Sentences with phrase «gdnf effect in human»

He criticizes textualism (a mode of judicial interpretation) by citing the author's attempt to «show how lawmakers are engaged in the creative work of ensuring that natural law... is given effect in our human living.»

The older I become the more I wonder at the enormous and diverse effects in human history that can be traced to the teachings, the deeds, the death, and the resurrection of that one man.»

First, a little history: In the 16th century Protestant and Catholic positions on justification became polarized and soon escalated to include other doctrines, including the authority of the church; scripture and tradition; good works; merit and indulgences; the mass; and sin and its effects in human life.

«The power of God's love», says John Burnaby, «takes effect in human history in no other way than through the wills and actions of men in whom that love has come to dwell To pray is to open the heart to the entry of love — to ask God in; and where God is truly wanted he will always come.

Any BPA that does find its way into our system is quickly excreted from the body and in the very low doses of BPA we may come into contact with poses no negative health effects in humans» said the Council's CEO, Mr Geoff Parker.

Chocolate contains alkaloids such as theobromine and phenethylamine, which have physiological effects in humans, but the presence of theobromine renders it toxic to some animals, such as dogs and cats.

Scientists are forced either to experiment on whole animals, which is expensive, raises ethical issues and may not predict effects in humans, or to perform tests on microscopic human cells found in tissue cultures, which have been altered to live forever and bear little relation to actual living, breathing people.

Neonicotinoids gained popularity as pesticides in the 1990s in part because they target the central nervous system of crop - destroying insects, but don't have the same effects in humans.

If TNP has similar effects in humans, it may even be able to stimulate bone growth after fractures or prevent bone loss due to aging or disuse.

Finally, O'Neill and colleagues looked for evidence of such an effect in humans.

It is, however, too early to say whether corticosteroids have the same effect in humans.

Furthermore, by adding guanine nucleotides at the end of sgRNA (single guided RNA) that composes CRISPR - Cas9, they have successfully created this highly - developed programmable nuclease, which has no measurable off - target effects in the human genome.

Histamines, though, can have deleterious effects in humans, including rashes when contacted with skin and respiratory problems when inhaled — think of the allergic reactions to certain foods, pollen, mold or other environmental conditions.

In ACS» Journal of the American Chemical Society, they report successful tests on a bacterial enzyme that breaks down nicotine and could potentially dull its effects in humans.

The IBS research team (Center for Genome Engineering) has successfully confirmed that CRISPR - Cas9 has accurate on - target effects in human cells, through joint research with the Seoul National University College of Medicine and ToolGen, Inc..

«With this approach, we found that we can attenuate or prevent the downstream toxic effects in human dopaminergic neurons.»

This is not only because tests on laboratory animals can cause much suffering, but also because the relevance of the data they provide for predicting effects in humans or other animals is severely limited by differences among major species.

For Longo, it all added up: The same growth genes that regulate aging and protect against age - related diseases in yeast, mice, and roundworms might have an identical effect in humans.

On the basis of those results, at least one company is attempting to replicate the effect in humans using blood plasma from healthy young people to treat patients with Alzheimer's disease.

This hope does not appear to be completely unfounded: The scientists have already discovered a Ret / GDNF effect in human cells with a PINK1 defect similar to that observed in the fruit fly.

She hypothesized that they might have similar effects in humans.

The effects in humans may be different — especially for those who smoke or drink habitually.

An expanded family of receptor channels that bind neurotransmitters in worms might help to explain behavioral effects in humans.

They point out that the airborne viruses are «as pathogenic as the parental H5N1 strain», a reference to their effects when placed in ferrets» windpipes, which the researchers» previous work suggests is the best way to assess possible effects in humans.

If more research can demonstrate a similar effect in humans, the authors say, irisin could offer a new therapy for osteoporosis.

«We still don't know what effect this amount could have, but it's plausible that it could have a potential opioid effect in humans.»

Researchers set out to examine whether these chemicals, which are widely used in flexible PVC plastics and personal care products, had a similar effect in humans.

Skyler says that he, too, hopes the preliminary data are right and the effects in humans are indeed straightforward.

The focus is now beginning to shift to looking for direct evidence of BPA effects in humans.

For example, he says, because humans and mice have different metabolic rates, lower doses may have similar beneficial effects in humans.

While many researchers have examined these effects in humans as well as animals, most such studies do not assess long - term effects.

Animal studies have shown some of the adverse effects of PAE on placental development, but few studies have examined these effects in humans.

Sixth, adequate power can be obtained with these methods to detect clinically relevant treatment effects in human trials.

«As we identify which bacteria have a similar effect in humans, it should be possible to develop probiotic supplements that specifically improve efficacy of immunotherapies,» he says.

But he adds that the effect in humans matches the same biological pattern found in other animals, such as rats.

«Our results don't prove the EPR effect in humans, but they are completely consistent with it,» Davis says.

Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background.

«Especially promising is that palovarotene has been tested for toxicity and side effects in humans and has been shown to be well tolerated,» says Yamaguchi.

Digenome - seq: genome - wide profiling of CRISPR - Cas9 off - target effects in human cells.

After analyzing 964 sites cleaved in vitro by different 11 sgRNAs and measuring indel frequencies at hundreds of off - target sites in cells, we propose an off - target scoring system of each target site for minimizing CRISPR - Cas9 off - target effects in the human genome.

Anna M.C.M. Doedée «Interaction of paracetamol with the immune system: immunosuppressive effects in human vaccination model» Promotor: Prof. dr. H. van Loveren Co-promotores: dr. R. Janssen, RIVM Bilthoven February 1, 2018.

«We are encouraged in this regard by the strong similarities we found between klotho's effects in humans and mice in our earlier study.

BPA is an endocrine disruptor, or hormone - altering chemical, that has been linked to numerous adverse health effects in humans.

They could also have side effects in humans that didn't happen in mice.

One of the clearest scientific evidence about the action of CBD on skin inflammation is entitled «Cannabidiol produces sebaceous and anti-inflammatory effects in human sebocytes.»

Now researchers in the U.S. and Canada want to hold the first anti-aging clinical trial to see if they can replicate the same effect in humans using a diabetes drug called metformin.

His later work led to the discovery of free radicals and their damaging effects in the human ability to withstand diseases, bringing forward new investigations on human aging at SIRA.

«After testing the drug in mice, we wanted to check whether JQ1 would have the same effect in humans,» explained co-first author Sarah McMahon, a UCSF graduate student in Haldar's lab.

The study also showed that, in contrast to several cancer drugs that have been documented to cause cardiac toxicity, BRD4 inhibitors may be a class of anti-cancer therapeutics that has protective effects in the human heart.

These studies have indicated that, as in other vertebrates, vasopressin's social effects in humans are sex - specific and differ as a function of social context.