Sentences with phrase «g1 cell cycle»

The researchers said the findings fundamentally change the understanding of G1 cell cycle regulation and the molecular origins of many associated cancers.

Not exact matches

There are as many as 14, but the scientists found that cyclin D adds just a single phosphate at one, and only one, of the 14 locations during the early G1 phase of cell cycle progression, essentially make 14 different versions of the Rb tumor suppressor.

They further show that this diterpine downregulates HMG CoA reductase offering support to the concept that mevalonate deprivation causes cell cycle arrest at the G1 phase leading to apoptotic death of the prostate carcinoma cells.

Researchers at Texas Woman's University have shown that a diterpene geranylgeraniol found in linseed oil, Cedrela toona wood oil, sucupira branca fruit oil and more recently, annatto seed oil, suppressed the viability of human DU145 prostate carcinoma cells via cell cycle arrest at the G1 phase and the initiation of apoptosis.

Paull and Whikehart [7] have also shown that p53 and TAp63 (a p53 family member) are relatively elevated in the normal central human corneal endothelium suggesting that these proteins inhibit cell - cycle promotion from the G1 to S phase.

It is currently suggested that HCECs are held in the G1 phase of the cell cycle and can not pass readily into the S phase prior to cell division [14].

In this new study, licensing refers to origin licensing, the process of helicase loading onto DNA for genome duplication purposes during the G1 phase of the cell cycle.

Moreover; the PI3K / AKT pathway also can contribute to melanoma tumorigenesis through mutations or loss in PTEN and dysregulation in expression of AKT, which positively regulates the G1 / S phase progression in cell cycle, suppresses apoptosis and promotes cellular survival.

The major mechanism of B cell suppression by MSCs is attributed partly to the physical contact between MSCs and B cells and in part to the soluble factors released by MSCs; this leads to the blocking of B cell proliferation in the G0 / G1 phase of the cell cycle with no apoptosis 28, 29, 30.

Cyclin D1 - levels varying throughout cell cycle, hence its expression in G1 phase increases in the cell that respond to enter a new cycle after receiving growth factor stimulation [8].

These results suggest that inhibition of mTOR - raptor complex or silencing mTOR gene expression induced cell cycle arrest at G1 phase in ALK + ALCL cells.

The researchers showed that i - motifs mostly form at a particular point in the cell's «life cycle» — the late G1 phase, when DNA is being actively «read».

Inhibition of mTOR expression or function blocked cell cycle progression from G1 to S phase associated with modulation of the CDK inhibitors p21waf1 and p27kip1.

Two newly synthesized 5 - methyltetrahydrofolate - like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1 / S phase and apoptosis in vitro.

This contradictory behavior explained that Cyclin D1 acts as a negative regulative protein under some conditions rather than a positive regulator in the cell cycle, i.e. the modest increase in Cyclin D1 expression could hasten the G1 phase while the overexpression may lead to block the progression through the S - phase [28, 29].

In the correlation between the Cyclin D1 IOD and the different phases of the cell cycle it was noticed that, there was no any statistically association between Cyclin D1 - IOD and G1 phase % or S phase % in the all of individual groups.

This system is used to obtain the percentage of cells in each phase (G0 / G1, S and G2 / M) of the cell cycle for each sample.

[1,4] Flavopiridol is capable of disrupting progression of cells through the cell cycle at the G1 / S and G2 / M transitions.

Instead, aneuploid NSCs present an extended G1 phase, which leads to cell cycle exit and premature differentiation.

ActD has been shown to have a reversible cytostatic effect and the ability to arrest cells in both the G1 and G2 phase of the cell cycle [17].

This blocks promotion of the cell cycle from the G1 to the S phase.

In the 1990s, researchers were beginning to understand the ways cells regulate transitions into the four phases of the cell cycle: G1, synthesis (S) phase, G2, and mitosis.