of drugs, work.

The 2012 Nobel Prize in Chemistry was awarded jointly to Robert J. Lefkowitz and Brian Kobilka for studies of G - protein - coupled receptors, which are the portals by which information about the environment reaches the interior of cells and leads to their responses.

About 30 percent of medications on the market activate G - protein coupled receptors on cell surfaces and trigger chemical signals inside cells to yield their therapeutic effects.

Both CB1 and D2 receptors couple to Gi - o proteins and inhibit adenylyl - cyclase, whereas their costimulation results in Gs protein - dependent activation of adenylyl - cyclase (44, 45).

Plasma Membrane and Nuclear Localization of G Protein — coupled Receptor Kinase 6A.

These events occur when specific extracellular molecules bind to receptor proteins in the plasma membrane known as receptor tyrosine kinases and heterotrimeric G - protein - coupled receptors.

CXCR4 is a G - protein - coupled receptor involved in a number of physiological processes in the hematopoietic and immune systems.

A Single Conserved Leucine Residue on the First Intracellular Loop Regulates ER Export of G Protein - Coupled Receptors.

A conserved motif for the transport of G protein - coupled receptors from the endoplasmic reticulum to the cell surface.

G protein - coupled receptor kinase and β - arrestin - mediated desensitization of the angiotensin II type 1A receptor elucidated by diacylglycerol dynamics.

Visualization and Quantitative Analysis of G Protein - Coupled Receptor - β - Arrestin Interaction in Single Cells and Specific Organs of Living Mice Using Split Luciferase Complementation.

Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body's hard - working G protein - coupled receptors (GPCRs)...

The Groups II and III of glutamate receptor membranes are coupled to the intracellular G - protein subunit, these mediate the inhibition of adenylyl cyclase [40, 41].

They are polymodal ion channels that are subjected to extensive regulation by a diverse set of physical (pH, temperature, mechanical force) and biological signals (lipids, G - protein coupled receptor pathways).

The α - arrestin ARRDC3 mediates ALIX ubiquitination and G protein — coupled receptor lysosomal sorting.